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Mammalian Phenotype Browser
Term Detail
MP term:abnormal roof plate morphology
Synonym: roof plate abnormalities
Synonym: roof plate dysplasia
MP id: MP:0000923
Definition: any structural anomaly of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-aembryogenesis phenotype
                is-aabnormal embryogenesis/ development
                        is-aabnormal embryonic tissue morphology
                                is-aabnormal neural tube morphology/development
                                        is-aabnormal embryonic neuroepithelium morphology +
                                        is-aabnormal floor plate morphology +
                                        is-aabnormal lamina terminalis morphology +
                                        is-aabnormal neural crest morphology +
                                        is-aabnormal neural tube closure +
                                        is-aabnormal neural tube mantle layer morphology +
                                        is-aabnormal neural tube marginal layer morphology
                                        is-aabnormal neural tube ventricular layer morphology
                                        is-aabnormal neuromere morphology +
                                        is-aabnormal neuropore morphology +
                                        is-aabnormal roof plate morphology [MP:0000923] (15 genotypes, 15 annotations)
                                                is-aabsent roof plate
                                        is-acaudal rachischisis
                                        is-acraniorachischisis
                                        is-akinked neural tube
                                        is-aneural tube degeneration
                                        is-awavy neural tube


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal nervous system development
                                is-aabnormal neural tube morphology/development
                                        is-aabnormal embryonic neuroepithelium morphology +
                                        is-aabnormal floor plate morphology +
                                        is-aabnormal lamina terminalis morphology +
                                        is-aabnormal neural crest morphology +
                                        is-aabnormal neural tube closure +
                                        is-aabnormal neural tube mantle layer morphology +
                                        is-aabnormal neural tube marginal layer morphology
                                        is-aabnormal neural tube ventricular layer morphology
                                        is-aabnormal neuromere morphology +
                                        is-aabnormal neuropore morphology +
                                        is-aabnormal roof plate morphology [MP:0000923] (15 genotypes, 15 annotations)
                                                is-aabsent roof plate
                                        is-acaudal rachischisis
                                        is-acraniorachischisis
                                        is-akinked neural tube
                                        is-aneural tube degeneration
                                        is-awavy neural tube

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory