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Term Detail
GO term:intrinsic component of membrane
Synonym: intrinsic to membrane
GO id:GO:0031224
Definition:The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
CommentsNote that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aalpha-1,6-mannosyltransferase complex
                                is-aanchored component of membrane +
                                is-aannulate lamellae
                                is-aAP-type membrane coat adaptor complex +
                                is-aATG1 kinase complex
                                is-aATPase dependent transmembrane transport complex +
                                is-aBam protein complex
                                is-aCdc48p-Npl4p-Ufd1p AAA ATPase complex
                                is-achloroplast ATP synthase complex
                                is-achloroplast outer membrane translocon
                                is-achromosome segregation-directing complex
                                is-aclathrin complex
                                is-acoated pit +
                                is-acytochrome o ubiquinol oxidase complex
                                is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                                is-aDsc E3 ubiquitin ligase complex
                                is-aEGO complex
                                is-aendoplasmic reticulum membrane +
                                is-aendoplasmic reticulum palmitoyltransferase complex +
                                is-aendoplasmic reticulum Sec complex +
                                is-aendosomal scaffold complex
                                is-aER membrane protein complex
                                is-aER ubiquitin ligase complex +
                                is-aESCRT I complex
                                is-aESCRT II complex
                                is-aESCRT III complex
                                is-aextrinsic component of membrane +
                                is-afatty acid elongase complex
                                is-afully spanning plasma membrane
                                is-afumarate reductase complex +
                                is-aGPI-anchor transamidase complex
                                is-aHOPS complex +
                                is-ainner acrosomal membrane
                                is-aintegral component of membrane +
                                is-aintrinsic component of membrane [GO:0031224] (6017 genes, 7232 annotations)
                                        part-ofanchored component of membrane +
                                        part-ofintegral component of membrane +
                                        is-aintrinsic component of cell outer membrane +
                                        is-aintrinsic component of organelle membrane +
                                        is-aintrinsic component of plasma membrane +
                                        is-aintrinsic component of thylakoid membrane +
                                is-aion channel complex +
                                is-aleaflet of membrane bilayer
                                is-alipopolysaccharide receptor complex
                                is-amacrolide transmembrane transporter complex +
                                is-amembrane coat +
                                is-amembrane raft +
                                is-amembrane region +
                                is-ameprin A complex
                                is-aMHC class I peptide loading complex +
                                is-amitochondrial membrane part +
                                is-aNAD(P)H dehydrogenase complex (plastoquinone)
                                is-aNADH dehydrogenase complex +
                                is-aNem1-Spo7 phosphatase complex
                                is-anuclear membrane part +
                                is-anuclear outer membrane +
                                is-anuclear outer membrane-endoplasmic reticulum membrane network +
                                is-anuclear pore central transport channel
                                is-anuclear pore cytoplasmic filaments
                                is-anuclear pore inner ring
                                is-anuclear pore linkers
                                is-anuclear pore nuclear basket
                                is-anuclear pore outer ring
                                is-anuclear pore transmembrane ring
                                is-aoligosaccharyltransferase complex +
                                is-aorganelle membrane contact site +
                                is-aouter acrosomal membrane
                                is-aPAS complex
                                is-aphotosystem +
                                is-aphotosystem I antenna complex
                                is-aphotosystem I reaction center
                                is-aphotosystem II antenna complex
                                is-aphotosystem II oxygen evolving complex
                                is-aphotosystem II reaction center
                                is-aphycobilisome
                                is-aplasma membrane part +
                                is-apore complex +
                                is-apre-B cell receptor complex
                                is-aprospore membrane leading edge
                                is-aprospore membrane spindle pole body attachment site
                                is-aprotein C inhibitor-acrosin complex
                                is-aproton-transporting ATP synthase, catalytic core +
                                is-aproton-transporting ATP synthase, central stalk +
                                is-aproton-transporting ATP synthase, stator stalk +
                                is-aproton-transporting two-sector ATPase complex +
                                is-aproton-transporting two-sector ATPase complex, catalytic domain +
                                is-aproton-transporting two-sector ATPase complex, proton-transporting domain +
                                is-aPSII associated light-harvesting complex II, core complex
                                is-aPSII associated light-harvesting complex II, peripheral complex +
                                is-aPSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
                                is-aRagulator complex
                                is-arespiratory chain +
                                is-arespiratory chain complex II +
                                is-arespiratory chain complex III +
                                is-arespiratory chain complex IV +
                                is-aretromer complex +
                                is-aretromer complex, inner shell
                                is-aretromer complex, outer shell
                                is-aSec62/Sec63 complex
                                is-aside of membrane +
                                is-asignal peptidase complex
                                is-asignal recognition particle receptor complex
                                is-aSNARE complex +
                                is-asodium ion-transporting two-sector ATPase complex +
                                is-aSREBP-SCAP complex
                                is-aSREBP-SCAP-Insig complex
                                is-astarch utilization system complex
                                is-aSTING complex
                                is-asuccinate dehydrogenase complex +
                                is-aTAP complex
                                is-athylakoid light-harvesting complex +
                                is-aTic complex
                                is-aToc complex
                                is-atranslocon complex +
                                is-atransmembrane transporter complex +
                                is-aUDP-N-acetylglucosamine transferase complex
                                is-aVps55/Vps68 complex


Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aalpha-1,6-mannosyltransferase complex
                        is-aanchored component of membrane +
                        is-aannulate lamellae
                        is-aAP-type membrane coat adaptor complex +
                        is-aATG1 kinase complex
                        is-aATPase dependent transmembrane transport complex +
                        is-aBam protein complex
                        is-aCdc48p-Npl4p-Ufd1p AAA ATPase complex
                        is-achloroplast ATP synthase complex
                        is-achloroplast outer membrane translocon
                        is-achromosome segregation-directing complex
                        is-aclathrin complex
                        is-acoated pit +
                        is-acytochrome o ubiquinol oxidase complex
                        is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                        is-aDsc E3 ubiquitin ligase complex
                        is-aEGO complex
                        is-aendoplasmic reticulum membrane +
                        is-aendoplasmic reticulum palmitoyltransferase complex +
                        is-aendoplasmic reticulum Sec complex +
                        is-aendosomal scaffold complex
                        is-aER membrane protein complex
                        is-aER ubiquitin ligase complex +
                        is-aESCRT I complex
                        is-aESCRT II complex
                        is-aESCRT III complex
                        is-aextrinsic component of membrane +
                        is-afatty acid elongase complex
                        is-afully spanning plasma membrane
                        is-afumarate reductase complex +
                        is-aGPI-anchor transamidase complex
                        is-aHOPS complex +
                        is-ainner acrosomal membrane
                        is-aintegral component of membrane +
                        is-aintrinsic component of membrane [GO:0031224] (6017 genes, 7232 annotations)
                                part-ofanchored component of membrane +
                                part-ofintegral component of membrane +
                                is-aintrinsic component of cell outer membrane +
                                is-aintrinsic component of organelle membrane +
                                is-aintrinsic component of plasma membrane +
                                is-aintrinsic component of thylakoid membrane +
                        is-aion channel complex +
                        is-aleaflet of membrane bilayer
                        is-alipopolysaccharide receptor complex
                        is-amacrolide transmembrane transporter complex +
                        is-amembrane coat +
                        is-amembrane raft +
                        is-amembrane region +
                        is-ameprin A complex
                        is-aMHC class I peptide loading complex +
                        is-amitochondrial membrane part +
                        is-aNAD(P)H dehydrogenase complex (plastoquinone)
                        is-aNADH dehydrogenase complex +
                        is-aNem1-Spo7 phosphatase complex
                        is-anuclear membrane part +
                        is-anuclear outer membrane +
                        is-anuclear outer membrane-endoplasmic reticulum membrane network +
                        is-anuclear pore central transport channel
                        is-anuclear pore cytoplasmic filaments
                        is-anuclear pore inner ring
                        is-anuclear pore linkers
                        is-anuclear pore nuclear basket
                        is-anuclear pore outer ring
                        is-anuclear pore transmembrane ring
                        is-aoligosaccharyltransferase complex +
                        is-aorganelle membrane contact site +
                        is-aouter acrosomal membrane
                        is-aPAS complex
                        is-aphotosystem +
                        is-aphotosystem I antenna complex
                        is-aphotosystem I reaction center
                        is-aphotosystem II antenna complex
                        is-aphotosystem II oxygen evolving complex
                        is-aphotosystem II reaction center
                        is-aphycobilisome
                        is-aplasma membrane part +
                        is-apore complex +
                        is-apre-B cell receptor complex
                        is-aprospore membrane leading edge
                        is-aprospore membrane spindle pole body attachment site
                        is-aprotein C inhibitor-acrosin complex
                        is-aproton-transporting ATP synthase, catalytic core +
                        is-aproton-transporting ATP synthase, central stalk +
                        is-aproton-transporting ATP synthase, stator stalk +
                        is-aproton-transporting two-sector ATPase complex +
                        is-aproton-transporting two-sector ATPase complex, catalytic domain +
                        is-aproton-transporting two-sector ATPase complex, proton-transporting domain +
                        is-aPSII associated light-harvesting complex II, core complex
                        is-aPSII associated light-harvesting complex II, peripheral complex +
                        is-aPSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
                        is-aRagulator complex
                        is-arespiratory chain +
                        is-arespiratory chain complex II +
                        is-arespiratory chain complex III +
                        is-arespiratory chain complex IV +
                        is-aretromer complex +
                        is-aretromer complex, inner shell
                        is-aretromer complex, outer shell
                        is-aSec62/Sec63 complex
                        is-aside of membrane +
                        is-asignal peptidase complex
                        is-asignal recognition particle receptor complex
                        is-aSNARE complex +
                        is-asodium ion-transporting two-sector ATPase complex +
                        is-aSREBP-SCAP complex
                        is-aSREBP-SCAP-Insig complex
                        is-astarch utilization system complex
                        is-aSTING complex
                        is-asuccinate dehydrogenase complex +
                        is-aTAP complex
                        is-athylakoid light-harvesting complex +
                        is-aTic complex
                        is-aToc complex
                        is-atranslocon complex +
                        is-atransmembrane transporter complex +
                        is-aUDP-N-acetylglucosamine transferase complex
                        is-aVps55/Vps68 complex


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory