About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:leukocyte tethering or rolling
GO id:GO:0050901
Definition:Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological adhesion
                        is-acell adhesion
                                is-asingle organism cell adhesion
                                        is-asingle organismal cell-cell adhesion
                                                is-aleukocyte cell-cell adhesion
                                                        is-aB cell adhesion
                                                        is-aleukocyte activation-dependent arrest
                                                        is-aleukocyte aggregation +
                                                        is-aleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                                        is-alymphocyte adhesion to endothelial cell of high endothelial venule
                                                        negatively-regulatesnegative regulation of leukocyte cell-cell adhesion +
                                                        positively-regulatespositive regulation of leukocyte cell-cell adhesion +
                                                        regulatesregulation of leukocyte cell-cell adhesion +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular component movement
                                        is-acell motility
                                                is-acell migration
                                                        is-aleukocyte migration
                                                                is-acellular extravasation
                                                                        part-ofdiapedesis +
                                                                        is-aeosinophil extravasation +
                                                                        part-ofleukocyte activation-dependent arrest
                                                                        part-ofleukocyte adhesive activation
                                                                        part-ofleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                                                        is-amonocyte extravasation +
                                                                        negatively-regulatesnegative regulation of cellular extravasation +
                                                                        is-aneutrophil extravasation +
                                                                        positively-regulatespositive regulation of cellular extravasation +
                                                                        regulatesregulation of cellular extravasation +
                                                                        is-aT cell extravasation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aleukocyte migration
                                is-acellular extravasation
                                        part-ofdiapedesis +
                                        is-aeosinophil extravasation +
                                        part-ofleukocyte activation-dependent arrest
                                        part-ofleukocyte adhesive activation
                                        part-ofleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                        is-amonocyte extravasation +
                                        negatively-regulatesnegative regulation of cellular extravasation +
                                        is-aneutrophil extravasation +
                                        positively-regulatespositive regulation of cellular extravasation +
                                        regulatesregulation of cellular extravasation +
                                        is-aT cell extravasation +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-alocalization of cell
                                part-ofcell motility
                                        is-acell migration
                                                is-aleukocyte migration
                                                        is-acellular extravasation
                                                                part-ofdiapedesis +
                                                                is-aeosinophil extravasation +
                                                                part-ofleukocyte activation-dependent arrest
                                                                part-ofleukocyte adhesive activation
                                                                part-ofleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                                                is-amonocyte extravasation +
                                                                negatively-regulatesnegative regulation of cellular extravasation +
                                                                is-aneutrophil extravasation +
                                                                positively-regulatespositive regulation of cellular extravasation +
                                                                regulatesregulation of cellular extravasation +
                                                                is-aT cell extravasation +


Gene_Ontology
        is-abiological_process
                is-alocomotion
                        is-acell motility
                                is-acell migration
                                        is-aleukocyte migration
                                                is-acellular extravasation
                                                        part-ofdiapedesis +
                                                        is-aeosinophil extravasation +
                                                        part-ofleukocyte activation-dependent arrest
                                                        part-ofleukocyte adhesive activation
                                                        part-ofleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                                        is-amonocyte extravasation +
                                                        negatively-regulatesnegative regulation of cellular extravasation +
                                                        is-aneutrophil extravasation +
                                                        positively-regulatespositive regulation of cellular extravasation +
                                                        regulatesregulation of cellular extravasation +
                                                        is-aT cell extravasation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism cell adhesion
                                is-asingle organismal cell-cell adhesion
                                        is-aleukocyte cell-cell adhesion
                                                is-aB cell adhesion
                                                is-aleukocyte activation-dependent arrest
                                                is-aleukocyte aggregation +
                                                is-aleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                                is-alymphocyte adhesion to endothelial cell of high endothelial venule
                                                negatively-regulatesnegative regulation of leukocyte cell-cell adhesion +
                                                positively-regulatespositive regulation of leukocyte cell-cell adhesion +
                                                regulatesregulation of leukocyte cell-cell adhesion +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular component movement
                                        is-acell motility
                                                is-acell migration
                                                        is-aleukocyte migration
                                                                is-acellular extravasation
                                                                        part-ofdiapedesis +
                                                                        is-aeosinophil extravasation +
                                                                        part-ofleukocyte activation-dependent arrest
                                                                        part-ofleukocyte adhesive activation
                                                                        part-ofleukocyte tethering or rolling [GO:0050901] (10 genes, 10 annotations)
                                                                        is-amonocyte extravasation +
                                                                        negatively-regulatesnegative regulation of cellular extravasation +
                                                                        is-aneutrophil extravasation +
                                                                        positively-regulatespositive regulation of cellular extravasation +
                                                                        regulatesregulation of cellular extravasation +
                                                                        is-aT cell extravasation +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory