| MP term: | decreased regulatory T cell number |
| Synonym: | decreased suppressor T cell number |
| Synonym: | decreased Treg cell number |
| Synonym: | reduced regulatory T cell number |
| Synonym: | reduced Treg cell number |
| MP id: | MP:0004974 |
| Definition: | reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity |
| Number of paths to term: | 35 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal hematopoietic cell numberabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal hematopoietic cell numberabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal hematopoietic cell numberabnormal leukocyte cell numberabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal hematopoietic cell numberabnormal leukocyte cell numberdecreased leukocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal hematopoietic cell numberdecreased hematopoietic cell numberdecreased leukocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal leukocyte cell numberdecreased leukocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal regulatory T cell morphologyabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal leukocyte cell numberdecreased leukocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal regulatory T cell morphologyabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal leukocyte cell numberabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal leukocyte cell numberdecreased leukocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphocyte cell numberdecreased lymphocyte cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal regulatory T cell morphologyabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell numberabnormal regulatory T cell numberdecreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsincreased regulatory T cell numberimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell numberdecreased T cell numberabsent T cells +decreased activated T cell numberdecreased double-negative T cell number +decreased double-positive T cell numberdecreased gamma-delta T cell number +decreased memory T cell number +decreased NK T cell number +decreased regulatory T cell number [MP:0004974] (64 genotypes, 64 annotations)absent regulatory T cellsdecreased single-positive T cell number +decreased thymocyte number +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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