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Mammalian Phenotype Browser
Term Detail
MP term:abnormal cochlear hair bundle tip links morphology
MP id: MP:0004578
Definition: any structural anomaly in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal cochlea morphology
                                        is-aabnormal cochlear sensory epithelium morphology
                                                is-aabnormal cochlear hair cell morphology
                                                        is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                is-aabnormal cochlear hair cell inter-stereocilial links morphology
                                                                        is-aabnormal cochlear hair bundle ankle links morphology +
                                                                        is-aabnormal cochlear hair bundle horizontal top connectors morphology
                                                                        is-aabnormal cochlear hair bundle tip links morphology [MP:0004578] (7 genotypes, 7 annotations)
                                                                        is-aabnormal cochlear hair bundle transient lateral links morphology


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal cochlea morphology
                                        is-aabnormal scala media morphology
                                                is-aabnormal organ of Corti morphology
                                                        is-aabnormal cochlear hair cell morphology
                                                                is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                        is-aabnormal cochlear hair cell inter-stereocilial links morphology
                                                                                is-aabnormal cochlear hair bundle ankle links morphology +
                                                                                is-aabnormal cochlear hair bundle horizontal top connectors morphology
                                                                                is-aabnormal cochlear hair bundle tip links morphology [MP:0004578] (7 genotypes, 7 annotations)
                                                                                is-aabnormal cochlear hair bundle transient lateral links morphology


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal hair cell morphology
                                        is-aabnormal cochlear hair cell morphology
                                                is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                        is-aabnormal cochlear hair cell inter-stereocilial links morphology
                                                                is-aabnormal cochlear hair bundle ankle links morphology +
                                                                is-aabnormal cochlear hair bundle horizontal top connectors morphology
                                                                is-aabnormal cochlear hair bundle tip links morphology [MP:0004578] (7 genotypes, 7 annotations)
                                                                is-aabnormal cochlear hair bundle transient lateral links morphology


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal membranous labyrinth morphology
                                        is-aabnormal cochlear labyrinth morphology
                                                is-aabnormal scala media morphology
                                                        is-aabnormal organ of Corti morphology
                                                                is-aabnormal cochlear hair cell morphology
                                                                        is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                                is-aabnormal cochlear hair cell inter-stereocilial links morphology
                                                                                        is-aabnormal cochlear hair bundle ankle links morphology +
                                                                                        is-aabnormal cochlear hair bundle horizontal top connectors morphology
                                                                                        is-aabnormal cochlear hair bundle tip links morphology [MP:0004578] (7 genotypes, 7 annotations)
                                                                                        is-aabnormal cochlear hair bundle transient lateral links morphology


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal neuron morphology
                                is-aabnormal sensory neuron morphology
                                        is-aabnormal mechanoreceptor morphology
                                                is-aabnormal hair cell morphology
                                                        is-aabnormal cochlear hair cell morphology
                                                                is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                        is-aabnormal cochlear hair cell inter-stereocilial links morphology
                                                                                is-aabnormal cochlear hair bundle ankle links morphology +
                                                                                is-aabnormal cochlear hair bundle horizontal top connectors morphology
                                                                                is-aabnormal cochlear hair bundle tip links morphology [MP:0004578] (7 genotypes, 7 annotations)
                                                                                is-aabnormal cochlear hair bundle transient lateral links morphology


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal somatic nervous system morphology
                                is-aabnormal somatic sensory system morphology
                                        is-aabnormal sensory neuron morphology
                                                is-aabnormal mechanoreceptor morphology
                                                        is-aabnormal hair cell morphology
                                                                is-aabnormal cochlear hair cell morphology
                                                                        is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                                is-aabnormal cochlear hair cell inter-stereocilial links morphology
                                                                                        is-aabnormal cochlear hair bundle ankle links morphology +
                                                                                        is-aabnormal cochlear hair bundle horizontal top connectors morphology
                                                                                        is-aabnormal cochlear hair bundle tip links morphology [MP:0004578] (7 genotypes, 7 annotations)
                                                                                        is-aabnormal cochlear hair bundle transient lateral links morphology

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory