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Gene Ontology Browser
Term Detail
GO term:intrinsic component of membrane
Synonym: intrinsic to membrane
GO id:GO:0031224
Definition:The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
CommentsNote that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aendoplasmic reticulum membrane +
                                is-aextrinsic component of membrane +
                                is-aintrinsic component of membrane [GO:0031224] (5822 genes, 8300 annotations)
                                        is-aanchored component of membrane +
                                        is-aintegral component of membrane +
                                        is-aintrinsic component of cell outer membrane +
                                        is-aintrinsic component of organelle membrane +
                                        is-aintrinsic component of plasma membrane +
                                        is-aintrinsic component of thylakoid membrane +
                                is-aleaflet of membrane bilayer
                                is-amembrane protein complex +
                                is-amembrane region +
                                is-amitochondrial membrane part +
                                is-anuclear membrane part +
                                is-anuclear outer membrane +
                                is-aorganelle membrane contact site +
                                is-aplasma membrane part +
                                is-arespiratory chain +
                                is-aside of membrane +


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aendoplasmic reticulum membrane +
                        is-aextrinsic component of membrane +
                        is-aintrinsic component of membrane [GO:0031224] (5822 genes, 8300 annotations)
                                is-aanchored component of membrane +
                                is-aintegral component of membrane +
                                is-aintrinsic component of cell outer membrane +
                                is-aintrinsic component of organelle membrane +
                                is-aintrinsic component of plasma membrane +
                                is-aintrinsic component of thylakoid membrane +
                        is-aleaflet of membrane bilayer
                        is-amembrane protein complex +
                        is-amembrane region +
                        is-amitochondrial membrane part +
                        is-anuclear membrane part +
                        is-anuclear outer membrane +
                        is-aorganelle membrane contact site +
                        is-aplasma membrane part +
                        is-arespiratory chain +
                        is-aside of membrane +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory