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Gene Ontology Browser
Term Detail
GO term:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Synonym: inositol-1,4,5-trisphosphate receptor activity
Synonym: InsP3 receptor
Synonym: IP3 receptor activity
GO id:GO:0005220
Definition:Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
Number of paths to term: 26

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-areceptor signaling protein activity
                                        is-aethylene receptor activity +
                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                        is-aphosphorelay response regulator activity
                                        is-aphosphorelay sensor kinase activity
                                        is-areceptor signaling protein serine/threonine kinase activity +
                                        is-areceptor signaling protein serine/threonine phosphatase activity
                                        is-areceptor signaling protein tyrosine kinase activity
                                        is-areceptor signaling protein tyrosine phosphatase activity
                                        is-atransforming growth factor beta receptor, cytoplasmic mediator activity +


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-aadvanced glycation end-product receptor activity
                                        is-aaryl hydrocarbon receptor activity
                                        is-aauxin receptor activity
                                        is-abile acid receptor activity +
                                        is-acalcitriol receptor activity
                                        is-acoreceptor activity +
                                        is-adiuretic hormone receptor activity
                                        is-aethylene receptor activity +
                                        is-ahigh molecular weight B cell growth factor receptor activity
                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                        is-ajuvenile hormone receptor activity
                                        is-aleucokinin receptor activity
                                        is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                        is-aneurotransmitter receptor activity +
                                        is-aneurotrophin receptor activity +
                                        is-apeptide receptor activity +
                                        is-aphorbol ester receptor activity +
                                        is-aphosphorelay sensor kinase activity
                                        is-aphotoreceptor activity +
                                        is-aretinoic acid receptor activity +
                                        is-asignaling pattern recognition receptor activity +
                                        is-asteroid hormone receptor activity +
                                        is-athrombospondin receptor activity
                                        is-athyroid hormone receptor activity
                                        is-atransmembrane signaling receptor activity +
                                        is-aurokinase plasminogen activator receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-aadvanced glycation end-product receptor activity
                                is-aaryl hydrocarbon receptor activity
                                is-aauxin receptor activity
                                is-abile acid receptor activity +
                                is-acalcitriol receptor activity
                                is-acoreceptor activity +
                                is-adiuretic hormone receptor activity
                                is-aethylene receptor activity +
                                is-ahigh molecular weight B cell growth factor receptor activity
                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                is-ajuvenile hormone receptor activity
                                is-aleucokinin receptor activity
                                is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                is-aneurotransmitter receptor activity +
                                is-aneurotrophin receptor activity +
                                is-apeptide receptor activity +
                                is-aphorbol ester receptor activity +
                                is-aphosphorelay sensor kinase activity
                                is-aphotoreceptor activity +
                                is-aretinoic acid receptor activity +
                                is-asignaling pattern recognition receptor activity +
                                is-asteroid hormone receptor activity +
                                is-athrombospondin receptor activity
                                is-athyroid hormone receptor activity
                                is-atransmembrane signaling receptor activity +
                                is-aurokinase plasminogen activator receptor activity


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-acation channel activity
                                                                is-acalcium channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-adivalent inorganic cation transmembrane transporter activity
                                                                        is-acalcium ion transmembrane transporter activity
                                                                                is-acalcium channel activity
                                                                                        is-acalcium-release channel activity
                                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-ametal ion transmembrane transporter activity
                                                                        is-acalcium ion transmembrane transporter activity
                                                                                is-acalcium channel activity
                                                                                        is-acalcium-release channel activity
                                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aion channel activity
                                                        is-acation channel activity
                                                                is-acalcium channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-acalcium-release channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-aintracellular ligand-gated ion channel activity
                                                                        is-aATP-binding and phosphorylation-dependent chloride channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular cyclic nucleotide activated cation channel activity +
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-asubstrate-specific channel activity
                                                is-aion channel activity
                                                        is-acation channel activity
                                                                is-acalcium channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-asubstrate-specific channel activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-acalcium-release channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-asubstrate-specific transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-asubstrate-specific channel activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-aintracellular ligand-gated ion channel activity
                                                                        is-aATP-binding and phosphorylation-dependent chloride channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular cyclic nucleotide activated cation channel activity +
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-apassive transmembrane transporter activity
                                        is-achannel activity
                                                is-agated channel activity
                                                        is-aligand-gated channel activity
                                                                is-aligand-gated ion channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-apassive transmembrane transporter activity
                                        is-achannel activity
                                                is-agated channel activity
                                                        is-aligand-gated channel activity
                                                                is-aligand-gated ion channel activity
                                                                        is-aintracellular ligand-gated ion channel activity
                                                                                is-aATP-binding and phosphorylation-dependent chloride channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular cyclic nucleotide activated cation channel activity +
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-apassive transmembrane transporter activity
                                        is-achannel activity
                                                is-asubstrate-specific channel activity
                                                        is-aion channel activity
                                                                is-acation channel activity
                                                                        is-acalcium channel activity
                                                                                is-acalcium-release channel activity
                                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-apassive transmembrane transporter activity
                                        is-achannel activity
                                                is-asubstrate-specific channel activity
                                                        is-aion channel activity
                                                                is-aligand-gated ion channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-apassive transmembrane transporter activity
                                        is-achannel activity
                                                is-asubstrate-specific channel activity
                                                        is-aion channel activity
                                                                is-aligand-gated ion channel activity
                                                                        is-aintracellular ligand-gated ion channel activity
                                                                                is-aATP-binding and phosphorylation-dependent chloride channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular cyclic nucleotide activated cation channel activity +
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-acation channel activity
                                                                is-acalcium channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-adivalent inorganic cation transmembrane transporter activity
                                                                        is-acalcium ion transmembrane transporter activity
                                                                                is-acalcium channel activity
                                                                                        is-acalcium-release channel activity
                                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-acation transmembrane transporter activity
                                                        is-ainorganic cation transmembrane transporter activity
                                                                is-ametal ion transmembrane transporter activity
                                                                        is-acalcium ion transmembrane transporter activity
                                                                                is-acalcium channel activity
                                                                                        is-acalcium-release channel activity
                                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aion channel activity
                                                        is-acation channel activity
                                                                is-acalcium channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-acalcium-release channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-aion transmembrane transporter activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-aintracellular ligand-gated ion channel activity
                                                                        is-aATP-binding and phosphorylation-dependent chloride channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular cyclic nucleotide activated cation channel activity +
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-asubstrate-specific channel activity
                                                is-aion channel activity
                                                        is-acation channel activity
                                                                is-acalcium channel activity
                                                                        is-acalcium-release channel activity
                                                                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                                is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-asubstrate-specific channel activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-acalcium-release channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular ligand-gated calcium channel activity +


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-asubstrate-specific transmembrane transporter activity
                                        is-asubstrate-specific channel activity
                                                is-aion channel activity
                                                        is-aligand-gated ion channel activity
                                                                is-aintracellular ligand-gated ion channel activity
                                                                        is-aATP-binding and phosphorylation-dependent chloride channel activity
                                                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220] (3 genes, 7 annotations)
                                                                        is-aintracellular cyclic nucleotide activated cation channel activity +
                                                                        is-aintracellular ligand-gated calcium channel activity +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory