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Gene Ontology Browser
Term Detail
GO term:signaling pattern recognition receptor activity
Synonym: macrophage receptor activity
Synonym: signaling PRR activity
GO id:GO:0008329
Definition:Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.
CommentsThis term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway. For pattern recognition receptors which do not relay an intracellular signal (e.g. endocytic pattern recognition receptors), consider instead annotating to 'pattern recognition receptor activity ; GO:0038187' and/or the child terms of 'pattern binding ; GO:0001871'. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-aadvanced glycation end-product receptor activity
                                        is-aaryl hydrocarbon receptor activity
                                        is-aauxin receptor activity
                                        is-abile acid receptor activity +
                                        is-acalcitriol receptor activity
                                        is-acoreceptor activity +
                                        is-adiuretic hormone receptor activity
                                        is-aethylene receptor activity +
                                        is-ahigh molecular weight B cell growth factor receptor activity
                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                        is-ajuvenile hormone receptor activity
                                        is-aleucokinin receptor activity
                                        is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                        is-aneurotransmitter receptor activity +
                                        is-aneurotrophin receptor activity +
                                        is-apeptide receptor activity +
                                        is-aphorbol ester receptor activity +
                                        is-aphosphorelay sensor kinase activity
                                        is-aphotoreceptor activity +
                                        is-aretinoic acid receptor activity +
                                        is-asignaling pattern recognition receptor activity [GO:0008329] (14 genes, 17 annotations)
                                                is-alipoarabinomannan receptor activity
                                                is-alipopolysaccharide receptor activity
                                                is-alipoteichoic acid receptor activity
                                                is-apeptidoglycan receptor activity
                                                is-apolysaccharide receptor activity +
                                        is-asteroid hormone receptor activity +
                                        is-athrombospondin receptor activity
                                        is-athyroid hormone receptor activity
                                        is-atransmembrane signaling receptor activity +
                                        is-aurokinase plasminogen activator receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-apattern recognition receptor activity
                                is-asignaling pattern recognition receptor activity [GO:0008329] (14 genes, 17 annotations)
                                        is-alipoarabinomannan receptor activity
                                        is-alipopolysaccharide receptor activity
                                        is-alipoteichoic acid receptor activity
                                        is-apeptidoglycan receptor activity
                                        is-apolysaccharide receptor activity +


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-aadvanced glycation end-product receptor activity
                                is-aaryl hydrocarbon receptor activity
                                is-aauxin receptor activity
                                is-abile acid receptor activity +
                                is-acalcitriol receptor activity
                                is-acoreceptor activity +
                                is-adiuretic hormone receptor activity
                                is-aethylene receptor activity +
                                is-ahigh molecular weight B cell growth factor receptor activity
                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                is-ajuvenile hormone receptor activity
                                is-aleucokinin receptor activity
                                is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                is-aneurotransmitter receptor activity +
                                is-aneurotrophin receptor activity +
                                is-apeptide receptor activity +
                                is-aphorbol ester receptor activity +
                                is-aphosphorelay sensor kinase activity
                                is-aphotoreceptor activity +
                                is-aretinoic acid receptor activity +
                                is-asignaling pattern recognition receptor activity [GO:0008329] (14 genes, 17 annotations)
                                        is-alipoarabinomannan receptor activity
                                        is-alipopolysaccharide receptor activity
                                        is-alipoteichoic acid receptor activity
                                        is-apeptidoglycan receptor activity
                                        is-apolysaccharide receptor activity +
                                is-asteroid hormone receptor activity +
                                is-athrombospondin receptor activity
                                is-athyroid hormone receptor activity
                                is-atransmembrane signaling receptor activity +
                                is-aurokinase plasminogen activator receptor activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory