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Mammalian Phenotype Browser
Term Detail
MP term:abnormal regulatory T cell physiology
MP id: MP:0004946
Definition: any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal T cell physiology
                                                        is-aabnormal CD4-positive, alpha-beta T cell physiology +
                                                        is-aabnormal CD8-positive, alpha-beta T cell physiology +
                                                        is-aabnormal memory T cell physiology +
                                                        is-aabnormal NK T cell physiology
                                                        is-aabnormal regulatory T cell physiology [MP:0004946] (48 genotypes, 49 annotations)
                                                                is-adecreased regulatory T cell apoptosis
                                                                is-aincreased regulatory T cell apoptosis
                                                        is-aabnormal T cell activation +
                                                        is-aabnormal T cell apoptosis +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal T cell physiology
                                                        is-aabnormal CD4-positive, alpha-beta T cell physiology +
                                                        is-aabnormal CD8-positive, alpha-beta T cell physiology +
                                                        is-aabnormal memory T cell physiology +
                                                        is-aabnormal NK T cell physiology
                                                        is-aabnormal regulatory T cell physiology [MP:0004946] (48 genotypes, 49 annotations)
                                                                is-adecreased regulatory T cell apoptosis
                                                                is-aincreased regulatory T cell apoptosis
                                                        is-aabnormal T cell activation +
                                                        is-aabnormal T cell apoptosis +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal T cell physiology
                                                        is-aabnormal CD4-positive, alpha-beta T cell physiology +
                                                        is-aabnormal CD8-positive, alpha-beta T cell physiology +
                                                        is-aabnormal memory T cell physiology +
                                                        is-aabnormal NK T cell physiology
                                                        is-aabnormal regulatory T cell physiology [MP:0004946] (48 genotypes, 49 annotations)
                                                                is-adecreased regulatory T cell apoptosis
                                                                is-aincreased regulatory T cell apoptosis
                                                        is-aabnormal T cell activation +
                                                        is-aabnormal T cell apoptosis +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal T cell physiology
                                                        is-aabnormal CD4-positive, alpha-beta T cell physiology +
                                                        is-aabnormal CD8-positive, alpha-beta T cell physiology +
                                                        is-aabnormal memory T cell physiology +
                                                        is-aabnormal NK T cell physiology
                                                        is-aabnormal regulatory T cell physiology [MP:0004946] (48 genotypes, 49 annotations)
                                                                is-adecreased regulatory T cell apoptosis
                                                                is-aincreased regulatory T cell apoptosis
                                                        is-aabnormal T cell activation +
                                                        is-aabnormal T cell apoptosis +

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory