| GO term: | ruffle assembly |
| Synonym: | membrane ruffle formation |
| Synonym: | membrane ruffling |
| GO id: | GO:0097178 |
| Definition: | The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. |
| Number of paths to term: | 8 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular component organization or biogenesiscellular component biogenesiscellular component assemblycell projection assemblyaxoneme assembly +bacterial-type flagellum assemblybleb assemblycilium assembly +cytoneme assemblydendritic cell dendrite assembly +filopodium assembly +flagellum assembly +lamellipodium assembly +mating projection assembly +microspike assemblymicrovillus assembly +pial surface process extensionpilus assembly +pseudopodium assembly +regulation of cell projection assembly +ruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +substrate-dependent cell migration, cell extensionuropod assemblybiological_processcellular component organization or biogenesiscellular component organizationcell projection organizationcell projection assemblyaxoneme assembly +bacterial-type flagellum assemblybleb assemblycilium assembly +cytoneme assemblydendritic cell dendrite assembly +filopodium assembly +flagellum assembly +lamellipodium assembly +mating projection assembly +microspike assemblymicrovillus assembly +pial surface process extensionpilus assembly +pseudopodium assembly +regulation of cell projection assembly +ruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +substrate-dependent cell migration, cell extensionuropod assemblybiological_processcellular component organization or biogenesiscellular component organizationcell projection organizationruffle organizationruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +biological_processcellular component organization or biogenesiscellular component organizationcellular component assemblycell projection assemblyaxoneme assembly +bacterial-type flagellum assemblybleb assemblycilium assembly +cytoneme assemblydendritic cell dendrite assembly +filopodium assembly +flagellum assembly +lamellipodium assembly +mating projection assembly +microspike assemblymicrovillus assembly +pial surface process extensionpilus assembly +pseudopodium assembly +regulation of cell projection assembly +ruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +substrate-dependent cell migration, cell extensionuropod assemblybiological_processcellular processsingle-organism cellular processcell projection organizationcell projection assemblyaxoneme assembly +bacterial-type flagellum assemblybleb assemblycilium assembly +cytoneme assemblydendritic cell dendrite assembly +filopodium assembly +flagellum assembly +lamellipodium assembly +mating projection assembly +microspike assemblymicrovillus assembly +pial surface process extensionpilus assembly +pseudopodium assembly +regulation of cell projection assembly +ruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +substrate-dependent cell migration, cell extensionuropod assemblybiological_processcellular processsingle-organism cellular processcell projection organizationruffle organizationruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +biological_processsingle-organism processsingle-organism cellular processcell projection organizationcell projection assemblyaxoneme assembly +bacterial-type flagellum assemblybleb assemblycilium assembly +cytoneme assemblydendritic cell dendrite assembly +filopodium assembly +flagellum assembly +lamellipodium assembly +mating projection assembly +microspike assemblymicrovillus assembly +pial surface process extensionpilus assembly +pseudopodium assembly +regulation of cell projection assembly +ruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +substrate-dependent cell migration, cell extensionuropod assemblybiological_processsingle-organism processsingle-organism cellular processcell projection organizationruffle organizationruffle assembly [GO:0097178] (12 genes, 13 annotations)negative regulation of ruffle assemblypositive regulation of ruffle assemblyregulation of ruffle assembly +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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