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Gene Ontology Browser
Term Detail
GO term:autophagic cell death
Synonym: autophagic death
Synonym: programmed cell death by autophagy
Synonym: programmed cell death by macroautophagy
Synonym: type II programmed cell death
GO id:GO:0048102
Definition:A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagic vacuoles, with little or no uptake by phagocytic cells.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process +
                                                is-aautophagic cell death [GO:0048102] (6 genes, 6 annotations)
                                                        is-asalivary gland cell autophagic cell death +
                                                is-acornification
                                                is-adevelopmental programmed cell death +
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process +
                                                is-aautophagic cell death [GO:0048102] (6 genes, 6 annotations)
                                                        is-asalivary gland cell autophagic cell death +
                                                is-acornification
                                                is-adevelopmental programmed cell death +
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process +
                                                is-aautophagic cell death [GO:0048102] (6 genes, 6 annotations)
                                                        is-asalivary gland cell autophagic cell death +
                                                is-acornification
                                                is-adevelopmental programmed cell death +
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory