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Gene Ontology Browser
Term Detail
GO term:purine-rich negative regulatory element binding
Synonym: PNR element binding
GO id:GO:0032422
Definition:Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-aAT DNA binding
                                                        is-acentromeric DNA binding
                                                        is-aDNA replication origin binding
                                                        is-amethyl-CpG binding
                                                        is-aP-element binding
                                                        is-apurine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)
                                                        is-arDNA binding +
                                                        is-areplication fork barrier binding +
                                                        is-asatellite DNA binding +
                                                        is-asequence-specific DNA binding, bending +
                                                        is-atDNA binding
                                                        is-atelomeric DNA binding +
                                                        is-atranscription regulatory region sequence-specific DNA binding +
                                                        is-aunmethylated CpG binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-aAT DNA binding
                                                        is-acentromeric DNA binding
                                                        is-aDNA replication origin binding
                                                        is-amethyl-CpG binding
                                                        is-aP-element binding
                                                        is-apurine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)
                                                        is-arDNA binding +
                                                        is-areplication fork barrier binding +
                                                        is-asatellite DNA binding +
                                                        is-asequence-specific DNA binding, bending +
                                                        is-atDNA binding
                                                        is-atelomeric DNA binding +
                                                        is-atranscription regulatory region sequence-specific DNA binding +
                                                        is-aunmethylated CpG binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region DNA binding +
                                                                is-acAMP response element binding
                                                                is-acarbohydrate response element binding
                                                                is-acore promoter binding +
                                                                is-acore promoter proximal region DNA binding +
                                                                is-aE-box binding
                                                                is-aenhancer binding +
                                                                is-aestrogen response element binding
                                                                is-aintronic transcription regulatory region DNA binding +
                                                                is-ajuvenile hormone response element binding
                                                                is-amitochondrial heavy strand promoter anti-sense binding
                                                                is-amitochondrial heavy strand promoter sense binding
                                                                is-amitochondrial light strand promoter anti-sense binding
                                                                is-amitochondrial light strand promoter sense binding
                                                                is-amitochondrial RNA polymerase regulatory region DNA binding +
                                                                is-aN-box binding
                                                                is-aplastid RNA polymerase regulatory region DNA binding
                                                                is-apurine-rich negative regulatory element binding [GO:0032422] (3 genes, 3 annotations)
                                                                is-aretinoic acid-responsive element binding
                                                                is-aRNA polymerase I regulatory region DNA binding +
                                                                is-aRNA polymerase II regulatory region DNA binding +
                                                                is-aRNA polymerase III regulatory region DNA binding +
                                                                is-aserum response element binding
                                                                is-asterol response element binding
                                                                is-atranscription regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site DNA binding +
                                                                is-avitamin D response element binding


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory