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Mammalian Phenotype Browser
Term Detail
MP term:abnormal double-positive T cell morphology
Synonym: abnormal double positive T cell morphology
Synonym: CD4+CD8+ T cell abnormalities
Synonym: double-positive T cell abnormalities
Synonym: double-positive T-cell abnormalities
MP id: MP:0002408
Definition: any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hemopoiesis
                                        is-aabnormal definitive hematopoiesis
                                                is-aabnormal leukopoiesis
                                                        is-aabnormal lymphopoiesis
                                                                is-aabnormal T cell differentiation
                                                                        is-aabnormal CD4-positive T cell differentiation +
                                                                        is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                                        is-aabnormal double-negative T cell morphology +
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal gamma-delta T cell differentiation
                                                                        is-aabnormal T cell receptor V(D)J recombination +
                                                                        is-aabnormal T cell selection +
                                                                        is-aabnormal T-helper 17 cell differentiation
                                                                        is-aarrested T cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal hematopoietic cell morphology
                                is-aabnormal blood cell morphology
                                        is-aabnormal hemopoiesis
                                                is-aabnormal definitive hematopoiesis
                                                        is-aabnormal leukopoiesis
                                                                is-aabnormal lymphopoiesis
                                                                        is-aabnormal T cell differentiation
                                                                                is-aabnormal CD4-positive T cell differentiation +
                                                                                is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                                                is-aabnormal double-negative T cell morphology +
                                                                                is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                        is-adecreased double-positive T cell number
                                                                                        is-aincreased double-positive T cell number
                                                                                is-aabnormal gamma-delta T cell differentiation
                                                                                is-aabnormal T cell receptor V(D)J recombination +
                                                                                is-aabnormal T cell selection +
                                                                                is-aabnormal T-helper 17 cell differentiation
                                                                                is-aarrested T cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal hematopoietic cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal lymphopoiesis
                                                                is-aabnormal T cell differentiation
                                                                        is-aabnormal CD4-positive T cell differentiation +
                                                                        is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                                        is-aabnormal double-negative T cell morphology +
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal gamma-delta T cell differentiation
                                                                        is-aabnormal T cell receptor V(D)J recombination +
                                                                        is-aabnormal T cell selection +
                                                                        is-aabnormal T-helper 17 cell differentiation
                                                                        is-aarrested T cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal hematopoietic cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal T cell morphology
                                                                is-aabnormal alpha-beta T cell morphology
                                                                        is-aabnormal alpha-beta intraepithelial T cell morphology +
                                                                        is-aabnormal alpha-beta T cell number +
                                                                        is-aabnormal CD4-positive, alpha beta T cell morphology +
                                                                        is-aabnormal CD4-positive, alpha-beta intraepithelial T cell morphology
                                                                        is-aabnormal CD4-positive, alpha-beta memory T cell morphology +
                                                                        is-aabnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology +
                                                                        is-aabnormal CD8 positive, alpha-beta intraepithelial T cell morphology
                                                                        is-aabnormal CD8-positive, alpha beta T cell morphology +
                                                                        is-aabnormal CD8-positive, alpha-beta cytotoxic T cell morphology
                                                                        is-aabnormal CD8-positive, alpha-beta memory T cell morphology +
                                                                        is-aabnormal CD8-positive, alpha-beta regulatory T cell morphology
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal NK T cell morphology +


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal hematopoietic cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal T cell morphology
                                                                is-aabnormal T cell differentiation
                                                                        is-aabnormal CD4-positive T cell differentiation +
                                                                        is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                                        is-aabnormal double-negative T cell morphology +
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal gamma-delta T cell differentiation
                                                                        is-aabnormal T cell receptor V(D)J recombination +
                                                                        is-aabnormal T cell selection +
                                                                        is-aabnormal T-helper 17 cell differentiation
                                                                        is-aarrested T cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal lymphopoiesis
                                                                is-aabnormal T cell differentiation
                                                                        is-aabnormal CD4-positive T cell differentiation +
                                                                        is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                                        is-aabnormal double-negative T cell morphology +
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal gamma-delta T cell differentiation
                                                                        is-aabnormal T cell receptor V(D)J recombination +
                                                                        is-aabnormal T cell selection +
                                                                        is-aabnormal T-helper 17 cell differentiation
                                                                        is-aarrested T cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal T cell morphology
                                                                is-aabnormal alpha-beta T cell morphology
                                                                        is-aabnormal alpha-beta intraepithelial T cell morphology +
                                                                        is-aabnormal alpha-beta T cell number +
                                                                        is-aabnormal CD4-positive, alpha beta T cell morphology +
                                                                        is-aabnormal CD4-positive, alpha-beta intraepithelial T cell morphology
                                                                        is-aabnormal CD4-positive, alpha-beta memory T cell morphology +
                                                                        is-aabnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology +
                                                                        is-aabnormal CD8 positive, alpha-beta intraepithelial T cell morphology
                                                                        is-aabnormal CD8-positive, alpha beta T cell morphology +
                                                                        is-aabnormal CD8-positive, alpha-beta cytotoxic T cell morphology
                                                                        is-aabnormal CD8-positive, alpha-beta memory T cell morphology +
                                                                        is-aabnormal CD8-positive, alpha-beta regulatory T cell morphology
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal NK T cell morphology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal T cell morphology
                                                                is-aabnormal T cell differentiation
                                                                        is-aabnormal CD4-positive T cell differentiation +
                                                                        is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                                        is-aabnormal double-negative T cell morphology +
                                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                                is-adecreased double-positive T cell number
                                                                                is-aincreased double-positive T cell number
                                                                        is-aabnormal gamma-delta T cell differentiation
                                                                        is-aabnormal T cell receptor V(D)J recombination +
                                                                        is-aabnormal T cell selection +
                                                                        is-aabnormal T-helper 17 cell differentiation
                                                                        is-aarrested T cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukopoiesis
                                        is-aabnormal lymphopoiesis
                                                is-aabnormal T cell differentiation
                                                        is-aabnormal CD4-positive T cell differentiation +
                                                        is-aabnormal CD8-positive, alpha-beta T cell differentiation
                                                        is-aabnormal double-negative T cell morphology +
                                                        is-aabnormal double-positive T cell morphology [MP:0002408] (438 genotypes, 451 annotations)
                                                                is-adecreased double-positive T cell number
                                                                is-aincreased double-positive T cell number
                                                        is-aabnormal gamma-delta T cell differentiation
                                                        is-aabnormal T cell receptor V(D)J recombination +
                                                        is-aabnormal T cell selection +
                                                        is-aabnormal T-helper 17 cell differentiation
                                                        is-aarrested T cell differentiation

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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory