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Mammalian Phenotype Browser
Term Detail
MP term:decreased germinal center B cell number
Synonym: reduced germinal center B cell number
MP id: MP:0008178
Definition: reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen
Number of paths to term: 22

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal hematopoietic cell number
                                                is-aabnormal leukocyte cell number
                                                        is-aabnormal lymphocyte cell number
                                                                is-aabnormal B cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal hematopoietic cell number
                                                is-aabnormal leukocyte cell number
                                                        is-aabnormal lymphocyte cell number
                                                                is-adecreased lymphocyte cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal hematopoietic cell number
                                                is-aabnormal leukocyte cell number
                                                        is-adecreased leukocyte cell number
                                                                is-adecreased lymphocyte cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal hematopoietic cell number
                                                is-adecreased hematopoietic cell number
                                                        is-adecreased leukocyte cell number
                                                                is-adecreased lymphocyte cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal leukocyte cell number
                                                        is-aabnormal lymphocyte cell number
                                                                is-aabnormal B cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal leukocyte cell number
                                                        is-aabnormal lymphocyte cell number
                                                                is-adecreased lymphocyte cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal leukocyte cell number
                                                        is-adecreased leukocyte cell number
                                                                is-adecreased lymphocyte cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal B cell morphology
                                                                        is-aabnormal B cell number
                                                                                is-adecreased B cell number
                                                                                        is-adecreased mature B cell number
                                                                                                is-aabsent mature B cells +
                                                                                                is-adecreased B-1 B cell number +
                                                                                                is-adecreased B-2 B cell number +
                                                                                                is-adecreased follicular B cell number +
                                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                        is-aabsent germinal center B cells
                                                                                                is-adecreased marginal zone B cell number +
                                                                                                is-adecreased memory B cell number +
                                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal B cell morphology
                                                                        is-aabnormal mature B cell morphology
                                                                                is-aabnormal germinal center B cell morphology
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-aincreased germinal center B cell number


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal B cell morphology
                                                                        is-aabnormal mature B cell morphology
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal lymphocyte cell number
                                                                        is-aabnormal B cell number
                                                                                is-adecreased B cell number
                                                                                        is-adecreased mature B cell number
                                                                                                is-aabsent mature B cells +
                                                                                                is-adecreased B-1 B cell number +
                                                                                                is-adecreased B-2 B cell number +
                                                                                                is-adecreased follicular B cell number +
                                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                        is-aabsent germinal center B cells
                                                                                                is-adecreased marginal zone B cell number +
                                                                                                is-adecreased memory B cell number +
                                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal lymphocyte cell number
                                                                        is-adecreased lymphocyte cell number
                                                                                is-adecreased B cell number
                                                                                        is-adecreased mature B cell number
                                                                                                is-aabsent mature B cells +
                                                                                                is-adecreased B-1 B cell number +
                                                                                                is-adecreased B-2 B cell number +
                                                                                                is-adecreased follicular B cell number +
                                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                        is-aabsent germinal center B cells
                                                                                                is-adecreased marginal zone B cell number +
                                                                                                is-adecreased memory B cell number +
                                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal leukocyte cell number
                                                is-aabnormal lymphocyte cell number
                                                        is-aabnormal B cell number
                                                                is-adecreased B cell number
                                                                        is-adecreased mature B cell number
                                                                                is-aabsent mature B cells +
                                                                                is-adecreased B-1 B cell number +
                                                                                is-adecreased B-2 B cell number +
                                                                                is-adecreased follicular B cell number +
                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                        is-aabsent germinal center B cells
                                                                                is-adecreased marginal zone B cell number +
                                                                                is-adecreased memory B cell number +
                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal leukocyte cell number
                                                is-aabnormal lymphocyte cell number
                                                        is-adecreased lymphocyte cell number
                                                                is-adecreased B cell number
                                                                        is-adecreased mature B cell number
                                                                                is-aabsent mature B cells +
                                                                                is-adecreased B-1 B cell number +
                                                                                is-adecreased B-2 B cell number +
                                                                                is-adecreased follicular B cell number +
                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                        is-aabsent germinal center B cells
                                                                                is-adecreased marginal zone B cell number +
                                                                                is-adecreased memory B cell number +
                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal leukocyte cell number
                                                is-adecreased leukocyte cell number
                                                        is-adecreased lymphocyte cell number
                                                                is-adecreased B cell number
                                                                        is-adecreased mature B cell number
                                                                                is-aabsent mature B cells +
                                                                                is-adecreased B-1 B cell number +
                                                                                is-adecreased B-2 B cell number +
                                                                                is-adecreased follicular B cell number +
                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                        is-aabsent germinal center B cells
                                                                                is-adecreased marginal zone B cell number +
                                                                                is-adecreased memory B cell number +
                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal B cell morphology
                                                                is-aabnormal B cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal B cell morphology
                                                                is-aabnormal mature B cell morphology
                                                                        is-aabnormal germinal center B cell morphology
                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                        is-aabsent germinal center B cells
                                                                                is-aincreased germinal center B cell number


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal B cell morphology
                                                                is-aabnormal mature B cell morphology
                                                                        is-adecreased mature B cell number
                                                                                is-aabsent mature B cells +
                                                                                is-adecreased B-1 B cell number +
                                                                                is-adecreased B-2 B cell number +
                                                                                is-adecreased follicular B cell number +
                                                                                is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                        is-aabsent germinal center B cells
                                                                                is-adecreased marginal zone B cell number +
                                                                                is-adecreased memory B cell number +
                                                                                is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal lymphocyte cell number
                                                                is-aabnormal B cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal lymphocyte cell number
                                                                is-adecreased lymphocyte cell number
                                                                        is-adecreased B cell number
                                                                                is-adecreased mature B cell number
                                                                                        is-aabsent mature B cells +
                                                                                        is-adecreased B-1 B cell number +
                                                                                        is-adecreased B-2 B cell number +
                                                                                        is-adecreased follicular B cell number +
                                                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                                                is-aabsent germinal center B cells
                                                                                        is-adecreased marginal zone B cell number +
                                                                                        is-adecreased memory B cell number +
                                                                                        is-adecreased plasma cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal professional antigen presenting cell morphology
                                        is-aabnormal mature B cell morphology
                                                is-aabnormal germinal center B cell morphology
                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                is-aabsent germinal center B cells
                                                        is-aincreased germinal center B cell number


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal professional antigen presenting cell morphology
                                        is-aabnormal mature B cell morphology
                                                is-adecreased mature B cell number
                                                        is-aabsent mature B cells +
                                                        is-adecreased B-1 B cell number +
                                                        is-adecreased B-2 B cell number +
                                                        is-adecreased follicular B cell number +
                                                        is-adecreased germinal center B cell number [MP:0008178] (51 genotypes, 52 annotations)
                                                                is-aabsent germinal center B cells
                                                        is-adecreased marginal zone B cell number +
                                                        is-adecreased memory B cell number +
                                                        is-adecreased plasma cell number +

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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory