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Gene Ontology Browser
Term Detail
GO term:chromosome separation
Synonym: chromatid release
Synonym: rDNA separation
GO id:GO:0051304
Alternate id: GO:0034500
Definition:The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acell cycle process
                                is-aactin filament reorganization involved in cell cycle
                                is-aactomyosin contractile ring assembly actin filament organization +
                                is-aattachment of spindle microtubules to kinetochore +
                                is-acell cycle arrest +
                                is-acell cycle checkpoint +
                                is-acell cycle DNA replication +
                                is-acell cycle DNA replication DNA ligation +
                                is-acell cycle DNA replication DNA unwinding +
                                is-acell cycle DNA replication initiation +
                                is-acell cycle DNA replication maintenance of fidelity +
                                is-acell cycle DNA replication termination +
                                is-acell cycle phase transition +
                                is-acell cycle switching +
                                is-acentriole elongation +
                                is-acentriole replication +
                                is-acentromere separation +
                                is-acentrosome cycle +
                                is-acentrosome duplication +
                                is-acentrosome separation +
                                is-achromosome attachment to the nuclear envelope +
                                is-achromosome movement towards spindle pole +
                                is-achromosome separation [GO:0051304] (65 genes, 84 annotations)
                                        part-ofcentromere separation +
                                        is-ameiotic chromosome separation +
                                        is-amitotic sister chromatid separation +
                                is-acytokinesis +
                                is-acytokinetic process +
                                is-adetection of DNA damage stimulus involved in DNA damage checkpoint +
                                is-adetection of stimulus involved in DNA replication checkpoint +
                                is-aDNA replication preinitiation complex assembly +
                                is-aDNA strand elongation involved in cell cycle DNA replication +
                                is-aestablishment of sister chromatid cohesion +
                                is-aG0 to G1 transition +
                                is-aG1 to G0 transition +
                                is-amaintenance of protein location to spindle pole body
                                is-amaintenance of sister chromatid cohesion +
                                is-ameiotic cell cycle process +
                                is-amicrotubule anchoring at spindle pole body +
                                is-amitotic cell cycle process +
                                is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                negatively-regulatesnegative regulation of cell cycle process +
                                is-anuclear chromosome segregation +
                                positively-regulatespositive regulation of cell cycle process +
                                is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                is-are-entry into mitotic cell cycle +
                                regulatesregulation of cell cycle process +
                                is-aregulation of syncytial blastoderm mitotic cell cycle +
                                is-asignal transduction involved in DNA damage checkpoint +
                                is-asister chromatid cohesion +
                                is-aspindle elongation +
                                is-aspindle localization +
                                is-aspindle midzone assembly +
                                is-aspindle organization +
                                is-aspindle pole body organization +
                                is-aspindle pole body separation +
                                is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                is-atelomere maintenance via semi-conservative replication +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-aactin filament reorganization involved in cell cycle
                                                is-aactomyosin contractile ring assembly actin filament organization +
                                                is-aattachment of spindle microtubules to kinetochore +
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint +
                                                is-acell cycle DNA replication +
                                                is-acell cycle DNA replication DNA ligation +
                                                is-acell cycle DNA replication DNA unwinding +
                                                is-acell cycle DNA replication initiation +
                                                is-acell cycle DNA replication maintenance of fidelity +
                                                is-acell cycle DNA replication termination +
                                                is-acell cycle phase transition +
                                                is-acell cycle switching +
                                                is-acentriole elongation +
                                                is-acentriole replication +
                                                is-acentromere separation +
                                                is-acentrosome cycle +
                                                is-acentrosome duplication +
                                                is-acentrosome separation +
                                                is-achromosome attachment to the nuclear envelope +
                                                is-achromosome movement towards spindle pole +
                                                is-achromosome separation [GO:0051304] (65 genes, 84 annotations)
                                                        part-ofcentromere separation +
                                                        is-ameiotic chromosome separation +
                                                        is-amitotic sister chromatid separation +
                                                is-acytokinesis +
                                                is-acytokinetic process +
                                                is-adetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                is-adetection of stimulus involved in DNA replication checkpoint +
                                                is-aDNA replication preinitiation complex assembly +
                                                is-aDNA strand elongation involved in cell cycle DNA replication +
                                                is-aestablishment of sister chromatid cohesion +
                                                is-aG0 to G1 transition +
                                                is-aG1 to G0 transition +
                                                is-amaintenance of protein location to spindle pole body
                                                is-amaintenance of sister chromatid cohesion +
                                                is-ameiotic cell cycle process +
                                                is-amicrotubule anchoring at spindle pole body +
                                                is-amitotic cell cycle process +
                                                is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                                negatively-regulatesnegative regulation of cell cycle process +
