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Gene Ontology Browser
Term Detail
GO term:RNA modification
Synonym: RNA editing
GO id:GO:0009451
Definition:The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.
CommentsThe term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing.
Number of paths to term: 14

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular macromolecule metabolic process
                                        is-aRNA metabolic process
                                                is-alagging strand elongation +
                                                is-aleading strand elongation
                                                is-amitochondrial RNA metabolic process +
                                                is-amRNA metabolic process +
                                                is-ancRNA metabolic process +
                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                positively-regulatespositive regulation of RNA metabolic process +
                                                regulatesregulation of RNA metabolic process +
                                                is-aRNA biosynthetic process +
                                                is-aRNA catabolic process +
                                                is-aRNA exon ligation +
                                                is-aRNA folding
                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                        is-abase conversion or substitution editing +
                                                        is-achloroplast RNA modification +
                                                        is-amitochondrial RNA modification +
                                                        is-amRNA modification +
                                                        is-aoxidative RNA demethylation +
                                                        is-apseudouridine synthesis +
                                                        is-aRNA methylation +
                                                        is-aRNA nucleotide deletion +
                                                        is-aRNA nucleotide insertion +
                                                        is-arRNA modification +
                                                        is-asnRNA modification +
                                                        is-atRNA modification +
                                                        is-aviral RNA editing
                                                is-aRNA phosphodiester bond hydrolysis +
                                                is-aRNA processing +
                                                is-aRNA repair
                                                is-aRNA replication +
                                                is-aRNA secondary structure unwinding
                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular nitrogen compound metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular macromolecule metabolic process
                                        is-aRNA metabolic process
                                                is-alagging strand elongation +
                                                is-aleading strand elongation
                                                is-amitochondrial RNA metabolic process +
                                                is-amRNA metabolic process +
                                                is-ancRNA metabolic process +
                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                positively-regulatespositive regulation of RNA metabolic process +
                                                regulatesregulation of RNA metabolic process +
                                                is-aRNA biosynthetic process +
                                                is-aRNA catabolic process +
                                                is-aRNA exon ligation +
                                                is-aRNA folding
                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                        is-abase conversion or substitution editing +
                                                        is-achloroplast RNA modification +
                                                        is-amitochondrial RNA modification +
                                                        is-amRNA modification +
                                                        is-aoxidative RNA demethylation +
                                                        is-apseudouridine synthesis +
                                                        is-aRNA methylation +
                                                        is-aRNA nucleotide deletion +
                                                        is-aRNA nucleotide insertion +
                                                        is-arRNA modification +
                                                        is-asnRNA modification +
                                                        is-atRNA modification +
                                                        is-aviral RNA editing
                                                is-aRNA phosphodiester bond hydrolysis +
                                                is-aRNA processing +
                                                is-aRNA repair
                                                is-aRNA replication +
                                                is-aRNA secondary structure unwinding
                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular nitrogen compound metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-acellular nitrogen compound metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-acellular macromolecule metabolic process
                                                is-aRNA metabolic process
                                                        is-alagging strand elongation +
                                                        is-aleading strand elongation
                                                        is-amitochondrial RNA metabolic process +
                                                        is-amRNA metabolic process +
                                                        is-ancRNA metabolic process +
                                                        negatively-regulatesnegative regulation of RNA metabolic process +
                                                        positively-regulatespositive regulation of RNA metabolic process +
                                                        regulatesregulation of RNA metabolic process +
                                                        is-aRNA biosynthetic process +
                                                        is-aRNA catabolic process +
                                                        is-aRNA exon ligation +
                                                        is-aRNA folding
                                                        is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                is-abase conversion or substitution editing +
                                                                is-achloroplast RNA modification +
                                                                is-amitochondrial RNA modification +
                                                                is-amRNA modification +
                                                                is-aoxidative RNA demethylation +
                                                                is-apseudouridine synthesis +
                                                                is-aRNA methylation +
                                                                is-aRNA nucleotide deletion +
                                                                is-aRNA nucleotide insertion +
                                                                is-arRNA modification +
                                                                is-asnRNA modification +
                                                                is-atRNA modification +
                                                                is-aviral RNA editing
                                                        is-aRNA phosphodiester bond hydrolysis +
                                                        is-aRNA processing +
                                                        is-aRNA repair
                                                        is-aRNA replication +
                                                        is-aRNA secondary structure unwinding
                                                        is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-amacromolecule modification
                                                is-aDNA modification +
                                                is-amacromolecule glycosylation +
                                                is-amacromolecule methylation +
                                                is-aprotein modification process +
                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                        is-abase conversion or substitution editing +
                                                        is-achloroplast RNA modification +
                                                        is-amitochondrial RNA modification +
                                                        is-amRNA modification +
                                                        is-aoxidative RNA demethylation +
                                                        is-apseudouridine synthesis +
                                                        is-aRNA methylation +
                                                        is-aRNA nucleotide deletion +
                                                        is-aRNA nucleotide insertion +
                                                        is-arRNA modification +
                                                        is-asnRNA modification +
                                                        is-atRNA modification +
                                                        is-aviral RNA editing
                                                is-asialylation


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-anucleic acid metabolic process
                                                is-aRNA metabolic process
                                                        is-alagging strand elongation +
                                                        is-aleading strand elongation
                                                        is-amitochondrial RNA metabolic process +
                                                        is-amRNA metabolic process +
                                                        is-ancRNA metabolic process +
                                                        negatively-regulatesnegative regulation of RNA metabolic process +
                                                        positively-regulatespositive regulation of RNA metabolic process +
                                                        regulatesregulation of RNA metabolic process +
                                                        is-aRNA biosynthetic process +
                                                        is-aRNA catabolic process +
                                                        is-aRNA exon ligation +
                                                        is-aRNA folding
                                                        is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                is-abase conversion or substitution editing +
                                                                is-achloroplast RNA modification +
                                                                is-amitochondrial RNA modification +
                                                                is-amRNA modification +
                                                                is-aoxidative RNA demethylation +
                                                                is-apseudouridine synthesis +
                                                                is-aRNA methylation +
                                                                is-aRNA nucleotide deletion +
                                                                is-aRNA nucleotide insertion +
                                                                is-arRNA modification +
                                                                is-asnRNA modification +
                                                                is-atRNA modification +
                                                                is-aviral RNA editing
                                                        is-aRNA phosphodiester bond hydrolysis +
                                                        is-aRNA processing +
                                                        is-aRNA repair
                                                        is-aRNA replication +
                                                        is-aRNA secondary structure unwinding
                                                        is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic cyclic compound metabolic process
                                        is-anucleobase-containing compound metabolic process
                                                is-anucleic acid metabolic process
                                                        is-aRNA metabolic process
                                                                is-alagging strand elongation +
                                                                is-aleading strand elongation
                                                                is-amitochondrial RNA metabolic process +
                                                                is-amRNA metabolic process +
                                                                is-ancRNA metabolic process +
                                                                negatively-regulatesnegative regulation of RNA metabolic process +
                                                                positively-regulatespositive regulation of RNA metabolic process +
                                                                regulatesregulation of RNA metabolic process +
                                                                is-aRNA biosynthetic process +
                                                                is-aRNA catabolic process +
                                                                is-aRNA exon ligation +
                                                                is-aRNA folding
                                                                is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                        is-abase conversion or substitution editing +
                                                                        is-achloroplast RNA modification +
                                                                        is-amitochondrial RNA modification +
                                                                        is-amRNA modification +
                                                                        is-aoxidative RNA demethylation +
                                                                        is-apseudouridine synthesis +
                                                                        is-aRNA methylation +
                                                                        is-aRNA nucleotide deletion +
                                                                        is-aRNA nucleotide insertion +
                                                                        is-arRNA modification +
                                                                        is-asnRNA modification +
                                                                        is-atRNA modification +
                                                                        is-aviral RNA editing
                                                                is-aRNA phosphodiester bond hydrolysis +
                                                                is-aRNA processing +
                                                                is-aRNA repair
                                                                is-aRNA replication +
                                                                is-aRNA secondary structure unwinding
                                                                is-aviral double stranded DNA replication via reverse transcription


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-anucleobase-containing compound metabolic process
                                        is-anucleic acid metabolic process
                                                is-aRNA metabolic process
                                                        is-alagging strand elongation +
                                                        is-aleading strand elongation
                                                        is-amitochondrial RNA metabolic process +
                                                        is-amRNA metabolic process +
                                                        is-ancRNA metabolic process +
                                                        negatively-regulatesnegative regulation of RNA metabolic process +
                                                        positively-regulatespositive regulation of RNA metabolic process +
                                                        regulatesregulation of RNA metabolic process +
                                                        is-aRNA biosynthetic process +
                                                        is-aRNA catabolic process +
                                                        is-aRNA exon ligation +
                                                        is-aRNA folding
                                                        is-aRNA modification [GO:0009451] (64 genes, 117 annotations)
                                                                is-abase conversion or substitution editing +
                                                                is-achloroplast RNA modification +
                                                                is-amitochondrial RNA modification +
                                                                is-amRNA modification +
                                                                is-aoxidative RNA demethylation +
                                                                is-apseudouridine synthesis +
                                                                is-aRNA methylation +
                                                                is-aRNA nucleotide deletion +
                                                                is-aRNA nucleotide insertion +
                                                                is-arRNA modification +
                                                                is-asnRNA modification +
                                                                is-atRNA modification +
                                                                is-aviral RNA editing
                                                        is-aRNA phosphodiester bond hydrolysis +
                                                        is-aRNA processing +
                                                        is-aRNA repair
                                                        is-aRNA replication +
                                                        is-aRNA secondary structure unwinding
                                                        is-aviral double stranded DNA replication via reverse transcription


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory