| GO term: | catechol O-methyltransferase activity |
| Synonym: | catecholamine O-methyltransferase activity |
| Synonym: | catechol methyltransferase activity |
| Synonym: | COMT I |
| Synonym: | COMT II |
| Synonym: | MB-COMT (membrane-bound form of catechol-O-methyltransferase) |
| Synonym: | S-adenosyl-L-methionine:catechol O-methyltransferase activity |
| Synonym: | S-COMT (soluble form of catechol-O-methyltransferase) |
| GO id: | GO:0016206 |
| Definition: | Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functioncatalytic activitytransferase activitytransferase activity, transferring one-carbon groupsmethyltransferase activityO-methyltransferase activity(iso)eugenol O-methyltransferase activity2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity2-phytyl-1,4-naphthoquinone methyltransferase activity3-demethylubiquinone-10 3-O-methyltransferase activity3-demethylubiquinone-9 3-O-methyltransferase activityacetylserotonin O-methyltransferase activitycaffeate O-methyltransferase activitycaffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activitycaffeoyl-CoA O-methyltransferase activitycarboxyl-O-methyltransferase activity +catechol O-methyltransferase activity [GO:0016206] (2 genes, 4 annotations)demethylsterigmatocystin 6-O-methyltransferase activityfarnesoic acid O-methyltransferase activityisoflavone 7-O-methyltransferase activityisoliquiritigenin 2'-O-methyltransferase activitykaempferol 4'-O-methyltransferase activitylaricitrin 5'-O-methyltransferase activitymagnesium protoporphyrin IX methyltransferase activitymRNA (nucleoside-2'-O-)-methyltransferase activitymyricetin 3'-O-methyltransferase activityrRNA (adenosine-2'-O-)-methyltransferase activityrRNA (cytosine-2'-O-)-methyltransferase activityrRNA (guanosine-2'-O-)-methyltransferase activityrRNA (uridine-2'-O-)-methyltransferase activityS-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activitysmall RNA 2'-O-methyltransferasesterigmatocystin 7-O-methyltransferase activitytocopherol O-methyltransferase activitytricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activitytrihydroxyferuloyl spermidine O-methyltransferase activitytrihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activityvitexin 2''-O-rhamnoside 7-O-methyltransferase activitymolecular_functioncatalytic activitytransferase activitytransferase activity, transferring one-carbon groupsmethyltransferase activityS-adenosylmethionine-dependent methyltransferase activity(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity(RS)-norcoclaurine 6-O-methyltransferase activity(S)-coclaurine-N-methyltransferase activity(S)-scoulerine 9-O-methyltransferase activity(S)-tetrahydroprotoberberine N-methyltransferase activity10-hydroxydihydrosanguinarine 10-O-methyltransferase activity11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity12-hydroxydihydrochelirubine 12-O-methyltransferase activity16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity24-methylenesterol C-methyltransferase activity3'-demethylstaurosporine O-methyltransferase activity3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity3,7-dimethylquercitin 4'-O-methyltransferase activity3-demethylubiquinone-10 3-O-methyltransferase activity3-demethylubiquinone-9 3-O-methyltransferase activity3-hydroxyanthranilate 4-C-methyltransferase activity3-methylquercitin 7-O-methyltransferase activity5-hydroxyfuranocoumarin 5-O-methyltransferase activity6-hydroxymellein O-methyltransferase activity6-O-methylnorlaudanosoline 5'-O-methyltransferase activity8-hydroxyfuranocoumarin 8-O-methyltransferase activity8-hydroxyquercitin 8-O-methyltransferase activity[cytochrome c]-methionine S-methyltransferase activity[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activityacetylserotonin O-methyltransferase activityamine N-methyltransferase activityanthranilate N-methyltransferase activityapigenin 4'-O-methyltransferase activityarginine N-methyltransferase activity +arsenite methyltransferase activitycaffeoyl-CoA O-methyltransferase activitycarnosine N-methyltransferase activitycatechol O-methyltransferase activity [GO:0016206] (2 genes, 4 annotations)chlorophenol O-methyltransferase activitycolumbamine O-methyltransferase activitycycloartenol 24-C-methyltransferase activitycyclopropane-fatty-acyl-phospholipid synthase activitydemethylmacrocin O-methyltransferase activitydimethylglycine N-methyltransferase activitydimethylhistidine N-methyltransferase activitydiphthine synthase activityDNA (cytosine-5-)-methyltransferase activity +farnesoic acid O-methyltransferase activityfatty acid O-methyltransferase activityglucuronoxylan 4-O-methyltransferase activityglycine N-methyltransferase activityguanidinoacetate N-methyltransferase activityhistamine N-methyltransferase activityhistidine N-methyltransferase activityhomocysteine S-methyltransferase activityindolepyruvate C-methyltransferase activityinositol 1-methyltransferase activityinositol 3-methyltransferase activityinositol 4-methyltransferase activityiodophenol O-methyltransferase activityisobutyraldoxime O-methyltransferase activityisoflavone 4'-O-methyltransferase activityisoflavone 7-O-methyltransferase activityisoliquiritigenin 2'-O-methyltransferase activityisoorientin 3'-O-methyltransferase activityjasmonate O-methyltransferase activitykaempferol 4'-O-methyltransferase activitylaricitrin 5'-O-methyltransferase activitylicodione 2'-O-methyltransferase activitylipid A phosphate methyltransferase activityloganate O-methyltransferase activityluteolin O-methyltransferase activitylysine N-methyltransferase activity +macrocin O-methyltransferase activitymagnesium protoporphyrin IX methyltransferase activitymethionine S-methyltransferase activitymethylarsonite methyltransferase activitymethylene-fatty-acyl-phospholipid synthase activitymethylhistidine N-methyltransferase activitymethylquercetagetin 6-O-methyltransferase activitymRNA methyltransferase activity +myricetin 3'-O-methyltransferase activityN-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activitynicotinamide N-methyltransferase activitynicotinate N-methyltransferase activityO-demethylpuromycin O-methyltransferase activitypeptidyl-arginine C-methyltransferase activityphenol O-methyltransferase activityphenylethanolamine N-methyltransferase activityphosphatidyl-N-dimethylethanolamine N-methyltransferase activityphosphatidyl-N-methylethanolamine N-methyltransferase activityphosphatidylethanolamine N-methyltransferase activityphosphoethanolamine N-methyltransferase activityphosphomethylethanolamine N-methyltransferase activitypolyprenyldihydroxybenzoate methyltransferase activity +polysaccharide O-methyltransferase activityprecorrin-2 C20-methyltransferase activityprecorrin-3B C17-methyltransferase activityprecorrin-4 C11-methyltransferase activityprecorrin-6Y C5,15-methyltransferase (decarboxylating) activityprotein C-terminal leucine carboxyl O-methyltransferase activityprotein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activityprotein-glutamate O-methyltransferase activityprotein-glutamine N-methyltransferase activityprotein-histidine N-methyltransferase activityprotein-L-isoaspartate (D-aspartate) O-methyltransferase activityputrescine N-methyltransferase activitypyridine N-methyltransferase activityquercetin 3-O-methyltransferase activityrRNA methyltransferase activity +S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activitysarcosine N-methyltransferase activitysite-specific DNA-methyltransferase (adenine-specific) activitysite-specific DNA-methyltransferase (cytosine-N4-specific) activitysterol 24-C-methyltransferase activitytellurite methyltransferase activitytetrahydrocolumbamine 2-O-methyltransferase activitythioether S-methyltransferase activitythiol S-methyltransferase activitythiopurine S-methyltransferase activitytrans-aconitate 2-methyltransferase activitytrans-aconitate 3-methyltransferase activitytRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activitytRNA (adenine) methyltransferase activity +tRNA (cytosine) methyltransferase activity +tRNA (guanine) methyltransferase activity +tryptophan 2-C-methyltransferase activitytyramine N-methyltransferase activityuroporphyrin-III C-methyltransferase activityvitexin 2''-O-rhamnoside 7-O-methyltransferase activityMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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