About   Help   FAQ
Mammalian Phenotype Browser
Term Detail
MP term:abnormal intestinal goblet cell morphology
Synonym: abnormal intestinal goblet cells
MP id: MP:0003449
Definition: any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; the goblet cell is a highly polarized unicellular exocrine gland with the nucleus and other organelles concentrated at the base of the cell; the remainder of the cell's cytoplasm is occupied by membrane-bound secretory granules containing mucin; the goblet shape is due to the mucus laden granules in the apical part expanding, causing that part of the cell to balloon; the apical plasma membrane projects microvilli to give an increased surface area for secretion
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-adigestive/alimentary phenotype
                is-aabnormal digestive system morphology
                        is-aabnormal intestine morphology
                                is-aabnormal intestinal epithelium morphology
                                        is-aabnormal intestinal mucosa morphology
                                                is-aabnormal Brunner's gland morphology +
                                                is-aabnormal crypts of Lieberkuhn morphology +
                                                is-aabnormal intestinal enteroendocrine cell morphology
                                                is-aabnormal intestinal goblet cell morphology [MP:0003449] (110 genotypes, 114 annotations)
                                                        is-aabnormal large intestine goblet cell morphology +
                                                        is-aabnormal small intestine goblet cell morphology +
                                                is-aabnormal intestinal mucosa thickness +
                                                is-aintestinal ulcer

Back to entry page

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.08
The Jackson Laboratory