MGI 5.13 - Gene Ontology Browser

Gene Ontology Browser
Term Detail

GO term:	purine-rich negative regulatory element binding
Synonym:	PNR element binding
GO id:	GO:0032422
Definition:	Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.
Number of paths to term:	6

denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship

Gene_Ontology

molecular_function

binding

heterocyclic compound binding

nucleic acid binding

DNA binding

regulatory region DNA binding

transcription regulatory region DNA binding

bacterial-type RNA polymerase regulatory region DNA binding +

cAMP response element binding

carbohydrate response element binding

core promoter binding +

core promoter proximal region DNA binding +

E-box binding

enhancer binding +

estrogen response element binding

intronic transcription regulatory region DNA binding +

juvenile hormone response element binding

mitochondrial heavy strand promoter anti-sense binding

mitochondrial heavy strand promoter sense binding

mitochondrial light strand promoter anti-sense binding

mitochondrial light strand promoter sense binding

mitochondrial RNA polymerase regulatory region DNA binding +

N-box binding

plastid RNA polymerase regulatory region DNA binding

purine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)

retinoic acid-responsive element binding

RNA polymerase I regulatory region DNA binding +

RNA polymerase II regulatory region DNA binding +

RNA polymerase III regulatory region DNA binding +

serum response element binding

sterol response element binding

transcription regulatory region sequence-specific DNA binding +

transcription termination site DNA binding +

vitamin D response element binding

Gene_Ontology

molecular_function

binding

heterocyclic compound binding

nucleic acid binding

DNA binding

sequence-specific DNA binding

AT DNA binding

centromeric DNA binding

DNA replication origin binding

methyl-CpG binding

P-element binding

purine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)

rDNA binding +

replication fork barrier binding +

satellite DNA binding +

sequence-specific DNA binding, bending +

tDNA binding

telomeric DNA binding +

transcription regulatory region sequence-specific DNA binding +

unmethylated CpG binding

Gene_Ontology

molecular_function

binding

heterocyclic compound binding

nucleic acid binding

regulatory region nucleic acid binding

regulatory region DNA binding

transcription regulatory region DNA binding

bacterial-type RNA polymerase regulatory region DNA binding +

cAMP response element binding

carbohydrate response element binding

core promoter binding +

core promoter proximal region DNA binding +

E-box binding

enhancer binding +

estrogen response element binding

intronic transcription regulatory region DNA binding +

juvenile hormone response element binding

mitochondrial heavy strand promoter anti-sense binding

mitochondrial heavy strand promoter sense binding

mitochondrial light strand promoter anti-sense binding

mitochondrial light strand promoter sense binding

mitochondrial RNA polymerase regulatory region DNA binding +

N-box binding

plastid RNA polymerase regulatory region DNA binding

purine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)

retinoic acid-responsive element binding

RNA polymerase I regulatory region DNA binding +

RNA polymerase II regulatory region DNA binding +

RNA polymerase III regulatory region DNA binding +

serum response element binding

sterol response element binding

transcription regulatory region sequence-specific DNA binding +

transcription termination site DNA binding +

vitamin D response element binding

Gene_Ontology

molecular_function

binding

organic cyclic compound binding

nucleic acid binding

DNA binding

regulatory region DNA binding

transcription regulatory region DNA binding

bacterial-type RNA polymerase regulatory region DNA binding +

cAMP response element binding

carbohydrate response element binding

core promoter binding +

core promoter proximal region DNA binding +

E-box binding

enhancer binding +

estrogen response element binding

intronic transcription regulatory region DNA binding +

juvenile hormone response element binding

mitochondrial heavy strand promoter anti-sense binding

mitochondrial heavy strand promoter sense binding

mitochondrial light strand promoter anti-sense binding

mitochondrial light strand promoter sense binding

mitochondrial RNA polymerase regulatory region DNA binding +

N-box binding

plastid RNA polymerase regulatory region DNA binding

purine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)

retinoic acid-responsive element binding

RNA polymerase I regulatory region DNA binding +

RNA polymerase II regulatory region DNA binding +

RNA polymerase III regulatory region DNA binding +

serum response element binding

sterol response element binding

transcription regulatory region sequence-specific DNA binding +

transcription termination site DNA binding +

vitamin D response element binding

Gene_Ontology

molecular_function

binding

organic cyclic compound binding

nucleic acid binding

DNA binding

sequence-specific DNA binding

AT DNA binding

centromeric DNA binding

DNA replication origin binding

methyl-CpG binding

P-element binding

purine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)

rDNA binding +

replication fork barrier binding +

satellite DNA binding +

sequence-specific DNA binding, bending +

tDNA binding

telomeric DNA binding +

transcription regulatory region sequence-specific DNA binding +

unmethylated CpG binding

Gene_Ontology

molecular_function

binding

organic cyclic compound binding

nucleic acid binding

regulatory region nucleic acid binding

regulatory region DNA binding

transcription regulatory region DNA binding

bacterial-type RNA polymerase regulatory region DNA binding +

cAMP response element binding

carbohydrate response element binding

core promoter binding +

core promoter proximal region DNA binding +

E-box binding

enhancer binding +

estrogen response element binding

intronic transcription regulatory region DNA binding +

juvenile hormone response element binding

mitochondrial heavy strand promoter anti-sense binding

mitochondrial heavy strand promoter sense binding

mitochondrial light strand promoter anti-sense binding

mitochondrial light strand promoter sense binding

mitochondrial RNA polymerase regulatory region DNA binding +

N-box binding

plastid RNA polymerase regulatory region DNA binding

purine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)

retinoic acid-responsive element binding

RNA polymerase I regulatory region DNA binding +

RNA polymerase II regulatory region DNA binding +

RNA polymerase III regulatory region DNA binding +

serum response element binding

sterol response element binding

transcription regulatory region sequence-specific DNA binding +

transcription termination site DNA binding +

vitamin D response element binding

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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