About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:gene silencing
Synonym: long-term maintenance of gene inactivation
GO id:GO:0016458
Definition:Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.
CommentsNote that this process is the opposite of long-term maintenance of gene activation.
Number of paths to term: 20

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of metabolic process
                                                is-anegative regulation of macromolecule metabolic process
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-anegative regulation of metabolic process
                                                is-anegative regulation of macromolecule metabolic process
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-anegative regulation of macromolecule metabolic process
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-aregulation of gene expression
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-aactin cortical patch organization +
                                is-aactin filament-based process +
                                is-ablood microparticle formation +
                                is-acell activation +
                                is-acell adhesion +
                                is-acell adhesion molecule production +
                                is-acell aging +
                                is-acell communication +
                                is-acell competition in a multicellular organism
                                is-acell cycle +
                                is-acell cycle process +
                                is-acell death +
                                is-acell division +
                                is-acell growth +
                                is-acell junction organization +
                                is-acell projection organization +
                                is-acell recognition +
                                is-acell wall organization or biogenesis +
                                is-acellular component disassembly +
                                is-acellular component maintenance +
                                is-acellular component movement +
                                is-acellular developmental process +
                                is-acellular homeostasis +
                                is-acellular localization +
                                is-acellular membrane organization +
                                is-acellular pigmentation +
                                is-acellular potassium ion transport +
                                is-acellular response to stimulus +
                                is-achromosome number maintenance
                                is-achromosome segregation +
                                is-acontact inhibition +
                                is-acytoplasm organization +
                                is-adendritic spine organization +
                                is-aDNA packaging +
                                is-aensheathment of neurons +
                                is-aestablishment or maintenance of cell polarity +
                                is-aestablishment or maintenance of cell type involved in phenotypic switching
                                is-aexecution phase of apoptosis +
                                is-aexternal encapsulating structure organization +
                                is-aextracellular structure organization +
                                is-afibril organization +
                                is-aG0 to G1 transition +
                                is-aG1 to G0 transition +
                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                        is-achromatin silencing +
                                        is-agene silencing by RNA +
                                        is-agene silencing involved in chronological cell aging
                                        negatively-regulatesnegative regulation of gene silencing +
                                        is-aposttranscriptional gene silencing +
                                        regulatesregulation of gene silencing +
                                is-ageneration of a signal involved in cell-cell signaling +
                                is-aintercellular transport +
                                is-aintermediate filament-based process +
                                is-alight absorption +
                                is-amaintenance of blood-brain barrier
                                is-amaintenance of location in cell +
                                is-amembrane docking +
                                is-amicrotubule organizing center attachment site organization
                                is-amicrotubule-based process +
                                is-anegative regulation of cellular component organization +
                                is-anucleoid organization +
                                is-aorganelle organization +
                                is-aperiplasmic space organization
                                is-aphotoreceptor cell outer segment organization
                                is-aplasmid maintenance +
                                is-aplastoglobule organization
                                is-aregulation of cellular component size +
                                is-areversion of cell type to default state involved in phenotypic switching
                                is-asecretion by cell +
                                is-asignal maturation +
                                is-asignal release +
                                is-asingle-celled organism vegetative growth phase +
                                is-astomatal movement +
                                is-asynapse organization +
                                is-asyncytium formation +
                                is-aterminal button organization +
                                is-atranslational initiation +
                                is-atransmembrane transport +
                                is-atransposition +
                                is-avesicle targeting +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        negatively-regulatesnegative regulation of metabolic process
                                is-anegative regulation of macromolecule metabolic process
                                        is-anegative regulation of gene expression
                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                        is-achromatin silencing +
                                                        is-agene silencing by RNA +
                                                        is-agene silencing involved in chronological cell aging
                                                        negatively-regulatesnegative regulation of gene silencing +
                                                        is-aposttranscriptional gene silencing +
                                                        regulatesregulation of gene silencing +
                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                is-anegative regulation of gene expression, epigenetic +
                                                is-anegative regulation of histone gene expression
                                                is-anegative regulation of rhodopsin gene expression
                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                negatively-regulatesnegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                regulatesregulation of gene expression
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        negatively-regulatesnegative regulation of macromolecule metabolic process
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-anegative regulation of macromolecule metabolic process
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-aregulation of gene expression
                                                        is-anegative regulation of gene expression
                                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                        is-achromatin silencing +
                                                                        is-agene silencing by RNA +
                                                                        is-agene silencing involved in chronological cell aging
                                                                        negatively-regulatesnegative regulation of gene silencing +
                                                                        is-aposttranscriptional gene silencing +
                                                                        regulatesregulation of gene silencing +
                                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                                is-anegative regulation of gene expression, epigenetic +
                                                                is-anegative regulation of histone gene expression
                                                                is-anegative regulation of rhodopsin gene expression
                                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-anegative regulation of metabolic process
                                        is-anegative regulation of macromolecule metabolic process
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-anegative regulation of macromolecule metabolic process
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of gene expression
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                negatively-regulatesnegative regulation of biological process
                        is-anegative regulation of metabolic process
                                is-anegative regulation of macromolecule metabolic process
                                        is-anegative regulation of gene expression
                                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                        is-achromatin silencing +
                                                        is-agene silencing by RNA +
                                                        is-agene silencing involved in chronological cell aging
                                                        negatively-regulatesnegative regulation of gene silencing +
                                                        is-aposttranscriptional gene silencing +
                                                        regulatesregulation of gene silencing +
                                                is-anegative regulation of gene expression involved in extracellular matrix organization
                                                is-anegative regulation of gene expression, epigenetic +
                                                is-anegative regulation of histone gene expression
                                                is-anegative regulation of rhodopsin gene expression
                                                is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-anegative regulation of biological process
                                is-anegative regulation of metabolic process
                                        is-anegative regulation of macromolecule metabolic process
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-anegative regulation of metabolic process
                                        is-anegative regulation of macromolecule metabolic process
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-anegative regulation of macromolecule metabolic process
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of gene expression
                                                is-anegative regulation of gene expression
                                                        is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                                                is-achromatin silencing +
                                                                is-agene silencing by RNA +
                                                                is-agene silencing involved in chronological cell aging
                                                                negatively-regulatesnegative regulation of gene silencing +
                                                                is-aposttranscriptional gene silencing +
                                                                regulatesregulation of gene silencing +
                                                        is-anegative regulation of gene expression involved in extracellular matrix organization
                                                        is-anegative regulation of gene expression, epigenetic +
                                                        is-anegative regulation of histone gene expression
                                                        is-anegative regulation of rhodopsin gene expression
                                                        is-anegative regulation of transcription, DNA-dependent +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-aactin cortical patch organization +
                                is-aactin filament-based process +
                                is-ablood microparticle formation +
                                is-acell activation +
                                is-acell adhesion +
                                is-acell adhesion molecule production +
                                is-acell aging +
                                is-acell communication +
                                is-acell competition in a multicellular organism
                                is-acell cycle +
                                is-acell cycle process +
                                is-acell death +
                                is-acell division +
                                is-acell growth +
                                is-acell junction organization +
                                is-acell projection organization +
                                is-acell recognition +
                                is-acell wall organization or biogenesis +
                                is-acellular component disassembly +
                                is-acellular component maintenance +
                                is-acellular component movement +
                                is-acellular developmental process +
                                is-acellular homeostasis +
                                is-acellular localization +
                                is-acellular membrane organization +
                                is-acellular pigmentation +
                                is-acellular potassium ion transport +
                                is-acellular response to stimulus +
                                is-achromosome number maintenance
                                is-achromosome segregation +
                                is-acontact inhibition +
                                is-acytoplasm organization +
                                is-adendritic spine organization +
                                is-aDNA packaging +
                                is-aensheathment of neurons +
                                is-aestablishment or maintenance of cell polarity +
                                is-aestablishment or maintenance of cell type involved in phenotypic switching
                                is-aexecution phase of apoptosis +
                                is-aexternal encapsulating structure organization +
                                is-aextracellular structure organization +
                                is-afibril organization +
                                is-aG0 to G1 transition +
                                is-aG1 to G0 transition +
                                is-agene silencing [GO:0016458] (116 genes, 173 annotations)
                                        is-achromatin silencing +
                                        is-agene silencing by RNA +
                                        is-agene silencing involved in chronological cell aging
                                        negatively-regulatesnegative regulation of gene silencing +
                                        is-aposttranscriptional gene silencing +
                                        regulatesregulation of gene silencing +
                                is-ageneration of a signal involved in cell-cell signaling +
                                is-aintercellular transport +
                                is-aintermediate filament-based process +
                                is-alight absorption +
                                is-amaintenance of blood-brain barrier
                                is-amaintenance of location in cell +
                                is-amembrane docking +
                                is-amicrotubule organizing center attachment site organization
                                is-amicrotubule-based process +
                                is-anegative regulation of cellular component organization +
                                is-anucleoid organization +
                                is-aorganelle organization +
                                is-aperiplasmic space organization
                                is-aphotoreceptor cell outer segment organization
                                is-aplasmid maintenance +
                                is-aplastoglobule organization
                                is-aregulation of cellular component size +
                                is-areversion of cell type to default state involved in phenotypic switching
                                is-asecretion by cell +
                                is-asignal maturation +
                                is-asignal release +
                                is-asingle-celled organism vegetative growth phase +
                                is-astomatal movement +
                                is-asynapse organization +
                                is-asyncytium formation +
                                is-aterminal button organization +
                                is-atranslational initiation +
                                is-atransmembrane transport +
                                is-atransposition +
                                is-avesicle targeting +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2013
MGI 5.14
The Jackson Laboratory