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Gene Ontology Browser
Term Detail
GO term:progesterone 5-alpha-reductase activity
Synonym: 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity
Synonym: delta4-steroid 5alpha-reductase (progesterone)
Synonym: progesterone 5alpha-reductase activity
Synonym: progesterone 5a-reductase activity
Synonym: steroid 5-alpha-reductase activity
GO id:GO:0050213
Definition:Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on the CH-CH group of donors
                                        is-aoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
                                                is-a(+)-pulegone reductase, (+)-isomenthone as substrate, activity
                                                is-a(+)-pulegone reductase, (-)-menthone as substrate, activity
                                                is-a(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity
                                                is-a1,2-dihydrovomilenine reductase activity
                                                is-a1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
                                                is-a1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity
                                                is-a11-hydroxythromboxane B2 dehydrogenase activity
                                                is-a12-hydroxyheptadecatrienoic acid synthase activity
                                                is-a12-oxophytodienoate reductase activity
                                                is-a15-oxoprostaglandin 13-oxidase activity
                                                is-a2'-hydroxydaidzein reductase activity
                                                is-a2'-hydroxyisoflavone reductase activity
                                                is-a2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
                                                is-a2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
                                                is-a2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
                                                is-a2,4-dichlorobenzoyl-CoA reductase activity
                                                is-a2,4-dienoyl-CoA reductase (NADPH) activity
                                                is-a2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
                                                is-a2-alkenal reductase (NADP+) activity
                                                is-a2-alkenal reductase [NAD(P)] activity
                                                is-a2-coumarate reductase activity
                                                is-a2-enoate reductase activity
                                                is-a2-hexadecenal reductase activity
                                                is-a2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity
                                                is-a2-methyl-branched-chain-enoyl-CoA reductase activity
                                                is-a3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity
                                                is-a3-methyleneoxindole reductase activity
                                                is-a4-hydroxy-tetrahydrodipicolinate reductase
                                                is-a5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
                                                is-a7-dehydrocholesterol reductase activity
                                                is-aacryloyl-CoA reductase (NADP+) activity
                                                is-aacryloyl-CoA reductase activity
                                                is-aacyl-CoA dehydrogenase (NADP+) activity
                                                is-aalpha-santonin 1,2-reductase activity
                                                is-aanthocyanidin reductase activity
                                                is-aarogenate dehydrogenase (NADP+) activity
                                                is-aarogenate dehydrogenase [NAD(P)+] activity
                                                is-abenzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity
                                                is-abenzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity
                                                is-abeta-nitroacrylate reductase activity
                                                is-abiliverdin reductase activity
                                                is-abiochanin-A reductase activity
                                                is-acinnamate reductase activity
                                                is-acis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
                                                is-acis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
                                                is-acis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
                                                is-acis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
                                                is-acis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
                                                is-acis-2,3-dihydrodiol DDT dehydrogenase activity
                                                is-acis-2-enoyl-CoA reductase (NADPH) activity
                                                is-acis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
                                                is-acis-chlorobenzene dihydrodiol dehydrogenase activity
                                                is-acis-dihydroethylcatechol dehydrogenase activity
                                                is-acitronellyl-CoA dehydrogenase activity
                                                is-acortisone alpha-reductase activity
                                                is-acucurbitacin delta23-reductase activity
                                                is-acyclohexadienyl dehydrogenase activity
                                                is-adelta14-sterol reductase activity
                                                is-adelta24(24-1) sterol reductase activity
                                                is-adelta24-sterol reductase activity
                                                is-adibenzothiophene dihydrodiol dehydrogenase activity
                                                is-adihydropyrimidine dehydrogenase (NADP+) activity
                                                is-adihydrouracil dehydrogenase (NAD+) activity
                                                is-adivinyl chlorophyllide a 8-vinyl-reductase activity
                                                is-aenone reductase activity +
                                                is-aenoyl-[acyl-carrier-protein] reductase (NADH) activity
                                                is-aenoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
                                                is-aenoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
                                                is-aenoyl-[acyl-carrier-protein] reductase activity
                                                is-afumarate reductase (NADH) activity
                                                is-ageissoschizine dehydrogenase activity
                                                is-akynurenate-7,8-dihydrodiol dehydrogenase activity
                                                is-alariciresinol reductase activity
                                                is-amaleylacetate reductase activity
                                                is-amenthone dehydrogenase activity
                                                is-ameso-tartrate dehydrogenase activity
                                                is-aNADPH-dependent curcumin reductase activity
                                                is-aNADPH-dependent dihydrocurcumin reductase activity
                                                is-aorotate reductase (NADH) activity
                                                is-aorotate reductase (NADPH) activity
                                                is-aphloroglucinol reductase activity
                                                is-aphosphatidylcholine desaturase activity
                                                is-aphthalate 3,4-cis-dihydrodiol dehydrogenase activity
                                                is-aphthalate 4,5-cis-dihydrodiol dehydrogenase activity
                                                is-apimeloyl-CoA dehydrogenase activity
                                                is-apinoresinol reductase activity
                                                is-aprecorrin-2 dehydrogenase activity
                                                is-aprecorrin-6A reductase activity
                                                is-aprephenate dehydrogenase (NADP+) activity
                                                is-aprephenate dehydrogenase activity
                                                is-aprogesterone 5-alpha-reductase activity [GO:0050213] (0 genes, 0 annotations)
                                                is-aprotochlorophyllide reductase activity
                                                is-atrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
                                                is-atrans-1,2-dihydrodiolphenanthrene dehydrogenase activity
                                                is-atrans-2-enoyl-CoA reductase (NAD+) activity
                                                is-atrans-2-enoyl-CoA reductase (NADPH) activity
                                                is-atrans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity
                                                is-axanthommatin reductase activity
                                                is-azeatin reductase activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory