| GO term: | leukocyte tethering or rolling |
| GO id: | GO:0050901 |
| Definition: | Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). |
| Number of paths to term: | 8 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological adhesioncell adhesioncell-cell adhesionleukocyte cell-cell adhesionB cell adhesionleukocyte activation-dependent arrestleukocyte aggregation +leukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)lymphocyte adhesion to endothelial cell of high endothelial venulebiological_processcellular processsingle-organism cellular processcell adhesioncell-cell adhesionleukocyte cell-cell adhesionB cell adhesionleukocyte activation-dependent arrestleukocyte aggregation +leukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)lymphocyte adhesion to endothelial cell of high endothelial venulebiological_processcellular processsingle-organism cellular processcellular component movementcell motilitycell migrationleukocyte migrationcellular extravasationdiapedesis +eosinophil extravasation +leukocyte activation-dependent arrestleukocyte adhesive activationleukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)monocyte extravasation +negative regulation of cellular extravasation +neutrophil extravasation +positive regulation of cellular extravasation +regulation of cellular extravasation +T cell extravasation +biological_processimmune system processleukocyte migrationcellular extravasationdiapedesis +eosinophil extravasation +leukocyte activation-dependent arrestleukocyte adhesive activationleukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)monocyte extravasation +negative regulation of cellular extravasation +neutrophil extravasation +positive regulation of cellular extravasation +regulation of cellular extravasation +T cell extravasation +biological_processlocalizationlocalization of cellcell motilitycell migrationleukocyte migrationcellular extravasationdiapedesis +eosinophil extravasation +leukocyte activation-dependent arrestleukocyte adhesive activationleukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)monocyte extravasation +negative regulation of cellular extravasation +neutrophil extravasation +positive regulation of cellular extravasation +regulation of cellular extravasation +T cell extravasation +biological_processlocomotioncell motilitycell migrationleukocyte migrationcellular extravasationdiapedesis +eosinophil extravasation +leukocyte activation-dependent arrestleukocyte adhesive activationleukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)monocyte extravasation +negative regulation of cellular extravasation +neutrophil extravasation +positive regulation of cellular extravasation +regulation of cellular extravasation +T cell extravasation +biological_processsingle-organism processsingle-organism cellular processcell adhesioncell-cell adhesionleukocyte cell-cell adhesionB cell adhesionleukocyte activation-dependent arrestleukocyte aggregation +leukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)lymphocyte adhesion to endothelial cell of high endothelial venulebiological_processsingle-organism processsingle-organism cellular processcellular component movementcell motilitycell migrationleukocyte migrationcellular extravasationdiapedesis +eosinophil extravasation +leukocyte activation-dependent arrestleukocyte adhesive activationleukocyte tethering or rolling [GO:0050901] (8 genes, 8 annotations)monocyte extravasation +negative regulation of cellular extravasation +neutrophil extravasation +positive regulation of cellular extravasation +regulation of cellular extravasation +T cell extravasation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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