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Mammalian Phenotype Browser
Term Detail
MP term:abnormal Langerhans cell physiology
Synonym: abnormal Langerhans cell function
MP id: MP:0005362
Definition: atypical or failure of normal function of the stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal dendritic cell physiology
                                                is-aabnormal dendritic cell antigen presentation +
                                                is-aabnormal dendritic cell chemotaxis
                                                is-aabnormal Langerhans cell physiology [MP:0005362] (18 genotypes, 18 annotations)
                                                        is-aabnormal Langerhans cell antigen presentation
                                                is-aabnormal plasmacytoid dendritic cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal dendritic cell physiology
                                                is-aabnormal dendritic cell antigen presentation +
                                                is-aabnormal dendritic cell chemotaxis
                                                is-aabnormal Langerhans cell physiology [MP:0005362] (18 genotypes, 18 annotations)
                                                        is-aabnormal Langerhans cell antigen presentation
                                                is-aabnormal plasmacytoid dendritic cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal dendritic cell physiology
                                                is-aabnormal dendritic cell antigen presentation +
                                                is-aabnormal dendritic cell chemotaxis
                                                is-aabnormal Langerhans cell physiology [MP:0005362] (18 genotypes, 18 annotations)
                                                        is-aabnormal Langerhans cell antigen presentation
                                                is-aabnormal plasmacytoid dendritic cell physiology

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory