About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:cAMP response element binding
Synonym: cAMP-responsive element binding
Synonym: CRE binding
Synonym: cyclic AMP response element binding
Synonym: cyclic-AMP response element binding
Synonym: cyclic-AMP-responsive element binding
GO id:GO:0035497
Definition:Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
CommentsNote that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding [GO:0035497] (6 genes, 7 annotations)
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding [GO:0035497] (6 genes, 7 annotations)
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding [GO:0035497] (6 genes, 7 annotations)
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding [GO:0035497] (6 genes, 7 annotations)
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory