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Gene Ontology Browser
Term Detail
GO term:epidermal growth factor-activated receptor activity
Synonym: EGFR
Synonym: EGF receptor activity
Synonym: epidermal growth factor receptor activity
Synonym: TGF-alpha receptor activity
Synonym: transforming growth factor-alpha receptor activity
GO id:GO:0005006
Definition:Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
CommentsNote that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-aprotein tyrosine kinase activity
                                                                is-atransmembrane receptor protein tyrosine kinase activity
                                                                        is-aboss receptor activity
                                                                        is-abrain-derived neurotrophic factor-activated receptor activity
                                                                        is-aephrin receptor activity +
                                                                        is-aepidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)
                                                                                is-agurken-activated receptor activity
                                                                        is-afibroblast growth factor-activated receptor activity
                                                                        is-ahepatocyte growth factor-activated receptor activity
                                                                        is-ainsulin-activated receptor activity
                                                                        is-ainsulin-like growth factor-activated receptor activity
                                                                        is-amacrophage colony-stimulating factor receptor activity
                                                                        is-aplacental growth factor-activated receptor activity
                                                                        is-aplatelet-derived growth factor-activated receptor activity +
                                                                        is-aprotein tyrosine kinase collagen receptor activity
                                                                        is-astem cell factor receptor activity
                                                                        is-avascular endothelial growth factor-activated receptor activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-atransmembrane receptor protein kinase activity
                                                                is-atransmembrane receptor protein tyrosine kinase activity
                                                                        is-aboss receptor activity
                                                                        is-abrain-derived neurotrophic factor-activated receptor activity
                                                                        is-aephrin receptor activity +
                                                                        is-aepidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)
                                                                                is-agurken-activated receptor activity
                                                                        is-afibroblast growth factor-activated receptor activity
                                                                        is-ahepatocyte growth factor-activated receptor activity
                                                                        is-ainsulin-activated receptor activity
                                                                        is-ainsulin-like growth factor-activated receptor activity
                                                                        is-amacrophage colony-stimulating factor receptor activity
                                                                        is-aplacental growth factor-activated receptor activity
                                                                        is-aplatelet-derived growth factor-activated receptor activity +
                                                                        is-aprotein tyrosine kinase collagen receptor activity
                                                                        is-astem cell factor receptor activity
                                                                        is-avascular endothelial growth factor-activated receptor activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-aprotein tyrosine kinase activity
                                                                is-atransmembrane receptor protein tyrosine kinase activity
                                                                        is-aboss receptor activity
                                                                        is-abrain-derived neurotrophic factor-activated receptor activity
                                                                        is-aephrin receptor activity +
                                                                        is-aepidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)
                                                                                is-agurken-activated receptor activity
                                                                        is-afibroblast growth factor-activated receptor activity
                                                                        is-ahepatocyte growth factor-activated receptor activity
                                                                        is-ainsulin-activated receptor activity
                                                                        is-ainsulin-like growth factor-activated receptor activity
                                                                        is-amacrophage colony-stimulating factor receptor activity
                                                                        is-aplacental growth factor-activated receptor activity
                                                                        is-aplatelet-derived growth factor-activated receptor activity +
                                                                        is-aprotein tyrosine kinase collagen receptor activity
                                                                        is-astem cell factor receptor activity
                                                                        is-avascular endothelial growth factor-activated receptor activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-atransmembrane receptor protein kinase activity
                                                                is-atransmembrane receptor protein tyrosine kinase activity
                                                                        is-aboss receptor activity
                                                                        is-abrain-derived neurotrophic factor-activated receptor activity
                                                                        is-aephrin receptor activity +
                                                                        is-aepidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)
                                                                                is-agurken-activated receptor activity
                                                                        is-afibroblast growth factor-activated receptor activity
                                                                        is-ahepatocyte growth factor-activated receptor activity
                                                                        is-ainsulin-activated receptor activity
                                                                        is-ainsulin-like growth factor-activated receptor activity
                                                                        is-amacrophage colony-stimulating factor receptor activity
                                                                        is-aplacental growth factor-activated receptor activity
                                                                        is-aplatelet-derived growth factor-activated receptor activity +
                                                                        is-aprotein tyrosine kinase collagen receptor activity
                                                                        is-astem cell factor receptor activity
                                                                        is-avascular endothelial growth factor-activated receptor activity +


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-atransmembrane signaling receptor activity
                                                is-atransmembrane receptor protein kinase activity
                                                        is-atransmembrane receptor protein tyrosine kinase activity
                                                                is-aboss receptor activity
                                                                is-abrain-derived neurotrophic factor-activated receptor activity
                                                                is-aephrin receptor activity +
                                                                is-aepidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)
                                                                        is-agurken-activated receptor activity
                                                                is-afibroblast growth factor-activated receptor activity
                                                                is-ahepatocyte growth factor-activated receptor activity
                                                                is-ainsulin-activated receptor activity
                                                                is-ainsulin-like growth factor-activated receptor activity
                                                                is-amacrophage colony-stimulating factor receptor activity
                                                                is-aplacental growth factor-activated receptor activity
                                                                is-aplatelet-derived growth factor-activated receptor activity +
                                                                is-aprotein tyrosine kinase collagen receptor activity
                                                                is-astem cell factor receptor activity
                                                                is-avascular endothelial growth factor-activated receptor activity +


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-atransmembrane signaling receptor activity
                                        is-atransmembrane receptor protein kinase activity
                                                is-atransmembrane receptor protein tyrosine kinase activity
                                                        is-aboss receptor activity
                                                        is-abrain-derived neurotrophic factor-activated receptor activity
                                                        is-aephrin receptor activity +
                                                        is-aepidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)
                                                                is-agurken-activated receptor activity
                                                        is-afibroblast growth factor-activated receptor activity
                                                        is-ahepatocyte growth factor-activated receptor activity
                                                        is-ainsulin-activated receptor activity
                                                        is-ainsulin-like growth factor-activated receptor activity
                                                        is-amacrophage colony-stimulating factor receptor activity
                                                        is-aplacental growth factor-activated receptor activity
                                                        is-aplatelet-derived growth factor-activated receptor activity +
                                                        is-aprotein tyrosine kinase collagen receptor activity
                                                        is-astem cell factor receptor activity
                                                        is-avascular endothelial growth factor-activated receptor activity +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory