| MP term: | abnormal germinal center B cell morphology |
| MP id: | MP:0008176 |
| Definition: | any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen |
| Number of paths to term: | 4 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal B cell morphologyabnormal mature B cell morphologyabnormal B-1 B cell morphology +abnormal B-2 B cell morphology +abnormal follicular B cell morphology +abnormal germinal center B cell morphology [MP:0008176] (78 genotypes, 84 annotations)decreased germinal center B cell number +increased germinal center B cell numberabnormal marginal zone B cell morphology +abnormal memory B cell morphology +abnormal naive B cell morphology +decreased mature B cell number +increased mature B cell number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal B cell morphologyabnormal mature B cell morphologyabnormal B-1 B cell morphology +abnormal B-2 B cell morphology +abnormal follicular B cell morphology +abnormal germinal center B cell morphology [MP:0008176] (78 genotypes, 84 annotations)decreased germinal center B cell number +increased germinal center B cell numberabnormal marginal zone B cell morphology +abnormal memory B cell morphology +abnormal naive B cell morphology +decreased mature B cell number +increased mature B cell number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal B cell morphologyabnormal mature B cell morphologyabnormal B-1 B cell morphology +abnormal B-2 B cell morphology +abnormal follicular B cell morphology +abnormal germinal center B cell morphology [MP:0008176] (78 genotypes, 84 annotations)decreased germinal center B cell number +increased germinal center B cell numberabnormal marginal zone B cell morphology +abnormal memory B cell morphology +abnormal naive B cell morphology +decreased mature B cell number +increased mature B cell number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal professional antigen presenting cell morphologyabnormal mature B cell morphologyabnormal B-1 B cell morphology +abnormal B-2 B cell morphology +abnormal follicular B cell morphology +abnormal germinal center B cell morphology [MP:0008176] (78 genotypes, 84 annotations)decreased germinal center B cell number +increased germinal center B cell numberabnormal marginal zone B cell morphology +abnormal memory B cell morphology +abnormal naive B cell morphology +decreased mature B cell number +increased mature B cell number +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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