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Gene Ontology Browser
Term Detail
GO term:complement activation, classical pathway
Synonym: complement cascade, classical pathway
GO id:GO:0006958
Definition:Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
Number of paths to term: 38

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-apositive regulation of biological process
                                        is-apositive regulation of immune system process
                                                is-apositive regulation of immune response
                                                        is-aactivation of immune response
                                                                is-acomplement activation
                                                                        is-aactivation of membrane attack complex +
                                                                        is-acomplement activation, alternative pathway +
                                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        is-acomplement activation, lectin pathway +
                                                                        negatively-regulatesnegative regulation of complement activation +
                                                                        positively-regulatespositive regulation of complement activation +
                                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-apositive regulation of biological process
                                        is-apositive regulation of response to stimulus
                                                is-apositive regulation of immune response
                                                        is-aactivation of immune response
                                                                is-acomplement activation
                                                                        is-aactivation of membrane attack complex +
                                                                        is-acomplement activation, alternative pathway +
                                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        is-acomplement activation, lectin pathway +
                                                                        negatively-regulatesnegative regulation of complement activation +
                                                                        positively-regulatespositive regulation of complement activation +
                                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of immune system process
                                        is-apositive regulation of immune system process
                                                is-apositive regulation of immune response
                                                        is-aactivation of immune response
                                                                is-acomplement activation
                                                                        is-aactivation of membrane attack complex +
                                                                        is-acomplement activation, alternative pathway +
                                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        is-acomplement activation, lectin pathway +
                                                                        negatively-regulatesnegative regulation of complement activation +
                                                                        positively-regulatespositive regulation of complement activation +
                                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of immune system process
                                        is-aregulation of immune response
                                                is-apositive regulation of immune response
                                                        is-aactivation of immune response
                                                                is-acomplement activation
                                                                        is-aactivation of membrane attack complex +
                                                                        is-acomplement activation, alternative pathway +
                                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        is-acomplement activation, lectin pathway +
                                                                        negatively-regulatesnegative regulation of complement activation +
                                                                        positively-regulatespositive regulation of complement activation +
                                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-apositive regulation of response to stimulus
                                                is-apositive regulation of immune response
                                                        is-aactivation of immune response
                                                                is-acomplement activation
                                                                        is-aactivation of membrane attack complex +
                                                                        is-acomplement activation, alternative pathway +
                                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        is-acomplement activation, lectin pathway +
                                                                        negatively-regulatesnegative regulation of complement activation +
                                                                        positively-regulatespositive regulation of complement activation +
                                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of immune response
                                                is-apositive regulation of immune response
                                                        is-aactivation of immune response
                                                                is-acomplement activation
                                                                        is-aactivation of membrane attack complex +
                                                                        is-acomplement activation, alternative pathway +
                                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        is-acomplement activation, lectin pathway +
                                                                        negatively-regulatesnegative regulation of complement activation +
                                                                        positively-regulatespositive regulation of complement activation +
                                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aactivation of immune response
                                is-acomplement activation
                                        is-aactivation of membrane attack complex +
                                        is-acomplement activation, alternative pathway +
                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                regulatesregulation of complement activation, classical pathway +
                                        is-acomplement activation, lectin pathway +
                                        negatively-regulatesnegative regulation of complement activation +
                                        positively-regulatespositive regulation of complement activation +
                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune effector process
                                is-acomplement activation
                                        is-aactivation of membrane attack complex +
                                        is-acomplement activation, alternative pathway +
                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                regulatesregulation of complement activation, classical pathway +
                                        is-acomplement activation, lectin pathway +
                                        negatively-regulatesnegative regulation of complement activation +
                                        positively-regulatespositive regulation of complement activation +
                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune effector process
                                is-aleukocyte mediated immunity
                                        is-alymphocyte mediated immunity
                                                is-aB cell mediated immunity
                                                        is-aimmunoglobulin mediated immune response
                                                                is-ahumoral immune response mediated by circulating immunoglobulin
                                                                        part-ofcomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        negatively-regulatesnegative regulation of humoral immune response mediated by circulating immunoglobulin +
                                                                        positively-regulatespositive regulation of humoral immune response mediated by circulating immunoglobulin +
                                                                        regulatesregulation of humoral immune response mediated by circulating immunoglobulin +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                is-aadaptive immune response
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
                                                is-aB cell mediated immunity
                                                        is-aimmunoglobulin mediated immune response
                                                                is-ahumoral immune response mediated by circulating immunoglobulin
                                                                        part-ofcomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        negatively-regulatesnegative regulation of humoral immune response mediated by circulating immunoglobulin +
                                                                        positively-regulatespositive regulation of humoral immune response mediated by circulating immunoglobulin +
                                                                        regulatesregulation of humoral immune response mediated by circulating immunoglobulin +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                is-ahumoral immune response
                                        is-acomplement activation
                                                is-aactivation of membrane attack complex +
                                                is-acomplement activation, alternative pathway +
                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                        regulatesregulation of complement activation, classical pathway +
                                                is-acomplement activation, lectin pathway +
                                                negatively-regulatesnegative regulation of complement activation +
                                                positively-regulatespositive regulation of complement activation +
                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                is-ahumoral immune response
                                        is-ahumoral immune response mediated by circulating immunoglobulin
                                                part-ofcomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                        regulatesregulation of complement activation, classical pathway +
                                                negatively-regulatesnegative regulation of humoral immune response mediated by circulating immunoglobulin +
                                                positively-regulatespositive regulation of humoral immune response mediated by circulating immunoglobulin +
                                                regulatesregulation of humoral immune response mediated by circulating immunoglobulin +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                positively-regulatespositive regulation of immune response
                                        is-aactivation of immune response
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                regulatesregulation of immune response
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        positively-regulatespositive regulation of immune system process
                                is-apositive regulation of immune response
                                        is-aactivation of immune response
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        regulatesregulation of immune system process
                                is-apositive regulation of immune system process
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        regulatesregulation of immune system process
                                is-aregulation of immune response
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein activation cascade
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein activation cascade
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-aprotein activation cascade
                                        is-acomplement activation
                                                is-aactivation of membrane attack complex +
                                                is-acomplement activation, alternative pathway +
                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                        regulatesregulation of complement activation, classical pathway +
                                                is-acomplement activation, lectin pathway +
                                                negatively-regulatesnegative regulation of complement activation +
                                                positively-regulatespositive regulation of complement activation +
                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                positively-regulatespositive regulation of biological process
                        is-apositive regulation of immune system process
                                is-apositive regulation of immune response
                                        is-aactivation of immune response
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                positively-regulatespositive regulation of biological process
                        is-apositive regulation of response to stimulus
                                is-apositive regulation of immune response
                                        is-aactivation of immune response
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-apositive regulation of biological process
                                is-apositive regulation of immune system process
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-apositive regulation of biological process
                                is-apositive regulation of response to stimulus
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of immune system process
                                is-apositive regulation of immune system process
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of immune system process
                                is-aregulation of immune response
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of response to stimulus
                                is-apositive regulation of response to stimulus
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of response to stimulus
                                is-aregulation of immune response
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                is-aadaptive immune response
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
                                                is-aB cell mediated immunity
                                                        is-aimmunoglobulin mediated immune response
                                                                is-ahumoral immune response mediated by circulating immunoglobulin
                                                                        part-ofcomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                                regulatesregulation of complement activation, classical pathway +
                                                                        negatively-regulatesnegative regulation of humoral immune response mediated by circulating immunoglobulin +
                                                                        positively-regulatespositive regulation of humoral immune response mediated by circulating immunoglobulin +
                                                                        regulatesregulation of humoral immune response mediated by circulating immunoglobulin +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                is-ahumoral immune response
                                        is-acomplement activation
                                                is-aactivation of membrane attack complex +
                                                is-acomplement activation, alternative pathway +
                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                        regulatesregulation of complement activation, classical pathway +
                                                is-acomplement activation, lectin pathway +
                                                negatively-regulatesnegative regulation of complement activation +
                                                positively-regulatespositive regulation of complement activation +
                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                is-ahumoral immune response
                                        is-ahumoral immune response mediated by circulating immunoglobulin
                                                part-ofcomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                        regulatesregulation of complement activation, classical pathway +
                                                negatively-regulatesnegative regulation of humoral immune response mediated by circulating immunoglobulin +
                                                positively-regulatespositive regulation of humoral immune response mediated by circulating immunoglobulin +
                                                regulatesregulation of humoral immune response mediated by circulating immunoglobulin +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                positively-regulatespositive regulation of immune response
                                        is-aactivation of immune response
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                regulatesregulation of immune response
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        positively-regulatespositive regulation of response to stimulus
                                is-apositive regulation of immune response
                                        is-aactivation of immune response
                                                is-acomplement activation
                                                        is-aactivation of membrane attack complex +
                                                        is-acomplement activation, alternative pathway +
                                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                                regulatesregulation of complement activation, classical pathway +
                                                        is-acomplement activation, lectin pathway +
                                                        negatively-regulatesnegative regulation of complement activation +
                                                        positively-regulatespositive regulation of complement activation +
                                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aprotein activation cascade
                                is-acomplement activation
                                        is-aactivation of membrane attack complex +
                                        is-acomplement activation, alternative pathway +
                                        is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                positively-regulatespositive regulation of complement activation, classical pathway +
                                                regulatesregulation of complement activation, classical pathway +
                                        is-acomplement activation, lectin pathway +
                                        negatively-regulatesnegative regulation of complement activation +
                                        positively-regulatespositive regulation of complement activation +
                                        regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        regulatesregulation of response to stimulus
                                is-apositive regulation of response to stimulus
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        regulatesregulation of response to stimulus
                                is-aregulation of immune response
                                        is-apositive regulation of immune response
                                                is-aactivation of immune response
                                                        is-acomplement activation
                                                                is-aactivation of membrane attack complex +
                                                                is-acomplement activation, alternative pathway +
                                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                                        regulatesregulation of complement activation, classical pathway +
                                                                is-acomplement activation, lectin pathway +
                                                                negatively-regulatesnegative regulation of complement activation +
                                                                positively-regulatespositive regulation of complement activation +
                                                                regulatesregulation of complement activation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-aprotein activation cascade
                                        is-acomplement activation
                                                is-aactivation of membrane attack complex +
                                                is-acomplement activation, alternative pathway +
                                                is-acomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)
                                                        negatively-regulatesnegative regulation of complement activation, classical pathway +
                                                        positively-regulatespositive regulation of complement activation, classical pathway +
                                                        regulatesregulation of complement activation, classical pathway +
                                                is-acomplement activation, lectin pathway +
                                                negatively-regulatesnegative regulation of complement activation +
                                                positively-regulatespositive regulation of complement activation +
                                                regulatesregulation of complement activation +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory