| GO term: | autophagic cell death |
| Synonym: | autophagic death |
| Synonym: | programmed cell death by autophagy |
| Synonym: | programmed cell death by macroautophagy |
| Synonym: | type II programmed cell death |
| GO id: | GO:0048102 |
| Definition: | A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagic vacuoles, with little or no uptake by phagocytic cells. |
| Number of paths to term: | 3 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic process +autophagic cell death [GO:0048102] (6 genes, 6 annotations)salivary gland cell autophagic cell death +cornificationdevelopmental programmed cell death +host programmed cell death induced by symbiont +negative regulation of programmed cell death +positive regulation of programmed cell death +programmed cell death in response to reactive oxygen species +programmed necrotic cell death +pyroptosisregulation of programmed cell death +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic process +autophagic cell death [GO:0048102] (6 genes, 6 annotations)salivary gland cell autophagic cell death +cornificationdevelopmental programmed cell death +host programmed cell death induced by symbiont +negative regulation of programmed cell death +positive regulation of programmed cell death +programmed cell death in response to reactive oxygen species +programmed necrotic cell death +pyroptosisregulation of programmed cell death +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic process +autophagic cell death [GO:0048102] (6 genes, 6 annotations)salivary gland cell autophagic cell death +cornificationdevelopmental programmed cell death +host programmed cell death induced by symbiont +negative regulation of programmed cell death +positive regulation of programmed cell death +programmed cell death in response to reactive oxygen species +programmed necrotic cell death +pyroptosisregulation of programmed cell death +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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