| GO term: | tricarboxylic acid cycle |
| Synonym: | citric acid cycle |
| Synonym: | Krebs cycle |
| Synonym: | TCA cycle |
| GO id: | GO:0006099 |
| Definition: | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
| Number of paths to term: | 4 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processcellular metabolic processgeneration of precursor metabolites and energyenergy derivation by oxidation of organic compoundscellular respirationaerobic respirationaerobic electron transport chainaerobic respiration, using ammonia as electron donoraerobic respiration, using arsenite as electron donoraerobic respiration, using carbon monoxide as electron donoraerobic respiration, using ferrous ions as electron donoraerobic respiration, using hydrogen as electron donoraerobic respiration, using nitrite as electron donoraerobic respiration, using sulfur or sulfate as electron donoralternative respirationtricarboxylic acid cycle [GO:0006099] (27 genes, 27 annotations)reductive tricarboxylic acid cyclebiological_processmetabolic processcellular metabolic processgeneration of precursor metabolites and energyenergy derivation by oxidation of organic compoundscellular respirationaerobic respirationaerobic electron transport chainaerobic respiration, using ammonia as electron donoraerobic respiration, using arsenite as electron donoraerobic respiration, using carbon monoxide as electron donoraerobic respiration, using ferrous ions as electron donoraerobic respiration, using hydrogen as electron donoraerobic respiration, using nitrite as electron donoraerobic respiration, using sulfur or sulfate as electron donoralternative respirationtricarboxylic acid cycle [GO:0006099] (27 genes, 27 annotations)reductive tricarboxylic acid cyclebiological_processmetabolic processprimary metabolic processcarbohydrate metabolic process +cellular amino acid metabolic process +lipid metabolic process +nucleobase-containing compound metabolic process +protein metabolic process +regulation of primary metabolic process +tricarboxylic acid cycle [GO:0006099] (27 genes, 27 annotations)reductive tricarboxylic acid cyclebiological_processmetabolic processsingle-organism metabolic processoxidation-reduction processenergy derivation by oxidation of organic compoundscellular respirationaerobic respirationaerobic electron transport chainaerobic respiration, using ammonia as electron donoraerobic respiration, using arsenite as electron donoraerobic respiration, using carbon monoxide as electron donoraerobic respiration, using ferrous ions as electron donoraerobic respiration, using hydrogen as electron donoraerobic respiration, using nitrite as electron donoraerobic respiration, using sulfur or sulfate as electron donoralternative respirationtricarboxylic acid cycle [GO:0006099] (27 genes, 27 annotations)reductive tricarboxylic acid cycleMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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