About   Help   FAQ
Mammalian Phenotype Browser
Term Detail
MP term:increased susceptibility to neuronal excitotoxicity
Synonym: decreased resistance to neuronal excitotoxicity
Synonym: increased susceptibility to neurotoxicity-induced cell death
MP id: MP:0008235
Definition: greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-acellular phenotype
                is-aabnormal cell physiology
                        is-aabnormal cell death
                                is-aabnormal apoptosis
                                        is-aabnormal neuron apoptosis
                                                is-aincreased neuron apoptosis
                                                        is-aincreased susceptibility to neuronal excitotoxicity [MP:0008235] (53 genotypes, 53 annotations)
                                                                is-aincreased susceptibility to dopaminergic neuron neurotoxicity


mammalian phenotype
        is-acellular phenotype
                is-aabnormal cell physiology
                        is-aabnormal cell death
                                is-aabnormal apoptosis
                                        is-aincreased apoptosis
                                                is-aincreased neuron apoptosis
                                                        is-aincreased susceptibility to neuronal excitotoxicity [MP:0008235] (53 genotypes, 53 annotations)
                                                                is-aincreased susceptibility to dopaminergic neuron neurotoxicity


mammalian phenotype
        is-acellular phenotype
                is-aabnormal cell physiology
                        is-aabnormal cell death
                                is-aincreased cell death
                                        is-aincreased apoptosis
                                                is-aincreased neuron apoptosis
                                                        is-aincreased susceptibility to neuronal excitotoxicity [MP:0008235] (53 genotypes, 53 annotations)
                                                                is-aincreased susceptibility to dopaminergic neuron neurotoxicity


mammalian phenotype
        is-ahomeostasis/metabolism phenotype
                is-aabnormal physiological response to xenobiotic
                        is-aincreased physiological sensitivity to xenobiotic
                                is-aincreased bronchoconstrictive response
                                is-aincreased incidence of tumors by chemical induction
                                is-aincreased susceptibility to neuronal excitotoxicity [MP:0008235] (53 genotypes, 53 annotations)
                                        is-aincreased susceptibility to dopaminergic neuron neurotoxicity
                                is-aincreased susceptibility to ototoxicity-induced hearing loss


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system physiology
                        is-aabnormal neuron physiology
                                is-aabnormal neuron apoptosis
                                        is-aincreased neuron apoptosis
                                                is-aincreased susceptibility to neuronal excitotoxicity [MP:0008235] (53 genotypes, 53 annotations)
                                                        is-aincreased susceptibility to dopaminergic neuron neurotoxicity

Back to entry page

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory