| MP term: | abnormal double-positive T cell morphology |
| Synonym: | abnormal double positive T cell morphology |
| Synonym: | CD4+CD8+ T cell abnormalities |
| Synonym: | double-positive T cell abnormalities |
| Synonym: | double-positive T-cell abnormalities |
| MP id: | MP:0002408 |
| Definition: | any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8 |
| Number of paths to term: | 12 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
cellular phenotypeabnormal cell physiologyabnormal cell differentiationabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukopoiesisabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukopoiesisabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal bone marrow cell morphology/developmentabnormal myeloblast morphology/developmentabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal T cell morphologyabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukopoiesisabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukopoiesisabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal T cell differentiationabnormal CD4-positive T cell differentiation +abnormal CD8-positive T cell differentiationabnormal double-negative T cell morphology +abnormal double-positive T cell morphology [MP:0002408] (416 genotypes, 427 annotations)decreased double-positive T cell numberincreased double-positive T cell numberabnormal gamma-delta T cell differentiationabnormal T cell activation +abnormal T cell receptor V(D)J recombination +abnormal T cell selection +abnormal T-helper 17 cell differentiationarrested T cell differentiationMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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