                                                is-anuclear chromosome segregation +
                                                positively-regulatespositive regulation of cell cycle process +
                                                is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                                is-are-entry into mitotic cell cycle +
                                                regulatesregulation of cell cycle process +
                                                is-aregulation of syncytial blastoderm mitotic cell cycle +
                                                is-asignal transduction involved in DNA damage checkpoint +
                                                is-asister chromatid cohesion +
                                                is-aspindle elongation +
                                                is-aspindle localization +
                                                is-aspindle midzone assembly +
                                                is-aspindle organization +
                                                is-aspindle pole body organization +
                                                is-aspindle pole body separation +
                                                is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                                is-atelomere maintenance via semi-conservative replication +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-achromosome segregation
                                        part-ofchromosome separation [GO:0051304] (65 genes, 84 annotations)
                                                part-ofcentromere separation +
                                                is-ameiotic chromosome separation +
                                                is-amitotic sister chromatid separation +
                                        negatively-regulatesnegative regulation of chromosome segregation +
                                        is-anuclear chromosome segregation +
                                        positively-regulatespositive regulation of chromosome segregation +
                                        regulatesregulation of chromosome segregation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-aactin filament reorganization involved in cell cycle
                                                is-aactomyosin contractile ring assembly actin filament organization +
                                                is-aattachment of spindle microtubules to kinetochore +
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint +
                                                is-acell cycle DNA replication +
                                                is-acell cycle DNA replication DNA ligation +
                                                is-acell cycle DNA replication DNA unwinding +
                                                is-acell cycle DNA replication initiation +
                                                is-acell cycle DNA replication maintenance of fidelity +
                                                is-acell cycle DNA replication termination +
                                                is-acell cycle phase transition +
                                                is-acell cycle switching +
                                                is-acentriole elongation +
                                                is-acentriole replication +
                                                is-acentromere separation +
                                                is-acentrosome cycle +
                                                is-acentrosome duplication +
                                                is-acentrosome separation +
                                                is-achromosome attachment to the nuclear envelope +
                                                is-achromosome movement towards spindle pole +
                                                is-achromosome separation [GO:0051304] (65 genes, 84 annotations)
                                                        part-ofcentromere separation +
                                                        is-ameiotic chromosome separation +
                                                        is-amitotic sister chromatid separation +
                                                is-acytokinesis +
                                                is-acytokinetic process +
                                                is-adetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                is-adetection of stimulus involved in DNA replication checkpoint +
                                                is-aDNA replication preinitiation complex assembly +
                                                is-aDNA strand elongation involved in cell cycle DNA replication +
                                                is-aestablishment of sister chromatid cohesion +
                                                is-aG0 to G1 transition +
                                                is-aG1 to G0 transition +
                                                is-amaintenance of protein location to spindle pole body
                                                is-amaintenance of sister chromatid cohesion +
                                                is-ameiotic cell cycle process +
                                                is-amicrotubule anchoring at spindle pole body +
                                                is-amitotic cell cycle process +
                                                is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                                negatively-regulatesnegative regulation of cell cycle process +
                                                is-anuclear chromosome segregation +
                                                positively-regulatespositive regulation of cell cycle process +
                                                is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                                is-are-entry into mitotic cell cycle +
                                                regulatesregulation of cell cycle process +
                                                is-aregulation of syncytial blastoderm mitotic cell cycle +
                                                is-asignal transduction involved in DNA damage checkpoint +
                                                is-asister chromatid cohesion +
                                                is-aspindle elongation +
                                                is-aspindle localization +
                                                is-aspindle midzone assembly +
                                                is-aspindle organization +
                                                is-aspindle pole body organization +
                                                is-aspindle pole body separation +
                                                is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                                is-atelomere maintenance via semi-conservative replication +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-achromosome segregation
                                        part-ofchromosome separation [GO:0051304] (65 genes, 84 annotations)
                                                part-ofcentromere separation +
                                                is-ameiotic chromosome separation +
                                                is-amitotic sister chromatid separation +
                                        negatively-regulatesnegative regulation of chromosome segregation +
                                        is-anuclear chromosome segregation +
                                        positively-regulatespositive regulation of chromosome segregation +
                                        regulatesregulation of chromosome segregation +


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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory