About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:hippo signaling
Synonym: hippo signaling cascade
Synonym: hippo signaling pathway
Synonym: hippo signalling cascade
Synonym: hippo signal transduction
Synonym: Salvador-Warts-Hippo signaling pathway
Synonym: SWH pathway
GO id:GO:0035329
Definition:The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                                negatively-regulatesnegative regulation of hippo signaling
                                                                positively-regulatespositive regulation of hippo signaling
                                                                regulatesregulation of hippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                        negatively-regulatesnegative regulation of hippo signaling
                                                        positively-regulatespositive regulation of hippo signaling
                                                        regulatesregulation of hippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                        negatively-regulatesnegative regulation of hippo signaling
                                                        positively-regulatespositive regulation of hippo signaling
                                                        regulatesregulation of hippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                                negatively-regulatesnegative regulation of hippo signaling
                                                                positively-regulatespositive regulation of hippo signaling
                                                                regulatesregulation of hippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                        negatively-regulatesnegative regulation of hippo signaling
                                                        positively-regulatespositive regulation of hippo signaling
                                                        regulatesregulation of hippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                        negatively-regulatesnegative regulation of hippo signaling
                                                        positively-regulatespositive regulation of hippo signaling
                                                        regulatesregulation of hippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                        negatively-regulatesnegative regulation of hippo signaling
                                                        positively-regulatespositive regulation of hippo signaling
                                                        regulatesregulation of hippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                        negatively-regulatesnegative regulation of hippo signaling
                                                        positively-regulatespositive regulation of hippo signaling
                                                        regulatesregulation of hippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling [GO:0035329] (26 genes, 34 annotations)
                                                                negatively-regulatesnegative regulation of hippo signaling
                                                                positively-regulatespositive regulation of hippo signaling
                                                                regulatesregulation of hippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory