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Gene Ontology Browser
Term Detail
GO term:cullin-RING ubiquitin ligase complex
Synonym: CRL complex
Synonym: cullin complex
Synonym: cullin-RING ligase
GO id:GO:0031461
Definition:Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aubiquitin ligase complex
                                                        is-aBRE1 E3 ubiquitin ligase complex
                                                        is-aBre1-Rad6 ubiquitin ligase complex
                                                        is-acullin-RING ubiquitin ligase complex [GO:0031461] (100 genes, 136 annotations)
                                                                is-aanaphase-promoting complex
                                                                is-aCul2-RING ubiquitin ligase complex
                                                                is-aCul3-RING ubiquitin ligase complex
                                                                is-aCul4-RING E3 ubiquitin ligase complex +
                                                                is-aCul5-RING ubiquitin ligase complex
                                                                is-aCul7-RING ubiquitin ligase complex
                                                                is-aCul8-RING ubiquitin ligase complex
                                                                is-aSCF ubiquitin ligase complex +
                                                        is-acytoplasmic ubiquitin ligase complex +
                                                        is-aFused-Smurf ubiquitin ligase complex
                                                        is-aHULC complex
                                                        is-aLUBAC complex
                                                        is-aMUB1-RAD6-UBR2 ubiquitin ligase complex
                                                        is-anuclear ubiquitin ligase complex +
                                                        is-aParkin-FBXW7-Cul1 ubiquitin ligase complex
                                                        is-aRad6-Rad18 complex
                                                        is-aRAD6-UBR2 ubiquitin ligase complex
                                                        is-aRSP5-BUL ubiquitin ligase complex
                                                        is-aUBR1-RAD6 ubiquitin ligase complex


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aubiquitin ligase complex
                                                is-aBRE1 E3 ubiquitin ligase complex
                                                is-aBre1-Rad6 ubiquitin ligase complex
                                                is-acullin-RING ubiquitin ligase complex [GO:0031461] (100 genes, 136 annotations)
                                                        is-aanaphase-promoting complex
                                                        is-aCul2-RING ubiquitin ligase complex
                                                        is-aCul3-RING ubiquitin ligase complex
                                                        is-aCul4-RING E3 ubiquitin ligase complex +
                                                        is-aCul5-RING ubiquitin ligase complex
                                                        is-aCul7-RING ubiquitin ligase complex
                                                        is-aCul8-RING ubiquitin ligase complex
                                                        is-aSCF ubiquitin ligase complex +
                                                is-acytoplasmic ubiquitin ligase complex +
                                                is-aFused-Smurf ubiquitin ligase complex
                                                is-aHULC complex
                                                is-aLUBAC complex
                                                is-aMUB1-RAD6-UBR2 ubiquitin ligase complex
                                                is-anuclear ubiquitin ligase complex +
                                                is-aParkin-FBXW7-Cul1 ubiquitin ligase complex
                                                is-aRad6-Rad18 complex
                                                is-aRAD6-UBR2 ubiquitin ligase complex
                                                is-aRSP5-BUL ubiquitin ligase complex
                                                is-aUBR1-RAD6 ubiquitin ligase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aubiquitin ligase complex
                                                is-aBRE1 E3 ubiquitin ligase complex
                                                is-aBre1-Rad6 ubiquitin ligase complex
                                                is-acullin-RING ubiquitin ligase complex [GO:0031461] (100 genes, 136 annotations)
                                                        is-aanaphase-promoting complex
                                                        is-aCul2-RING ubiquitin ligase complex
                                                        is-aCul3-RING ubiquitin ligase complex
                                                        is-aCul4-RING E3 ubiquitin ligase complex +
                                                        is-aCul5-RING ubiquitin ligase complex
                                                        is-aCul7-RING ubiquitin ligase complex
                                                        is-aCul8-RING ubiquitin ligase complex
                                                        is-aSCF ubiquitin ligase complex +
                                                is-acytoplasmic ubiquitin ligase complex +
                                                is-aFused-Smurf ubiquitin ligase complex
                                                is-aHULC complex
                                                is-aLUBAC complex
                                                is-aMUB1-RAD6-UBR2 ubiquitin ligase complex
                                                is-anuclear ubiquitin ligase complex +
                                                is-aParkin-FBXW7-Cul1 ubiquitin ligase complex
                                                is-aRad6-Rad18 complex
                                                is-aRAD6-UBR2 ubiquitin ligase complex
                                                is-aRSP5-BUL ubiquitin ligase complex
                                                is-aUBR1-RAD6 ubiquitin ligase complex


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aubiquitin ligase complex
                                        is-aBRE1 E3 ubiquitin ligase complex
                                        is-aBre1-Rad6 ubiquitin ligase complex
                                        is-acullin-RING ubiquitin ligase complex [GO:0031461] (100 genes, 136 annotations)
                                                is-aanaphase-promoting complex
                                                is-aCul2-RING ubiquitin ligase complex
                                                is-aCul3-RING ubiquitin ligase complex
                                                is-aCul4-RING E3 ubiquitin ligase complex +
                                                is-aCul5-RING ubiquitin ligase complex
                                                is-aCul7-RING ubiquitin ligase complex
                                                is-aCul8-RING ubiquitin ligase complex
                                                is-aSCF ubiquitin ligase complex +
                                        is-acytoplasmic ubiquitin ligase complex +
                                        is-aFused-Smurf ubiquitin ligase complex
                                        is-aHULC complex
                                        is-aLUBAC complex
                                        is-aMUB1-RAD6-UBR2 ubiquitin ligase complex
                                        is-anuclear ubiquitin ligase complex +
                                        is-aParkin-FBXW7-Cul1 ubiquitin ligase complex
                                        is-aRad6-Rad18 complex
                                        is-aRAD6-UBR2 ubiquitin ligase complex
                                        is-aRSP5-BUL ubiquitin ligase complex
                                        is-aUBR1-RAD6 ubiquitin ligase complex


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-atransferase complex
                                                is-aubiquitin ligase complex
                                                        is-aBRE1 E3 ubiquitin ligase complex
                                                        is-aBre1-Rad6 ubiquitin ligase complex
                                                        is-acullin-RING ubiquitin ligase complex [GO:0031461] (100 genes, 136 annotations)
                                                                is-aanaphase-promoting complex
                                                                is-aCul2-RING ubiquitin ligase complex
                                                                is-aCul3-RING ubiquitin ligase complex
                                                                is-aCul4-RING E3 ubiquitin ligase complex +
                                                                is-aCul5-RING ubiquitin ligase complex
                                                                is-aCul7-RING ubiquitin ligase complex
                                                                is-aCul8-RING ubiquitin ligase complex
                                                                is-aSCF ubiquitin ligase complex +
                                                        is-acytoplasmic ubiquitin ligase complex +
                                                        is-aFused-Smurf ubiquitin ligase complex
                                                        is-aHULC complex
                                                        is-aLUBAC complex
                                                        is-aMUB1-RAD6-UBR2 ubiquitin ligase complex
                                                        is-anuclear ubiquitin ligase complex +
                                                        is-aParkin-FBXW7-Cul1 ubiquitin ligase complex
                                                        is-aRad6-Rad18 complex
                                                        is-aRAD6-UBR2 ubiquitin ligase complex
                                                        is-aRSP5-BUL ubiquitin ligase complex
                                                        is-aUBR1-RAD6 ubiquitin ligase complex


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-aubiquitin ligase complex
                                                is-aBRE1 E3 ubiquitin ligase complex
                                                is-aBre1-Rad6 ubiquitin ligase complex
                                                is-acullin-RING ubiquitin ligase complex [GO:0031461] (100 genes, 136 annotations)
                                                        is-aanaphase-promoting complex
                                                        is-aCul2-RING ubiquitin ligase complex
                                                        is-aCul3-RING ubiquitin ligase complex
                                                        is-aCul4-RING E3 ubiquitin ligase complex +
                                                        is-aCul5-RING ubiquitin ligase complex
                                                        is-aCul7-RING ubiquitin ligase complex
                                                        is-aCul8-RING ubiquitin ligase complex
                                                        is-aSCF ubiquitin ligase complex +
                                                is-acytoplasmic ubiquitin ligase complex +
                                                is-aFused-Smurf ubiquitin ligase complex
                                                is-aHULC complex
                                                is-aLUBAC complex
                                                is-aMUB1-RAD6-UBR2 ubiquitin ligase complex
                                                is-anuclear ubiquitin ligase complex +
                                                is-aParkin-FBXW7-Cul1 ubiquitin ligase complex
                                                is-aRad6-Rad18 complex
                                                is-aRAD6-UBR2 ubiquitin ligase complex
                                                is-aRSP5-BUL ubiquitin ligase complex
                                                is-aUBR1-RAD6 ubiquitin ligase complex


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory