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Gene Ontology Browser
Term Detail
GO term:oxoglutarate dehydrogenase complex
Synonym: dihydrolipoamide S-succinyltransferase complex
GO id:GO:0045252
Definition:A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
CommentsSee also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
Number of paths to term: 14

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-atricarboxylic acid cycle enzyme complex
                                                                        is-adihydrolipoyl dehydrogenase complex
                                                                                is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                                is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                                                        is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-atricarboxylic acid cycle enzyme complex
                                                                is-adihydrolipoyl dehydrogenase complex
                                                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-atricarboxylic acid cycle enzyme complex
                                                                is-adihydrolipoyl dehydrogenase complex
                                                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-atricarboxylic acid cycle enzyme complex
                                                        is-adihydrolipoyl dehydrogenase complex
                                                                is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                                        is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aoxidoreductase complex
                                        is-adihydrolipoyl dehydrogenase complex
                                                is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                        is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofoxidoreductase complex
                                is-adihydrolipoyl dehydrogenase complex
                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-atricarboxylic acid cycle enzyme complex
                                                                is-adihydrolipoyl dehydrogenase complex
                                                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-atricarboxylic acid cycle enzyme complex
                                                        is-adihydrolipoyl dehydrogenase complex
                                                                is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                                        is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-atricarboxylic acid cycle enzyme complex
                                                        is-adihydrolipoyl dehydrogenase complex
                                                                is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                                is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                                        is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-atricarboxylic acid cycle enzyme complex
                                                is-adihydrolipoyl dehydrogenase complex
                                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aoxidoreductase complex
                                is-adihydrolipoyl dehydrogenase complex
                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-aoxidoreductase complex
                                                is-adihydrolipoyl dehydrogenase complex
                                                        is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                        is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                        is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                                is-acytosolic oxoglutarate dehydrogenase complex
                                                                is-amitochondrial oxoglutarate dehydrogenase complex


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-atransferase complex
                                                is-a1,3-beta-D-glucan synthase complex
                                                is-a4-aminobutyrate transaminase complex
                                                is-a6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
                                                is-a6-phosphofructokinase complex
                                                is-a7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex
                                                is-aacetate CoA-transferase complex +
                                                is-aacetolactate synthase complex
                                                is-aacetyltransferase complex +
                                                is-aadenylyltransferase complex +
                                                is-aalpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
                                                is-aaspartate carbamoyltransferase complex
                                                is-aCAAX-protein geranylgeranyltransferase complex
                                                is-acellulose synthase complex +
                                                is-acreatine kinase complex +
                                                is-adecaprenyl diphosphate synthase complex +
                                                is-aDNA polymerase complex +
                                                is-aendoplasmic reticulum palmitoyltransferase complex +
                                                is-afatty acid elongase complex
                                                is-afatty-acyl-CoA synthase complex
                                                is-aimidazoleglycerol-phosphate synthase complex
                                                is-ainositol phosphoceramide synthase complex
                                                is-airon-sulfur cluster transfer complex
                                                is-amannosyltransferase complex +
                                                is-amethionine adenosyltransferase complex
                                                is-amethyl coenzyme M reductase complex
                                                is-amethyltransferase complex +
                                                is-aoligosaccharyltransferase complex +
                                                is-aornithine carbamoyltransferase complex
                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                        is-amitochondrial oxoglutarate dehydrogenase complex
                                                is-aphosphatidylinositol 3-kinase complex +
                                                is-apolyphosphate kinase complex
                                                is-aprotein farnesyltransferase complex
                                                is-aprotein kinase complex +
                                                is-aprotein N-acetylglucosaminyltransferase complex
                                                is-aprotein-N(PI)-phosphohistidine-sugar phosphotransferase complex
                                                is-apyruvate kinase complex
                                                is-aRab-protein geranylgeranyltransferase complex
                                                is-ariboflavin synthase complex
                                                is-aribose phosphate diphosphokinase complex
                                                is-aRNA polymerase complex +
                                                is-aserine-pyruvate aminotransferase complex
                                                is-asignal peptidase complex
                                                is-asulfurtransferase complex +
                                                is-aubiquitin ligase complex +
                                                is-aUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-atricarboxylic acid cycle enzyme complex
                                        is-adihydrolipoyl dehydrogenase complex
                                                is-acytosolic alpha-ketoglutarate dehydrogenase complex
                                                is-amitochondrial alpha-ketoglutarate dehydrogenase complex +
                                                is-aoxoglutarate dehydrogenase complex [GO:0045252] (3 genes, 3 annotations)
                                                        is-acytosolic oxoglutarate dehydrogenase complex
                                                        is-amitochondrial oxoglutarate dehydrogenase complex


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory