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Mammalian Phenotype Browser
Term Detail
MP term:neurofibrillary tangles
Synonym: neuritic plaques
Synonym: senile plaques
MP id: MP:0003214
Definition: dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease and other tauopathies
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal brain morphology
                                is-aabnormal brain cholesterol level +
                                is-aabnormal brain copper level +
                                is-aabnormal brain development +
                                is-aabnormal brain interneuron morphology
                                is-aabnormal brain iron level +
                                is-aabnormal brain size +
                                is-aabnormal brain vasculature morphology +
                                is-aabnormal brain ventricular system morphology +
                                is-aabnormal brain white matter morphology +
                                is-aabnormal brainstem morphology +
                                is-aabnormal circumventricular organ morphology +
                                is-aabnormal forebrain morphology +
                                is-aabnormal hindbrain morphology +
                                is-aabnormal midbrain morphology +
                                is-aabnormal postnatal subventricular zone morphology +
                                is-abasal brain tissue herniation
                                is-abrain atrophy +
                                is-abrain vacuoles
                                is-adecreased brain plasmalogen level
                                is-adecreased sulfoglycosphingolipid level +
                                is-aincreased brain plasmalogen level
                                is-aincreased brain sulfoglycosphingolipid level
                                is-aneurofibrillary tangles [MP:0003214] (33 genotypes, 33 annotations)
                                is-atau protein deposits

mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-anervous system inclusion bodies
                                is-aalpha-synuclein inclusion body
                                is-aamyloid beta deposits
                                is-aargyrophilic inclusion bodies
                                is-acerebral amyloid angiopathy
                                is-aHirano bodies
                                is-aLafora bodies
                                is-aLewy bodies
                                is-aneurofibrillary tangles [MP:0003214] (33 genotypes, 33 annotations)
                                is-aRosenthal fibers
                                is-atau protein deposits

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MGI 6.08
The Jackson Laboratory