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Gene Ontology Browser
Term Detail
GO term:G2 DNA damage checkpoint
Synonym: G2/M transition DNA damage checkpoint
GO id:GO:0031572
Definition:A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage.
CommentsNote that this term should only be used as a grouping term for the mitotic and meiotic G2 DNA damage checkpoints, and should not be used for direct manual annotation. You should always be able to choose one of its child terms instead.
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular response to DNA damage stimulus
                                                is-aDNA damage checkpoint
                                                        part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                        is-aG1 DNA damage checkpoint +
                                                        is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                is-amitotic G2 DNA damage checkpoint +
                                                                part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                        is-amitotic DNA damage checkpoint +
                                                        negatively-regulatesnegative regulation of DNA damage checkpoint
                                                        positively-regulatespositive regulation of DNA damage checkpoint
                                                        regulatesregulation of DNA damage checkpoint +
                                                        part-ofsignal transduction involved in DNA damage checkpoint +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle checkpoint
                                                        is-aDNA integrity checkpoint
                                                                is-aDNA damage checkpoint
                                                                        part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                                        is-aG1 DNA damage checkpoint +
                                                                        is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                                part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                                is-amitotic G2 DNA damage checkpoint +
                                                                                part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                                        is-amitotic DNA damage checkpoint +
                                                                        negatively-regulatesnegative regulation of DNA damage checkpoint
                                                                        positively-regulatespositive regulation of DNA damage checkpoint
                                                                        regulatesregulation of DNA damage checkpoint +
                                                                        part-ofsignal transduction involved in DNA damage checkpoint +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle checkpoint
                                                is-aDNA integrity checkpoint
                                                        is-aDNA damage checkpoint
                                                                part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                                is-aG1 DNA damage checkpoint +
                                                                is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                        part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                        is-amitotic G2 DNA damage checkpoint +
                                                                        part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                                is-amitotic DNA damage checkpoint +
                                                                negatively-regulatesnegative regulation of DNA damage checkpoint
                                                                positively-regulatespositive regulation of DNA damage checkpoint
                                                                regulatesregulation of DNA damage checkpoint +
                                                                part-ofsignal transduction involved in DNA damage checkpoint +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular response to DNA damage stimulus
                                                is-aDNA damage checkpoint
                                                        part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                        is-aG1 DNA damage checkpoint +
                                                        is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                is-amitotic G2 DNA damage checkpoint +
                                                                part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                        is-amitotic DNA damage checkpoint +
                                                        negatively-regulatesnegative regulation of DNA damage checkpoint
                                                        positively-regulatespositive regulation of DNA damage checkpoint
                                                        regulatesregulation of DNA damage checkpoint +
                                                        part-ofsignal transduction involved in DNA damage checkpoint +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-acellular response to DNA damage stimulus
                                                is-aDNA damage checkpoint
                                                        part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                        is-aG1 DNA damage checkpoint +
                                                        is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                is-amitotic G2 DNA damage checkpoint +
                                                                part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                        is-amitotic DNA damage checkpoint +
                                                        negatively-regulatesnegative regulation of DNA damage checkpoint
                                                        positively-regulatespositive regulation of DNA damage checkpoint
                                                        regulatesregulation of DNA damage checkpoint +
                                                        part-ofsignal transduction involved in DNA damage checkpoint +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle checkpoint
                                                        is-aDNA integrity checkpoint
                                                                is-aDNA damage checkpoint
                                                                        part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                                        is-aG1 DNA damage checkpoint +
                                                                        is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                                part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                                is-amitotic G2 DNA damage checkpoint +
                                                                                part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                                        is-amitotic DNA damage checkpoint +
                                                                        negatively-regulatesnegative regulation of DNA damage checkpoint
                                                                        positively-regulatespositive regulation of DNA damage checkpoint
                                                                        regulatesregulation of DNA damage checkpoint +
                                                                        part-ofsignal transduction involved in DNA damage checkpoint +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle checkpoint
                                                is-aDNA integrity checkpoint
                                                        is-aDNA damage checkpoint
                                                                part-ofdetection of DNA damage stimulus involved in DNA damage checkpoint +
                                                                is-aG1 DNA damage checkpoint +
                                                                is-aG2 DNA damage checkpoint [GO:0031572] (32 genes, 33 annotations)
                                                                        part-ofdetection of DNA damage stimulus involved in G2 DNA damage checkpoint +
                                                                        is-amitotic G2 DNA damage checkpoint +
                                                                        part-ofsignal transduction involved in G2 DNA damage checkpoint +
                                                                is-amitotic DNA damage checkpoint +
                                                                negatively-regulatesnegative regulation of DNA damage checkpoint
                                                                positively-regulatespositive regulation of DNA damage checkpoint
                                                                regulatesregulation of DNA damage checkpoint +
                                                                part-ofsignal transduction involved in DNA damage checkpoint +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory