| GO term: | complement activation, classical pathway |
| Synonym: | complement cascade, classical pathway |
| GO id: | GO:0006958 |
| Definition: | Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. |
| Number of paths to term: | 37 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processpositive regulation of biological processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processbiological regulationregulation of biological processpositive regulation of biological processpositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processbiological regulationregulation of biological processregulation of immune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processbiological regulationregulation of biological processregulation of immune system processregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processbiological regulationregulation of biological processregulation of response to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processbiological regulationregulation of biological processregulation of response to stimulusregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processimmune effector processcomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processimmune effector processleukocyte mediated immunitylymphocyte mediated immunityB cell mediated immunityimmunoglobulin mediated immune responsehumoral immune response mediated by circulating immunoglobulincomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +negative regulation of humoral immune response mediated by circulating immunoglobulinpositive regulation of humoral immune response mediated by circulating immunoglobulinregulation of humoral immune response mediated by circulating immunoglobulin +biological_processimmune system processimmune responseadaptive immune responseadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsB cell mediated immunityimmunoglobulin mediated immune responsehumoral immune response mediated by circulating immunoglobulincomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +negative regulation of humoral immune response mediated by circulating immunoglobulinpositive regulation of humoral immune response mediated by circulating immunoglobulinregulation of humoral immune response mediated by circulating immunoglobulin +biological_processimmune system processimmune responsehumoral immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processimmune responsehumoral immune responsehumoral immune response mediated by circulating immunoglobulincomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +negative regulation of humoral immune response mediated by circulating immunoglobulinpositive regulation of humoral immune response mediated by circulating immunoglobulinregulation of humoral immune response mediated by circulating immunoglobulin +biological_processimmune system processimmune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processimmune responseregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processregulation of immune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processimmune system processregulation of immune system processregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processprotein metabolic processprotein activation cascadecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processmetabolic processprimary metabolic processprotein metabolic processprotein activation cascadecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processpositive regulation of biological processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processpositive regulation of biological processpositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processregulation of biological processpositive regulation of biological processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processregulation of biological processpositive regulation of biological processpositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processregulation of biological processregulation of immune system processpositive regulation of immune system processpositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processregulation of biological processregulation of immune system processregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processregulation of biological processregulation of response to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processregulation of biological processregulation of response to stimulusregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimulusimmune responseadaptive immune responseadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsB cell mediated immunityimmunoglobulin mediated immune responsehumoral immune response mediated by circulating immunoglobulincomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +negative regulation of humoral immune response mediated by circulating immunoglobulinpositive regulation of humoral immune response mediated by circulating immunoglobulinregulation of humoral immune response mediated by circulating immunoglobulin +biological_processresponse to stimulusimmune responsehumoral immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimulusimmune responsehumoral immune responsehumoral immune response mediated by circulating immunoglobulincomplement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +negative regulation of humoral immune response mediated by circulating immunoglobulinpositive regulation of humoral immune response mediated by circulating immunoglobulinregulation of humoral immune response mediated by circulating immunoglobulin +biological_processresponse to stimulusimmune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimulusimmune responseregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimulusprotein activation cascadecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimulusregulation of response to stimuluspositive regulation of response to stimuluspositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processresponse to stimulusregulation of response to stimulusregulation of immune responsepositive regulation of immune responseactivation of immune responsecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +biological_processsingle-organism processprotein activation cascadecomplement activationactivation of membrane attack complex +complement activation, alternative pathway +complement activation, classical pathway [GO:0006958] (31 genes, 32 annotations)negative regulation of complement activation, classical pathway +positive regulation of complement activation, classical pathway +regulation of complement activation, classical pathway +complement activation, lectin pathway +negative regulation of complement activation +positive regulation of complement activation +regulation of complement activation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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