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Mammalian Phenotype Browser
Term Detail
MP term:abnormal Harderian gland morphology
Synonym: Harderian gland abnormalities
Synonym: Harderian gland dysplasia
MP id: MP:0005248
Definition: any structural anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents) of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-aendocrine/exocrine gland phenotype
                is-aabnormal gland morphology
                        is-aabnormal exocrine gland morphology
                                is-aabnormal merocrine gland morphology
                                        is-aabnormal eccrine sweat gland morphology +
                                        is-aabnormal Harderian gland morphology [MP:0005248] (29 genotypes, 30 annotations)
                                                is-aabnormal Harderian gland development
                                                is-aabnormal Harderian gland pigmentation
                                                is-aabnormal Harderian gland size +
                                                is-aabsent Harderian gland
                                        is-aabnormal salivary gland morphology +

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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory