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Gene Ontology Browser
Term Detail
GO term:catechol O-methyltransferase activity
Synonym: catecholamine O-methyltransferase activity
Synonym: catechol methyltransferase activity
Synonym: COMT I
Synonym: COMT II
Synonym: MB-COMT (membrane-bound form of catechol-O-methyltransferase)
Synonym: S-adenosyl-L-methionine:catechol O-methyltransferase activity
Synonym: S-COMT (soluble form of catechol-O-methyltransferase)
GO id:GO:0016206
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring one-carbon groups
                                        is-amethyltransferase activity
                                                is-aO-methyltransferase activity
                                                        is-a(iso)eugenol O-methyltransferase activity
                                                        is-a2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity
                                                        is-a2-phytyl-1,4-naphthoquinone methyltransferase activity
                                                        is-a3-demethylubiquinone-n 3-O-methyltransferase activity +
                                                        is-aacetylserotonin O-methyltransferase activity
                                                        is-acaffeate O-methyltransferase activity
                                                        is-acaffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity
                                                        is-acaffeoyl-CoA O-methyltransferase activity
                                                        is-acarboxyl-O-methyltransferase activity +
                                                        is-acatechol O-methyltransferase activity [GO:0016206] (2 genes, 4 annotations)
                                                        is-ademethylsterigmatocystin 6-O-methyltransferase activity
                                                        is-afarnesoic acid O-methyltransferase activity
                                                        is-aisoflavone 7-O-methyltransferase activity
                                                        is-aisoliquiritigenin 2'-O-methyltransferase activity
                                                        is-akaempferol 4'-O-methyltransferase activity
                                                        is-alaricitrin 5'-O-methyltransferase activity
                                                        is-amagnesium protoporphyrin IX methyltransferase activity
                                                        is-amRNA (nucleoside-2'-O-)-methyltransferase activity
                                                        is-amyricetin 3'-O-methyltransferase activity
                                                        is-arRNA (adenosine-2'-O-)-methyltransferase activity
                                                        is-arRNA (cytosine-2'-O-)-methyltransferase activity
                                                        is-arRNA (guanosine-2'-O-)-methyltransferase activity
                                                        is-arRNA (uridine-2'-O-)-methyltransferase activity
                                                        is-aS-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity
                                                        is-asmall RNA 2'-O-methyltransferase
                                                        is-asterigmatocystin 7-O-methyltransferase activity
                                                        is-atocopherol O-methyltransferase activity
                                                        is-atricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
                                                        is-atrihydroxyferuloyl spermidine O-methyltransferase activity
                                                        is-atrihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
                                                        is-avitexin 2''-O-rhamnoside 7-O-methyltransferase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring one-carbon groups
                                        is-amethyltransferase activity
                                                is-aS-adenosylmethionine-dependent methyltransferase activity
                                                        is-a(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
                                                        is-a(RS)-norcoclaurine 6-O-methyltransferase activity
                                                        is-a(S)-coclaurine-N-methyltransferase activity
                                                        is-a(S)-scoulerine 9-O-methyltransferase activity
                                                        is-a(S)-tetrahydroprotoberberine N-methyltransferase activity
                                                        is-a10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
                                                        is-a11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
                                                        is-a12-hydroxydihydrochelirubine 12-O-methyltransferase activity
                                                        is-a16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
                                                        is-a2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
                                                        is-a2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
                                                        is-a24-methylenesterol C-methyltransferase activity
                                                        is-a3'-demethylstaurosporine O-methyltransferase activity
                                                        is-a3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
                                                        is-a3,7-dimethylquercitin 4'-O-methyltransferase activity
                                                        is-a3-demethylubiquinone-10 3-O-methyltransferase activity
                                                        is-a3-demethylubiquinone-9 3-O-methyltransferase activity
                                                        is-a3-hydroxyanthranilate 4-C-methyltransferase activity
                                                        is-a3-methylquercitin 7-O-methyltransferase activity
                                                        is-a5-hydroxyfuranocoumarin 5-O-methyltransferase activity
                                                        is-a6-hydroxymellein O-methyltransferase activity
                                                        is-a6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
                                                        is-a8-hydroxyfuranocoumarin 8-O-methyltransferase activity
                                                        is-a8-hydroxyquercitin 8-O-methyltransferase activity
                                                        is-a[cytochrome c]-methionine S-methyltransferase activity
                                                        is-a[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
                                                        is-aacetylserotonin O-methyltransferase activity
                                                        is-aamine N-methyltransferase activity
                                                        is-aanthranilate N-methyltransferase activity
                                                        is-aapigenin 4'-O-methyltransferase activity
                                                        is-aarginine N-methyltransferase activity +
                                                        is-aarsenite methyltransferase activity
                                                        is-acaffeoyl-CoA O-methyltransferase activity
                                                        is-acarnosine N-methyltransferase activity
                                                        is-acatechol O-methyltransferase activity [GO:0016206] (2 genes, 4 annotations)
                                                        is-achlorophenol O-methyltransferase activity
                                                        is-acolumbamine O-methyltransferase activity
                                                        is-acycloartenol 24-C-methyltransferase activity
                                                        is-acyclopropane-fatty-acyl-phospholipid synthase activity
                                                        is-ademethylmacrocin O-methyltransferase activity
                                                        is-adimethylglycine N-methyltransferase activity
                                                        is-adimethylhistidine N-methyltransferase activity
                                                        is-adiphthine synthase activity
                                                        is-aDNA (cytosine-5-)-methyltransferase activity +
                                                        is-afarnesoic acid O-methyltransferase activity
                                                        is-afatty acid O-methyltransferase activity
                                                        is-aglucuronoxylan 4-O-methyltransferase activity
                                                        is-aglycine N-methyltransferase activity
                                                        is-aguanidinoacetate N-methyltransferase activity
                                                        is-ahistamine N-methyltransferase activity
                                                        is-ahistidine N-methyltransferase activity
                                                        is-aindolepyruvate C-methyltransferase activity
                                                        is-ainositol 1-methyltransferase activity
                                                        is-ainositol 3-methyltransferase activity
                                                        is-ainositol 4-methyltransferase activity
                                                        is-aiodophenol O-methyltransferase activity
                                                        is-aisobutyraldoxime O-methyltransferase activity
                                                        is-aisoflavone 4'-O-methyltransferase activity
                                                        is-aisoflavone 7-O-methyltransferase activity
                                                        is-aisoliquiritigenin 2'-O-methyltransferase activity
                                                        is-aisoorientin 3'-O-methyltransferase activity
                                                        is-ajasmonate O-methyltransferase activity
                                                        is-akaempferol 4'-O-methyltransferase activity
                                                        is-alaricitrin 5'-O-methyltransferase activity
                                                        is-alicodione 2'-O-methyltransferase activity
                                                        is-alipid A phosphate methyltransferase activity
                                                        is-aloganate O-methyltransferase activity
                                                        is-aluteolin O-methyltransferase activity
                                                        is-alysine N-methyltransferase activity +
                                                        is-amacrocin O-methyltransferase activity
                                                        is-amagnesium protoporphyrin IX methyltransferase activity
                                                        is-amethionine S-methyltransferase activity
                                                        is-amethylarsonite methyltransferase activity
                                                        is-amethylene-fatty-acyl-phospholipid synthase activity
                                                        is-amethylhistidine N-methyltransferase activity
                                                        is-amethylquercetagetin 6-O-methyltransferase activity
                                                        is-amRNA methyltransferase activity +
                                                        is-amyricetin 3'-O-methyltransferase activity
                                                        is-aN-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
                                                        is-anicotinamide N-methyltransferase activity
                                                        is-anicotinate N-methyltransferase activity
                                                        is-aO-demethylpuromycin O-methyltransferase activity
                                                        is-apeptidyl-arginine C-methyltransferase activity
                                                        is-aphenol O-methyltransferase activity
                                                        is-aphenylethanolamine N-methyltransferase activity
                                                        is-aphosphatidyl-N-dimethylethanolamine N-methyltransferase activity
                                                        is-aphosphatidyl-N-methylethanolamine N-methyltransferase activity
                                                        is-aphosphatidylethanolamine N-methyltransferase activity
                                                        is-aphosphoethanolamine N-methyltransferase activity
                                                        is-aphosphomethylethanolamine N-methyltransferase activity
                                                        is-apolyprenyldihydroxybenzoate methyltransferase activity +
                                                        is-apolysaccharide O-methyltransferase activity
                                                        is-aprecorrin-2 C20-methyltransferase activity
                                                        is-aprecorrin-3B C17-methyltransferase activity
                                                        is-aprecorrin-4 C11-methyltransferase activity
                                                        is-aprecorrin-6Y C5,15-methyltransferase (decarboxylating) activity
                                                        is-aprotein C-terminal leucine carboxyl O-methyltransferase activity
                                                        is-aprotein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
                                                        is-aprotein-glutamate O-methyltransferase activity
                                                        is-aprotein-glutamine N-methyltransferase activity +
                                                        is-aprotein-histidine N-methyltransferase activity
                                                        is-aprotein-L-isoaspartate (D-aspartate) O-methyltransferase activity
                                                        is-aputrescine N-methyltransferase activity
                                                        is-apyridine N-methyltransferase activity
                                                        is-aquercetin 3-O-methyltransferase activity
                                                        is-aRNA 5'-methyltransferase activity
                                                        is-arRNA methyltransferase activity +
                                                        is-aS-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
                                                        is-aS-adenosylmethionine-homocysteine S-methyltransferase activity
                                                        is-asarcosine N-methyltransferase activity
                                                        is-asite-specific DNA-methyltransferase (adenine-specific) activity
                                                        is-asite-specific DNA-methyltransferase (cytosine-N4-specific) activity
                                                        is-asterol 24-C-methyltransferase activity
                                                        is-atellurite methyltransferase activity
                                                        is-atetrahydrocolumbamine 2-O-methyltransferase activity
                                                        is-athioether S-methyltransferase activity
                                                        is-athiol S-methyltransferase activity
                                                        is-athiopurine S-methyltransferase activity
                                                        is-atrans-aconitate 2-methyltransferase activity
                                                        is-atrans-aconitate 3-methyltransferase activity
                                                        is-atRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
                                                        is-atRNA (adenine) methyltransferase activity +
                                                        is-atRNA (cytosine) methyltransferase activity +
                                                        is-atRNA (guanine) methyltransferase activity +
                                                        is-atryptophan 2-C-methyltransferase activity
                                                        is-atyramine N-methyltransferase activity
                                                        is-auroporphyrin-III C-methyltransferase activity
                                                        is-avitexin 2''-O-rhamnoside 7-O-methyltransferase activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory