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Gene Ontology Browser
Term Detail
GO term:cell aging
Synonym: cell ageing
GO id:GO:0007569
Definition:An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-a(+)-kotanin metabolic process +
                                is-a(-)-microperfuranone metabolic process +
                                is-a3-hydroxybenzyl alcohol metabolic process
                                is-a3alpha(S)-strictosidine biosynthetic process
                                is-a3alpha(S)-strictosidine catabolic process
                                is-a6-alpha-maltosylglucose metabolic process +
                                is-aacetyl-CoA biosynthetic process from ethanol
                                is-aacetylcholine metabolic process +
                                is-aactin cortical patch organization +
                                is-aactin filament-based process +
                                is-aalditol metabolic process +
                                is-aalkanesulfonate metabolic process +
                                is-aalpha-ribazole metabolic process +
                                is-aaminoglycoside antibiotic biosynthetic process +
                                is-aaminoglycoside antibiotic catabolic process +
                                is-aandrogen metabolic process +
                                is-aansamycin metabolic process +
                                is-aaromatic primary alcohol metabolic process +
                                is-aascospore wall chitin metabolic process +
                                is-aaspyridone A metabolic process +
                                is-aaspyridone B metabolic process +
                                is-aautolysis
                                is-aautophagy in response to ER overload
                                is-abeta-1,2-oligomannoside metabolic process +
                                is-ablood microparticle formation +
                                is-abrevianamide F metabolic process +
                                is-aC21-steroid hormone metabolic process +
                                is-acarbon fixation by acetyl-CoA pathway
                                is-acell activation +
                                is-acell adhesion molecule production +
                                is-acell aging [GO:0007569] (69 genes, 95 annotations)
                                        is-acellular senescence +
                                        is-achronological cell aging +
                                        negatively-regulatesnegative regulation of cell aging +
                                        part-ofnucleolar fragmentation +
                                        positively-regulatespositive regulation of cell aging +
                                        part-ofprogressive alteration of chromatin involved in cell aging +
                                        regulatesregulation of cell aging +
                                        is-areplicative cell aging +
                                        is-areplicative senescence
                                is-acell communication +
                                is-acell competition in a multicellular organism
                                is-acell cycle +
                                is-acell cycle process +
                                is-acell death +
                                is-acell division +
                                is-acell growth +
                                is-acell junction organization +
                                is-acell projection organization +
                                is-acell recognition +
                                is-acell wall beta-glucan metabolic process +
                                is-acellular alcohol metabolic process +
                                is-acellular aldehyde metabolic process +
                                is-acellular alkane metabolic process +
                                is-acellular alkyne metabolic process +
                                is-acellular carbohydrate biosynthetic process +
                                is-acellular component disassembly +
                                is-acellular component maintenance +
                                is-acellular component movement +
                                is-acellular detoxification of nitrogen compound
                                is-acellular developmental process +
                                is-acellular homeostasis +
                                is-acellular ketone body metabolic process +
                                is-acellular ketone metabolic process +
                                is-acellular lactam metabolic process +
                                is-acellular lipid metabolic process +
                                is-acellular oligosaccharide metabolic process +
                                is-acellular pigmentation +
                                is-acellular potassium ion transport +
                                is-achanoclavine-I metabolic process +
                                is-achlorophyll biosynthetic process +
                                is-achlorophyll catabolic process +
                                is-achromosome number maintenance
                                is-achromosome segregation +
                                is-acobalamin metabolic process +
                                is-acoenzyme M metabolic process +
                                is-aconiferin metabolic process
                                is-acontact inhibition +
                                is-acordyol C metabolic process +
                                is-acyanide metabolic process +
                                is-acyclohexanol metabolic process +
                                is-acytoplasm organization +
                                is-acytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
                                is-aD-arabinose catabolic process to xylulose 5-phosphate
                                is-adefense response by callose deposition in cell wall
                                is-ademethylkotanin metabolic process +
                                is-adendritic spine organization +
                                is-adhurrin biosynthetic process
                                is-adibenzo-p-dioxin metabolic process +
                                is-adibenzofuran metabolic process +
                                is-adimethyl ether metabolic process
                                is-adimethyl sulfoxide metabolic process
                                is-adimethylsilanediol metabolic process +
                                is-adiorcinol metabolic process +
                                is-adisaccharide metabolic process +
                                is-aDNA damage induced protein phosphorylation
                                is-aDNA demethylation +
                                is-aDNA repair +
                                is-adsRNA fragmentation +
                                is-aelectron transport chain +
                                is-aemericellamide metabolic process +
                                is-aenergy derivation by oxidation of organic compounds +
                                is-aenergy derivation by oxidation of reduced inorganic compounds +
                                is-aensheathment of neurons +
                                is-aEntner-Doudoroff pathway
                                is-aepithelial cell proliferation involved in prostate gland development +
                                is-aepoxide metabolic process +
                                is-aER-associated misfolded protein catabolic process
                                is-aergot alkaloid biosynthetic process +
                                is-aergot alkaloid catabolic process +
                                is-aestablishment or maintenance of cell polarity +
                                is-aestablishment or maintenance of cell type involved in phenotypic switching
                                is-aestrogen metabolic process +
                                is-aethanolamine-containing compound metabolic process +
                                is-aexecution phase of apoptosis +
                                is-aexecution phase of necroptosis
                                is-aextracellular structure organization +
                                is-aF-9775A metabolic process +
                                is-aF-9775B metabolic process +
                                is-afibril organization +
                                is-afumitremorgin B metabolic process +
                                is-agalactose to glucose-1-phosphate metabolic process
                                is-agene silencing +
                                is-aglucose import in response to insulin stimulus +
                                is-aglycerol ether biosynthetic process +
                                is-aglycerol ether catabolic process
                                is-aglycolytic process +
                                is-ahalogenated hydrocarbon metabolic process +
                                is-aheme metabolic process +
                                is-ahydrogen peroxide catabolic process +
                                is-ainositol metabolic process +
                                is-ainositol phosphate metabolic process +
                                is-aintermediate filament-based process +
                                is-aL-arabinose catabolic process to xylulose 5-phosphate
                                is-alight absorption +
                                is-amacrolide metabolic process +
                                is-amaintenance of blood-brain barrier
                                is-amaintenance of location in cell +
                                is-amannose to fructose-6-phosphate metabolic process
                                is-aMAPK import into nucleus involved in conjugation with cellular fusion
                                is-aMAPK import into nucleus involved in innate immune response
                                is-amelanin metabolic process +
                                is-amembrane docking +
                                is-amesenchymal cell proliferation involved in prostate gland development +
                                is-amethyl tert-butyl ether metabolic process
                                is-amicroautophagy +
                                is-amicrotubule organizing center attachment site organization
                                is-amicrotubule-based process +
                                is-amineralocorticoid metabolic process +
                                is-amRNA export from nucleus in response to heat stress +
                                is-amycothiol metabolic process +
                                is-anicotinamide metabolic process +
                                is-anucleobase-containing small molecule metabolic process +
                                is-anucleoid organization +
                                is-anucleus-associated proteasomal ubiquitin-dependent protein catabolic process +
                                is-aommochrome metabolic process +
                                is-aone-carbon metabolic process +
                                is-aorcinol metabolic process +
                                is-aorganic acid metabolic process +
                                is-aorlandin metabolic process +
                                is-aoxidative RNA demethylation +
                                is-aoxytetracycline metabolic process +
                                is-apeptide pheromone export involved in conjugation with cellular fusion
                                is-apeptidoglycan biosynthetic process +
                                is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                is-aperiplasmic space organization
                                is-aphenolic phthiocerol biosynthetic process
                                is-aphenylpropanoid metabolic process +
                                is-apheromone metabolic process +
                                is-aphotoreceptor cell outer segment organization
                                is-aphytochelatin metabolic process +
                                is-aphytol salvage
                                is-aplasma membrane fusion +
                                is-aplasma membrane organization involved in conjugation with cellular fusion
                                is-aplasmid maintenance +
                                is-aplastoglobule organization
                                is-apollen adhesion
                                is-apollen wall assembly +
                                is-apolythionate oxidation
                                is-apronuclear envelope synthesis +
                                is-aprotein demethylation +
                                is-aprotein glycosylation +
                                is-aprotein halogenation +
                                is-aprotein oxidation +
                                is-apteridine biosynthetic process
                                is-areceptor internalization +
                                is-aregulation of cellular component size +
                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +
                                is-aremoval of superoxide radicals +
                                is-areplication fork processing +
                                is-areversion of cell type to default state involved in phenotypic switching
                                is-arhamnogalacturonan I biosynthetic process
                                is-arhodopsin metabolic process +
                                is-ariboflavin metabolic process +
                                is-aS-glycoside metabolic process +
                                is-asecretion by cell +
                                is-aSertoli cell proliferation
                                is-asiderophore metabolic process +
                                is-asignal maturation +
                                is-asignal transduction by phosphorylation +
                                is-asingle-celled organism vegetative growth phase +
                                is-asingle-organism intercellular transport +
                                is-asingle-organism organelle organization +
                                is-aspecification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
                                is-asperm entry
                                is-aspore wall assembly +
                                is-astomatal movement +
                                is-asulfate reduction +
                                is-asulfide oxidation +
                                is-asulfur oxidation +
                                is-asynapse organization +
                                is-asyncytium formation +
                                is-atensidol A metabolic process +
                                is-aterminal button organization +
                                is-atetracycline metabolic process +
                                is-athiamine-containing compound metabolic process +
                                is-atoluene oxidation +
                                is-atoxin metabolic process +
                                is-atransmembrane transport +
                                is-atransposition +
                                is-aurea metabolic process +
                                is-averruculogen metabolic process +
                                is-avesicle targeting +
                                is-avesicle-mediated transport involved in floral organ abscission +
                                is-aviolaceol I metabolic process +
                                is-aviolaceol II metabolic process +
                                is-avistamycin metabolic process +
                                is-avitamin B6 metabolic process +
                                is-avitamin biosynthetic process +
                                is-avitamin catabolic process +
                                is-avitamin E metabolic process +
                                is-awybutosine biosynthetic process


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-aaging
                                        part-ofage-dependent behavioral decline
                                        part-ofage-dependent general metabolic decline +
                                        is-acell aging [GO:0007569] (69 genes, 95 annotations)
                                                is-acellular senescence +
                                                is-achronological cell aging +
                                                negatively-regulatesnegative regulation of cell aging +
                                                part-ofnucleolar fragmentation +
                                                positively-regulatespositive regulation of cell aging +
                                                part-ofprogressive alteration of chromatin involved in cell aging +
                                                regulatesregulation of cell aging +
                                                is-areplicative cell aging +
                                                is-areplicative senescence
                                        is-afruit ripening +
                                        is-amulticellular organismal aging +
                                        is-aorgan senescence +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-a(+)-kotanin metabolic process +
                                is-a(-)-microperfuranone metabolic process +
                                is-a3-hydroxybenzyl alcohol metabolic process
                                is-a3alpha(S)-strictosidine biosynthetic process
                                is-a3alpha(S)-strictosidine catabolic process
                                is-a6-alpha-maltosylglucose metabolic process +
                                is-aacetyl-CoA biosynthetic process from ethanol
                                is-aacetylcholine metabolic process +
                                is-aactin cortical patch organization +
                                is-aactin filament-based process +
                                is-aalditol metabolic process +
                                is-aalkanesulfonate metabolic process +
                                is-aalpha-ribazole metabolic process +
                                is-aaminoglycoside antibiotic biosynthetic process +
                                is-aaminoglycoside antibiotic catabolic process +
                                is-aandrogen metabolic process +
                                is-aansamycin metabolic process +
                                is-aaromatic primary alcohol metabolic process +
                                is-aascospore wall chitin metabolic process +
                                is-aaspyridone A metabolic process +
                                is-aaspyridone B metabolic process +
                                is-aautolysis
                                is-aautophagy in response to ER overload
                                is-abeta-1,2-oligomannoside metabolic process +
                                is-ablood microparticle formation +
                                is-abrevianamide F metabolic process +
                                is-aC21-steroid hormone metabolic process +
                                is-acarbon fixation by acetyl-CoA pathway
                                is-acell activation +
                                is-acell adhesion molecule production +
                                is-acell aging [GO:0007569] (69 genes, 95 annotations)
                                        is-acellular senescence +
                                        is-achronological cell aging +
                                        negatively-regulatesnegative regulation of cell aging +
                                        part-ofnucleolar fragmentation +
                                        positively-regulatespositive regulation of cell aging +
                                        part-ofprogressive alteration of chromatin involved in cell aging +
                                        regulatesregulation of cell aging +
                                        is-areplicative cell aging +
                                        is-areplicative senescence
                                is-acell communication +
                                is-acell competition in a multicellular organism
                                is-acell cycle +
                                is-acell cycle process +
                                is-acell death +
                                is-acell division +
                                is-acell growth +
                                is-acell junction organization +
                                is-acell projection organization +
                                is-acell recognition +
                                is-acell wall beta-glucan metabolic process +
                                is-acellular alcohol metabolic process +
                                is-acellular aldehyde metabolic process +
                                is-acellular alkane metabolic process +
                                is-acellular alkyne metabolic process +
                                is-acellular carbohydrate biosynthetic process +
                                is-acellular component disassembly +
                                is-acellular component maintenance +
                                is-acellular component movement +
                                is-acellular detoxification of nitrogen compound
                                is-acellular developmental process +
                                is-acellular homeostasis +
                                is-acellular ketone body metabolic process +
                                is-acellular ketone metabolic process +
                                is-acellular lactam metabolic process +
                                is-acellular lipid metabolic process +
                                is-acellular oligosaccharide metabolic process +
                                is-acellular pigmentation +
                                is-acellular potassium ion transport +
                                is-achanoclavine-I metabolic process +
                                is-achlorophyll biosynthetic process +
                                is-achlorophyll catabolic process +
                                is-achromosome number maintenance
                                is-achromosome segregation +
                                is-acobalamin metabolic process +
                                is-acoenzyme M metabolic process +
                                is-aconiferin metabolic process
                                is-acontact inhibition +
                                is-acordyol C metabolic process +
                                is-acyanide metabolic process +
                                is-acyclohexanol metabolic process +
                                is-acytoplasm organization +
                                is-acytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
                                is-aD-arabinose catabolic process to xylulose 5-phosphate
                                is-adefense response by callose deposition in cell wall
                                is-ademethylkotanin metabolic process +
                                is-adendritic spine organization +
                                is-adhurrin biosynthetic process
                                is-adibenzo-p-dioxin metabolic process +
                                is-adibenzofuran metabolic process +
                                is-adimethyl ether metabolic process
                                is-adimethyl sulfoxide metabolic process
                                is-adimethylsilanediol metabolic process +
                                is-adiorcinol metabolic process +
                                is-adisaccharide metabolic process +
                                is-aDNA damage induced protein phosphorylation
                                is-aDNA demethylation +
                                is-aDNA repair +
                                is-adsRNA fragmentation +
                                is-aelectron transport chain +
                                is-aemericellamide metabolic process +
                                is-aenergy derivation by oxidation of organic compounds +
                                is-aenergy derivation by oxidation of reduced inorganic compounds +
                                is-aensheathment of neurons +
                                is-aEntner-Doudoroff pathway
                                is-aepithelial cell proliferation involved in prostate gland development +
                                is-aepoxide metabolic process +
                                is-aER-associated misfolded protein catabolic process
                                is-aergot alkaloid biosynthetic process +
                                is-aergot alkaloid catabolic process +
                                is-aestablishment or maintenance of cell polarity +
                                is-aestablishment or maintenance of cell type involved in phenotypic switching
                                is-aestrogen metabolic process +
                                is-aethanolamine-containing compound metabolic process +
                                is-aexecution phase of apoptosis +
                                is-aexecution phase of necroptosis
                                is-aextracellular structure organization +
                                is-aF-9775A metabolic process +
                                is-aF-9775B metabolic process +
                                is-afibril organization +
                                is-afumitremorgin B metabolic process +
                                is-agalactose to glucose-1-phosphate metabolic process
                                is-agene silencing +
                                is-aglucose import in response to insulin stimulus +
                                is-aglycerol ether biosynthetic process +
                                is-aglycerol ether catabolic process
                                is-aglycolytic process +
                                is-ahalogenated hydrocarbon metabolic process +
                                is-aheme metabolic process +
                                is-ahydrogen peroxide catabolic process +
                                is-ainositol metabolic process +
                                is-ainositol phosphate metabolic process +
                                is-aintermediate filament-based process +
                                is-aL-arabinose catabolic process to xylulose 5-phosphate
                                is-alight absorption +
                                is-amacrolide metabolic process +
                                is-amaintenance of blood-brain barrier
                                is-amaintenance of location in cell +
                                is-amannose to fructose-6-phosphate metabolic process
                                is-aMAPK import into nucleus involved in conjugation with cellular fusion
                                is-aMAPK import into nucleus involved in innate immune response
                                is-amelanin metabolic process +
                                is-amembrane docking +
                                is-amesenchymal cell proliferation involved in prostate gland development +
                                is-amethyl tert-butyl ether metabolic process
                                is-amicroautophagy +
                                is-amicrotubule organizing center attachment site organization
                                is-amicrotubule-based process +
                                is-amineralocorticoid metabolic process +
                                is-amRNA export from nucleus in response to heat stress +
                                is-amycothiol metabolic process +
                                is-anicotinamide metabolic process +
                                is-anucleobase-containing small molecule metabolic process +
                                is-anucleoid organization +
                                is-anucleus-associated proteasomal ubiquitin-dependent protein catabolic process +
                                is-aommochrome metabolic process +
                                is-aone-carbon metabolic process +
                                is-aorcinol metabolic process +
                                is-aorganic acid metabolic process +
                                is-aorlandin metabolic process +
                                is-aoxidative RNA demethylation +
                                is-aoxytetracycline metabolic process +
                                is-apeptide pheromone export involved in conjugation with cellular fusion
                                is-apeptidoglycan biosynthetic process +
                                is-apeptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
                                is-aperiplasmic space organization
                                is-aphenolic phthiocerol biosynthetic process
                                is-aphenylpropanoid metabolic process +
                                is-apheromone metabolic process +
                                is-aphotoreceptor cell outer segment organization
                                is-aphytochelatin metabolic process +
                                is-aphytol salvage
                                is-aplasma membrane fusion +
                                is-aplasma membrane organization involved in conjugation with cellular fusion
                                is-aplasmid maintenance +
                                is-aplastoglobule organization
                                is-apollen adhesion
                                is-apollen wall assembly +
                                is-apolythionate oxidation
                                is-apronuclear envelope synthesis +
                                is-aprotein demethylation +
                                is-aprotein glycosylation +
                                is-aprotein halogenation +
                                is-aprotein oxidation +
                                is-apteridine biosynthetic process
                                is-areceptor internalization +
                                is-aregulation of cellular component size +
                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +
                                is-aremoval of superoxide radicals +
                                is-areplication fork processing +
                                is-areversion of cell type to default state involved in phenotypic switching
                                is-arhamnogalacturonan I biosynthetic process
                                is-arhodopsin metabolic process +
                                is-ariboflavin metabolic process +
                                is-aS-glycoside metabolic process +
                                is-asecretion by cell +
                                is-aSertoli cell proliferation
                                is-asiderophore metabolic process +
                                is-asignal maturation +
                                is-asignal transduction by phosphorylation +
                                is-asingle-celled organism vegetative growth phase +
                                is-asingle-organism intercellular transport +
                                is-asingle-organism organelle organization +
                                is-aspecification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
                                is-asperm entry
                                is-aspore wall assembly +
                                is-astomatal movement +
                                is-asulfate reduction +
                                is-asulfide oxidation +
                                is-asulfur oxidation +
                                is-asynapse organization +
                                is-asyncytium formation +
                                is-atensidol A metabolic process +
                                is-aterminal button organization +
                                is-atetracycline metabolic process +
                                is-athiamine-containing compound metabolic process +
                                is-atoluene oxidation +
                                is-atoxin metabolic process +
                                is-atransmembrane transport +
                                is-atransposition +
                                is-aurea metabolic process +
                                is-averruculogen metabolic process +
                                is-avesicle targeting +
                                is-avesicle-mediated transport involved in floral organ abscission +
                                is-aviolaceol I metabolic process +
                                is-aviolaceol II metabolic process +
                                is-avistamycin metabolic process +
                                is-avitamin B6 metabolic process +
                                is-avitamin biosynthetic process +
                                is-avitamin catabolic process +
                                is-avitamin E metabolic process +
                                is-awybutosine biosynthetic process


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-aaging
                                        part-ofage-dependent behavioral decline
                                        part-ofage-dependent general metabolic decline +
                                        is-acell aging [GO:0007569] (69 genes, 95 annotations)
                                                is-acellular senescence +
                                                is-achronological cell aging +
                                                negatively-regulatesnegative regulation of cell aging +
                                                part-ofnucleolar fragmentation +
                                                positively-regulatespositive regulation of cell aging +
                                                part-ofprogressive alteration of chromatin involved in cell aging +
                                                regulatesregulation of cell aging +
                                                is-areplicative cell aging +
                                                is-areplicative senescence
                                        is-afruit ripening +
                                        is-amulticellular organismal aging +
                                        is-aorgan senescence +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory