| GO term: | pattern recognition receptor activity |
| Synonym: | macrophage receptor activity |
| GO id: | GO:0008329 |
| Definition: | Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens. |
| Comments | Note that this term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway; gene products which recognize polymeric structures such as polysaccharides or peptidoglycans in extracellular space, but are not directly coupled to signal transduction pathway, should use the term 'pattern binding ; GO:0001871' or its child terms. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'. |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functionmolecular transducer activitysignal transducer activitysignaling receptor activityadvanced glycation end-product receptor activityaryl hydrocarbon receptor activitycoreceptor activity +corticotropin-releasing hormone receptor activitydiuretic hormone receptor activityhigh molecular weight B cell growth factor receptor activityinositol 1,4,5-trisphosphate-sensitive calcium-release channel activityleucokinin receptor activityligand-activated RNA polymerase II transcription factor binding transcription factor activity +ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity +neurotransmitter receptor activity +neurotrophin receptor activity +pattern recognition receptor activity [GO:0008329] (14 genes, 17 annotations)lipoarabinomannan receptor activitylipopolysaccharide receptor activitylipoteichoic acid receptor activitypeptidoglycan receptor activitypolysaccharide receptor activity +peptide receptor activity +phorbol ester receptor activity +phosphorelay sensor kinase activityphotoreceptor activity +steroid hormone receptor activity +thrombospondin receptor activitytransmembrane signaling receptor activity +U-plasminogen activator receptor activitymolecular_functionreceptor activitysignaling receptor activityadvanced glycation end-product receptor activityaryl hydrocarbon receptor activitycoreceptor activity +corticotropin-releasing hormone receptor activitydiuretic hormone receptor activityhigh molecular weight B cell growth factor receptor activityinositol 1,4,5-trisphosphate-sensitive calcium-release channel activityleucokinin receptor activityligand-activated RNA polymerase II transcription factor binding transcription factor activity +ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity +neurotransmitter receptor activity +neurotrophin receptor activity +pattern recognition receptor activity [GO:0008329] (14 genes, 17 annotations)lipoarabinomannan receptor activitylipopolysaccharide receptor activitylipoteichoic acid receptor activitypeptidoglycan receptor activitypolysaccharide receptor activity +peptide receptor activity +phorbol ester receptor activity +phosphorelay sensor kinase activityphotoreceptor activity +steroid hormone receptor activity +thrombospondin receptor activitytransmembrane signaling receptor activity +U-plasminogen activator receptor activityMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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