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Gene Ontology Browser
Term Detail
GO term:collagen biosynthetic process
Synonym: collagen anabolism
Synonym: collagen biosynthesis
Synonym: collagen formation
Synonym: collagen synthesis
GO id:GO:0032964
Definition:The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
Number of paths to term: 11

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-aorganic substance biosynthetic process
                                        is-amacromolecule biosynthetic process
                                                is-aaminoglycan biosynthetic process +
                                                is-aamylopectin biosynthetic process
                                                is-abiotin carboxyl carrier protein biosynthetic process
                                                is-acellular macromolecule biosynthetic process +
                                                is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                        negatively-regulatesnegative regulation of collagen biosynthetic process
                                                        positively-regulatespositive regulation of collagen biosynthetic process
                                                        regulatesregulation of collagen biosynthetic process +
                                                is-acutin biosynthetic process +
                                                is-aimmunoglobulin biosynthetic process +
                                                is-aintegrin biosynthetic process +
                                                is-amaintenance of translational fidelity
                                                is-aMHC class I biosynthetic process +
                                                is-aMHC class II biosynthetic process +
                                                negatively-regulatesnegative regulation of macromolecule biosynthetic process +
                                                is-anitric-oxide synthase biosynthetic process +
                                                is-apolysaccharide biosynthetic process +
                                                positively-regulatespositive regulation of macromolecule biosynthetic process +
                                                part-ofprosthetic group biosynthetic process +
                                                is-areceptor biosynthetic process +
                                                regulatesregulation of macromolecule biosynthetic process +
                                                is-aRNA biosynthetic process +
                                                is-aS100 alpha biosynthetic process
                                                is-aS100 beta biosynthetic process
                                                is-athymidylate synthase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-asingle-organism biosynthetic process
                                        is-a(R)-mandelate catabolic process to catechol
                                        is-aacetate ester biosynthetic process +
                                        is-aacetyl-CoA biosynthetic process from acetate
                                        is-aacetyl-CoA biosynthetic process from ethanol
                                        is-aacetyl-CoA biosynthetic process from pantothenate
                                        is-aacetyl-CoA biosynthetic process from pyruvate +
                                        is-aaldehyde biosynthetic process +
                                        is-aalkane biosynthetic process +
                                        is-aalkanesulfonate biosynthetic process
                                        is-aalkyne biosynthetic process
                                        is-aaminoglycan biosynthetic process +
                                        is-aaustinol biosynthetic process +
                                        is-acarbohydrate biosynthetic process +
                                        is-acarbon fixation by acetyl-CoA pathway
                                        is-acell cycle DNA replication +
                                        is-acellular lactam biosynthetic process +
                                        is-acoenzyme M biosynthetic process
                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                regulatesregulation of collagen biosynthetic process +
                                        is-acyanate biosynthetic process
                                        is-acyanide biosynthetic process
                                        is-aD-arabinose catabolic process to xylulose 5-phosphate
                                        is-aD-arabitol catabolic process to xylulose 5-phosphate
                                        is-adopamine biosynthetic process from tyrosine
                                        is-aeggshell chorion gene amplification
                                        is-aether biosynthetic process +
                                        is-afatty acid derivative biosynthetic process +
                                        is-afermentative hydrogen production
                                        is-aglucuronate catabolic process to xylulose 5-phosphate
                                        is-aglutathione derivative biosynthetic process +
                                        is-aglycosyl compound biosynthetic process +
                                        is-aheparan sulfate proteoglycan biosynthetic process +
                                        is-aindoleacetic acid conjugate biosynthetic process +
                                        is-airon incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
                                        is-aL-arabinose catabolic process to xylulose 5-phosphate
                                        is-aL-arabitol catabolic process to xylulose 5-phosphate
                                        is-aL-xylitol catabolic process to xylulose 5-phosphate
                                        is-alipid biosynthetic process +
                                        is-ameiotic DNA repair synthesis +
                                        is-amitochondrial translation +
                                        is-anucleobase biosynthetic process +
                                        is-anucleoside phosphate biosynthetic process +
                                        is-apigment biosynthetic process +
                                        is-aplastid translation
                                        is-apoly(hydroxyalkanoate) biosynthetic process from fatty acid
                                        is-apoly(hydroxyalkanoate) biosynthetic process from glucose
                                        is-apolyphosphate biosynthetic process
                                        is-aprotoporphyrinogen IX biosynthetic process from glycine
                                        is-aputrescine biosynthetic process from arginine +
                                        is-aputrescine biosynthetic process from ornithine
                                        is-apyridoxal phosphate biosynthetic process from pyridoxamine
                                        is-aribitol catabolic process to xylulose 5-phosphate
                                        is-asecondary metabolite biosynthetic process +
                                        is-aserotonin biosynthetic process from tryptophan +
                                        is-asmall molecule biosynthetic process +
                                        is-atartrate biosynthetic process
                                        is-atelomere maintenance via telomerase +
                                        is-atetrapyrrole biosynthetic process from glutamate +
                                        is-atetrapyrrole biosynthetic process from glycine and succinyl-CoA +
                                        is-atranscription from mitochondrial promoter +
                                        is-atranscription from plastid promoter +
                                        is-atranslesion synthesis +
                                        is-auracil salvage
                                        is-aurea cycle
                                        is-avibriobactin biosynthetic process


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-amacromolecule biosynthetic process
                                                is-aaminoglycan biosynthetic process +
                                                is-aamylopectin biosynthetic process
                                                is-abiotin carboxyl carrier protein biosynthetic process
                                                is-acellular macromolecule biosynthetic process +
                                                is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                        negatively-regulatesnegative regulation of collagen biosynthetic process
                                                        positively-regulatespositive regulation of collagen biosynthetic process
                                                        regulatesregulation of collagen biosynthetic process +
                                                is-acutin biosynthetic process +
                                                is-aimmunoglobulin biosynthetic process +
                                                is-aintegrin biosynthetic process +
                                                is-amaintenance of translational fidelity
                                                is-aMHC class I biosynthetic process +
                                                is-aMHC class II biosynthetic process +
                                                negatively-regulatesnegative regulation of macromolecule biosynthetic process +
                                                is-anitric-oxide synthase biosynthetic process +
                                                is-apolysaccharide biosynthetic process +
                                                positively-regulatespositive regulation of macromolecule biosynthetic process +
                                                part-ofprosthetic group biosynthetic process +
                                                is-areceptor biosynthetic process +
                                                regulatesregulation of macromolecule biosynthetic process +
                                                is-aRNA biosynthetic process +
                                                is-aS100 alpha biosynthetic process
                                                is-aS100 beta biosynthetic process
                                                is-athymidylate synthase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-amulticellular organismal macromolecule metabolic process
                                                is-acollagen metabolic process
                                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                                regulatesregulation of collagen biosynthetic process +
                                                        is-acollagen catabolic process +
                                                        negatively-regulatesnegative regulation of collagen metabolic process +
                                                        positively-regulatespositive regulation of collagen metabolic process +
                                                        regulatesregulation of collagen metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic substance biosynthetic process
                                        is-amacromolecule biosynthetic process
                                                is-aaminoglycan biosynthetic process +
                                                is-aamylopectin biosynthetic process
                                                is-abiotin carboxyl carrier protein biosynthetic process
                                                is-acellular macromolecule biosynthetic process +
                                                is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                        negatively-regulatesnegative regulation of collagen biosynthetic process
                                                        positively-regulatespositive regulation of collagen biosynthetic process
                                                        regulatesregulation of collagen biosynthetic process +
                                                is-acutin biosynthetic process +
                                                is-aimmunoglobulin biosynthetic process +
                                                is-aintegrin biosynthetic process +
                                                is-amaintenance of translational fidelity
                                                is-aMHC class I biosynthetic process +
                                                is-aMHC class II biosynthetic process +
                                                negatively-regulatesnegative regulation of macromolecule biosynthetic process +
                                                is-anitric-oxide synthase biosynthetic process +
                                                is-apolysaccharide biosynthetic process +
                                                positively-regulatespositive regulation of macromolecule biosynthetic process +
                                                part-ofprosthetic group biosynthetic process +
                                                is-areceptor biosynthetic process +
                                                regulatesregulation of macromolecule biosynthetic process +
                                                is-aRNA biosynthetic process +
                                                is-aS100 alpha biosynthetic process
                                                is-aS100 beta biosynthetic process
                                                is-athymidylate synthase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-amulticellular organismal metabolic process
                                        is-amulticellular organismal macromolecule metabolic process
                                                is-acollagen metabolic process
                                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                                regulatesregulation of collagen biosynthetic process +
                                                        is-acollagen catabolic process +
                                                        negatively-regulatesnegative regulation of collagen metabolic process +
                                                        positively-regulatespositive regulation of collagen metabolic process +
                                                        regulatesregulation of collagen metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-asingle-organism biosynthetic process
                                        is-a(R)-mandelate catabolic process to catechol
                                        is-aacetate ester biosynthetic process +
                                        is-aacetyl-CoA biosynthetic process from acetate
                                        is-aacetyl-CoA biosynthetic process from ethanol
                                        is-aacetyl-CoA biosynthetic process from pantothenate
                                        is-aacetyl-CoA biosynthetic process from pyruvate +
                                        is-aaldehyde biosynthetic process +
                                        is-aalkane biosynthetic process +
                                        is-aalkanesulfonate biosynthetic process
                                        is-aalkyne biosynthetic process
                                        is-aaminoglycan biosynthetic process +
                                        is-aaustinol biosynthetic process +
                                        is-acarbohydrate biosynthetic process +
                                        is-acarbon fixation by acetyl-CoA pathway
                                        is-acell cycle DNA replication +
                                        is-acellular lactam biosynthetic process +
                                        is-acoenzyme M biosynthetic process
                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                regulatesregulation of collagen biosynthetic process +
                                        is-acyanate biosynthetic process
                                        is-acyanide biosynthetic process
                                        is-aD-arabinose catabolic process to xylulose 5-phosphate
                                        is-aD-arabitol catabolic process to xylulose 5-phosphate
                                        is-adopamine biosynthetic process from tyrosine
                                        is-aeggshell chorion gene amplification
                                        is-aether biosynthetic process +
                                        is-afatty acid derivative biosynthetic process +
                                        is-afermentative hydrogen production
                                        is-aglucuronate catabolic process to xylulose 5-phosphate
                                        is-aglutathione derivative biosynthetic process +
                                        is-aglycosyl compound biosynthetic process +
                                        is-aheparan sulfate proteoglycan biosynthetic process +
                                        is-aindoleacetic acid conjugate biosynthetic process +
                                        is-airon incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
                                        is-aL-arabinose catabolic process to xylulose 5-phosphate
                                        is-aL-arabitol catabolic process to xylulose 5-phosphate
                                        is-aL-xylitol catabolic process to xylulose 5-phosphate
                                        is-alipid biosynthetic process +
                                        is-ameiotic DNA repair synthesis +
                                        is-amitochondrial translation +
                                        is-anucleobase biosynthetic process +
                                        is-anucleoside phosphate biosynthetic process +
                                        is-apigment biosynthetic process +
                                        is-aplastid translation
                                        is-apoly(hydroxyalkanoate) biosynthetic process from fatty acid
                                        is-apoly(hydroxyalkanoate) biosynthetic process from glucose
                                        is-apolyphosphate biosynthetic process
                                        is-aprotoporphyrinogen IX biosynthetic process from glycine
                                        is-aputrescine biosynthetic process from arginine +
                                        is-aputrescine biosynthetic process from ornithine
                                        is-apyridoxal phosphate biosynthetic process from pyridoxamine
                                        is-aribitol catabolic process to xylulose 5-phosphate
                                        is-asecondary metabolite biosynthetic process +
                                        is-aserotonin biosynthetic process from tryptophan +
                                        is-asmall molecule biosynthetic process +
                                        is-atartrate biosynthetic process
                                        is-atelomere maintenance via telomerase +
                                        is-atetrapyrrole biosynthetic process from glutamate +
                                        is-atetrapyrrole biosynthetic process from glycine and succinyl-CoA +
                                        is-atranscription from mitochondrial promoter +
                                        is-atranscription from plastid promoter +
                                        is-atranslesion synthesis +
                                        is-auracil salvage
                                        is-aurea cycle
                                        is-avibriobactin biosynthetic process


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal metabolic process
                                        is-amulticellular organismal macromolecule metabolic process
                                                is-acollagen metabolic process
                                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                                regulatesregulation of collagen biosynthetic process +
                                                        is-acollagen catabolic process +
                                                        negatively-regulatesnegative regulation of collagen metabolic process +
                                                        positively-regulatespositive regulation of collagen metabolic process +
                                                        regulatesregulation of collagen metabolic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal metabolic process
                                        is-amulticellular organismal macromolecule metabolic process
                                                is-acollagen metabolic process
                                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                                regulatesregulation of collagen biosynthetic process +
                                                        is-acollagen catabolic process +
                                                        negatively-regulatesnegative regulation of collagen metabolic process +
                                                        positively-regulatespositive regulation of collagen metabolic process +
                                                        regulatesregulation of collagen metabolic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-amulticellular organismal metabolic process
                                        is-amulticellular organismal macromolecule metabolic process
                                                is-acollagen metabolic process
                                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                                regulatesregulation of collagen biosynthetic process +
                                                        is-acollagen catabolic process +
                                                        negatively-regulatesnegative regulation of collagen metabolic process +
                                                        positively-regulatespositive regulation of collagen metabolic process +
                                                        regulatesregulation of collagen metabolic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-asingle-organism biosynthetic process
                                        is-a(R)-mandelate catabolic process to catechol
                                        is-aacetate ester biosynthetic process +
                                        is-aacetyl-CoA biosynthetic process from acetate
                                        is-aacetyl-CoA biosynthetic process from ethanol
                                        is-aacetyl-CoA biosynthetic process from pantothenate
                                        is-aacetyl-CoA biosynthetic process from pyruvate +
                                        is-aaldehyde biosynthetic process +
                                        is-aalkane biosynthetic process +
                                        is-aalkanesulfonate biosynthetic process
                                        is-aalkyne biosynthetic process
                                        is-aaminoglycan biosynthetic process +
                                        is-aaustinol biosynthetic process +
                                        is-acarbohydrate biosynthetic process +
                                        is-acarbon fixation by acetyl-CoA pathway
                                        is-acell cycle DNA replication +
                                        is-acellular lactam biosynthetic process +
                                        is-acoenzyme M biosynthetic process
                                        is-acollagen biosynthetic process [GO:0032964] (35 genes, 38 annotations)
                                                negatively-regulatesnegative regulation of collagen biosynthetic process
                                                positively-regulatespositive regulation of collagen biosynthetic process
                                                regulatesregulation of collagen biosynthetic process +
                                        is-acyanate biosynthetic process
                                        is-acyanide biosynthetic process
                                        is-aD-arabinose catabolic process to xylulose 5-phosphate
                                        is-aD-arabitol catabolic process to xylulose 5-phosphate
                                        is-adopamine biosynthetic process from tyrosine
                                        is-aeggshell chorion gene amplification
                                        is-aether biosynthetic process +
                                        is-afatty acid derivative biosynthetic process +
                                        is-afermentative hydrogen production
                                        is-aglucuronate catabolic process to xylulose 5-phosphate
                                        is-aglutathione derivative biosynthetic process +
                                        is-aglycosyl compound biosynthetic process +
                                        is-aheparan sulfate proteoglycan biosynthetic process +
                                        is-aindoleacetic acid conjugate biosynthetic process +
                                        is-airon incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
                                        is-aL-arabinose catabolic process to xylulose 5-phosphate
                                        is-aL-arabitol catabolic process to xylulose 5-phosphate
                                        is-aL-xylitol catabolic process to xylulose 5-phosphate
                                        is-alipid biosynthetic process +
                                        is-ameiotic DNA repair synthesis +
                                        is-amitochondrial translation +
                                        is-anucleobase biosynthetic process +
                                        is-anucleoside phosphate biosynthetic process +
                                        is-apigment biosynthetic process +
                                        is-aplastid translation
                                        is-apoly(hydroxyalkanoate) biosynthetic process from fatty acid
                                        is-apoly(hydroxyalkanoate) biosynthetic process from glucose
                                        is-apolyphosphate biosynthetic process
                                        is-aprotoporphyrinogen IX biosynthetic process from glycine
                                        is-aputrescine biosynthetic process from arginine +
                                        is-aputrescine biosynthetic process from ornithine
                                        is-apyridoxal phosphate biosynthetic process from pyridoxamine
                                        is-aribitol catabolic process to xylulose 5-phosphate
                                        is-asecondary metabolite biosynthetic process +
                                        is-aserotonin biosynthetic process from tryptophan +
                                        is-asmall molecule biosynthetic process +
                                        is-atartrate biosynthetic process
                                        is-atelomere maintenance via telomerase +
                                        is-atetrapyrrole biosynthetic process from glutamate +
                                        is-atetrapyrrole biosynthetic process from glycine and succinyl-CoA +
                                        is-atranscription from mitochondrial promoter +
                                        is-atranscription from plastid promoter +
                                        is-atranslesion synthesis +
                                        is-auracil salvage
                                        is-aurea cycle
                                        is-avibriobactin biosynthetic process


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory