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Gene Ontology Browser
Term Detail
GO term:cholesterol monooxygenase (side-chain-cleaving) activity
Synonym: C27-side chain cleavage enzyme
Synonym: cholesterol 20-22-desmolase activity
Synonym: cholesterol C(20-22) desmolase activity
Synonym: cholesterol C20-22 desmolase activity
Synonym: cholesterol desmolase activity
Synonym: cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Synonym: cholesterol side-chain cleavage enzyme activity
Synonym: cholesterol side-chain-cleaving enzyme activity
Synonym: Cyp11a1
Synonym: cytochrome p450scc
Synonym: cytochrome P-450scc
Synonym: cytochrome p450(scc) activity
Synonym: cytochrome P-450(scc) activity
Synonym: desmolase, steroid 20-22
Synonym: enzymes, cholesterol side-chain-cleaving
Synonym: steroid 20-22 desmolase activity
Synonym: steroid 20-22-lyase activity
GO id:GO:0008386
Definition:Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-amonooxygenase activity
                                        is-aoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
                                                is-a2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity
                                                is-a4-AD 9alpha-hydroxylase activity
                                                is-aADD 9alpha-hydroxylase activity
                                                is-aalkane 1-monooxygenase activity
                                                is-aarachidonic acid omega-hydroxylase activity
                                                is-aatrazine N-dealkylase activity
                                                is-abutane monooxygenase activity
                                                is-acamphor 1,2-monooxygenase activity
                                                is-acamphor 5-monooxygenase activity
                                                is-acholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386] (2 genes, 3 annotations)
                                                is-acholine monooxygenase activity
                                                is-acorticosterone 18-monooxygenase activity
                                                is-acyclohexane monooxygenase activity
                                                is-adeethylatrazine monooxygenase activity
                                                is-adeisopropylatrazine monooxygenase activity
                                                is-amidchain alkane hydroxylase activity
                                                is-aN-isopropylacetaniline monooxygenase activity
                                                is-asteroid 11-beta-monooxygenase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-amonooxygenase activity
                                        is-asteroid hydroxylase activity
                                                is-acholesterol 25-hydroxylase activity
                                                is-acholesterol 26-hydroxylase activity
                                                is-acholesterol 7-alpha-monooxygenase activity
                                                is-acholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386] (2 genes, 3 annotations)
                                                is-aecdysone 20-monooxygenase activity
                                                is-aecdysteroid 2-hydroxylase activity
                                                is-aecdysteroid 22-hydroxylase activity
                                                is-aecdysteroid 25-hydroxylase activity
                                                is-aoxysterol 7-alpha-hydroxylase activity
                                                is-asteroid 11-beta-monooxygenase activity
                                                is-asteroid 17-alpha-monooxygenase activity
                                                is-asteroid 21-monooxygenase activity
                                                is-asteroid 22-alpha hydroxylase activity
                                                is-asteroid 7-alpha-hydroxylase activity
                                                is-asterol 12-alpha-hydroxylase activity
                                                is-atestosterone 15-alpha-hydroxylase activity
                                                is-atestosterone 16-alpha-hydroxylase activity
                                                is-atestosterone 6-beta-hydroxylase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
                                        is-aoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
                                                is-a2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity
                                                is-a4-AD 9alpha-hydroxylase activity
                                                is-aADD 9alpha-hydroxylase activity
                                                is-aalkane 1-monooxygenase activity
                                                is-aarachidonic acid omega-hydroxylase activity
                                                is-aatrazine N-dealkylase activity
                                                is-abutane monooxygenase activity
                                                is-acamphor 1,2-monooxygenase activity
                                                is-acamphor 5-monooxygenase activity
                                                is-acholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386] (2 genes, 3 annotations)
                                                is-acholine monooxygenase activity
                                                is-acorticosterone 18-monooxygenase activity
                                                is-acyclohexane monooxygenase activity
                                                is-adeethylatrazine monooxygenase activity
                                                is-adeisopropylatrazine monooxygenase activity
                                                is-amidchain alkane hydroxylase activity
                                                is-aN-isopropylacetaniline monooxygenase activity
                                                is-asteroid 11-beta-monooxygenase activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory