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Term Detail
GO term:autophagic cell death
Synonym: autophagic death
Synonym: autosis
Synonym: programmed cell death by autophagy
Synonym: programmed cell death by macroautophagy
Synonym: type II programmed cell death
GO id:GO:0048102
Definition:A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
CommentsThe precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process +
                                                is-aautolysis
                                                is-aautophagic cell death [GO:0048102] (7 genes, 8 annotations)
                                                        negatively-regulatesnegative regulation of autophagic cell death
                                                        positively-regulatespositive regulation of autophagic cell death
                                                        regulatesregulation of autophagic cell death +
                                                        is-asalivary gland cell autophagic cell death +
                                                is-acornification
                                                is-aferroptosis
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed cell death involved in cell development +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process +
                                                is-aautolysis
                                                is-aautophagic cell death [GO:0048102] (7 genes, 8 annotations)
                                                        negatively-regulatesnegative regulation of autophagic cell death
                                                        positively-regulatespositive regulation of autophagic cell death
                                                        regulatesregulation of autophagic cell death +
                                                        is-asalivary gland cell autophagic cell death +
                                                is-acornification
                                                is-aferroptosis
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed cell death involved in cell development +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory