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Gene Ontology Browser
Term Detail
GO term:ruffle assembly
Synonym: membrane ruffle formation
Synonym: membrane ruffling
GO id:GO:0097178
Definition:The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.
Number of paths to term: 8

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular component organization or biogenesis
                        is-acellular component biogenesis
                                part-ofcellular component assembly
                                        is-acell projection assembly
                                                is-aaxoneme assembly +
                                                is-abacterial-type flagellum assembly +
                                                is-ableb assembly
                                                is-acilium assembly +
                                                is-acytoneme assembly
                                                is-adendritic cell dendrite assembly +
                                                is-afilopodium assembly +
                                                is-alamellipodium assembly +
                                                is-amating projection assembly +
                                                is-amicrospike assembly
                                                is-amicrovillus assembly +
                                                is-apial surface process extension
                                                is-apilus assembly +
                                                is-apseudopodium assembly +
                                                regulatesregulation of cell projection assembly +
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +
                                                is-asubstrate-dependent cell migration, cell extension
                                                is-auropod assembly


Gene_Ontology
        is-abiological_process
                is-acellular component organization or biogenesis
                        is-acellular component organization
                                is-acell projection organization
                                        is-acell projection assembly
                                                is-aaxoneme assembly +
                                                is-abacterial-type flagellum assembly +
                                                is-ableb assembly
                                                is-acilium assembly +
                                                is-acytoneme assembly
                                                is-adendritic cell dendrite assembly +
                                                is-afilopodium assembly +
                                                is-alamellipodium assembly +
                                                is-amating projection assembly +
                                                is-amicrospike assembly
                                                is-amicrovillus assembly +
                                                is-apial surface process extension
                                                is-apilus assembly +
                                                is-apseudopodium assembly +
                                                regulatesregulation of cell projection assembly +
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +
                                                is-asubstrate-dependent cell migration, cell extension
                                                is-auropod assembly


Gene_Ontology
        is-abiological_process
                is-acellular component organization or biogenesis
                        is-acellular component organization
                                is-acell projection organization
                                        is-aruffle organization
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +


Gene_Ontology
        is-abiological_process
                is-acellular component organization or biogenesis
                        is-acellular component organization
                                is-acellular component assembly
                                        is-acell projection assembly
                                                is-aaxoneme assembly +
                                                is-abacterial-type flagellum assembly +
                                                is-ableb assembly
                                                is-acilium assembly +
                                                is-acytoneme assembly
                                                is-adendritic cell dendrite assembly +
                                                is-afilopodium assembly +
                                                is-alamellipodium assembly +
                                                is-amating projection assembly +
                                                is-amicrospike assembly
                                                is-amicrovillus assembly +
                                                is-apial surface process extension
                                                is-apilus assembly +
                                                is-apseudopodium assembly +
                                                regulatesregulation of cell projection assembly +
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +
                                                is-asubstrate-dependent cell migration, cell extension
                                                is-auropod assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell projection organization
                                        is-acell projection assembly
                                                is-aaxoneme assembly +
                                                is-abacterial-type flagellum assembly +
                                                is-ableb assembly
                                                is-acilium assembly +
                                                is-acytoneme assembly
                                                is-adendritic cell dendrite assembly +
                                                is-afilopodium assembly +
                                                is-alamellipodium assembly +
                                                is-amating projection assembly +
                                                is-amicrospike assembly
                                                is-amicrovillus assembly +
                                                is-apial surface process extension
                                                is-apilus assembly +
                                                is-apseudopodium assembly +
                                                regulatesregulation of cell projection assembly +
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +
                                                is-asubstrate-dependent cell migration, cell extension
                                                is-auropod assembly


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell projection organization
                                        is-aruffle organization
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell projection organization
                                        is-acell projection assembly
                                                is-aaxoneme assembly +
                                                is-abacterial-type flagellum assembly +
                                                is-ableb assembly
                                                is-acilium assembly +
                                                is-acytoneme assembly
                                                is-adendritic cell dendrite assembly +
                                                is-afilopodium assembly +
                                                is-alamellipodium assembly +
                                                is-amating projection assembly +
                                                is-amicrospike assembly
                                                is-amicrovillus assembly +
                                                is-apial surface process extension
                                                is-apilus assembly +
                                                is-apseudopodium assembly +
                                                regulatesregulation of cell projection assembly +
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +
                                                is-asubstrate-dependent cell migration, cell extension
                                                is-auropod assembly


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell projection organization
                                        is-aruffle organization
                                                is-aruffle assembly [GO:0097178] (22 genes, 24 annotations)
                                                        negatively-regulatesnegative regulation of ruffle assembly
                                                        positively-regulatespositive regulation of ruffle assembly
                                                        regulatesregulation of ruffle assembly +


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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory