| GO term: | epidermal growth factor-activated receptor activity |
| Synonym: | EGFR |
| Synonym: | EGF receptor activity |
| Synonym: | epidermal growth factor receptor activity |
| Synonym: | TGF-alpha receptor activity |
| Synonym: | transforming growth factor-alpha receptor activity |
| GO id: | GO:0005006 |
| Definition: | Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| Comments | Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. |
| Number of paths to term: | 6 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupskinase activityprotein kinase activityprotein tyrosine kinase activitytransmembrane receptor protein tyrosine kinase activityboss receptor activitybrain-derived neurotrophic factor-activated receptor activityephrin receptor activity +epidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)gurken-activated receptor activityfibroblast growth factor-activated receptor activityhepatocyte growth factor-activated receptor activityinsulin-activated receptor activityinsulin-like growth factor-activated receptor activitymacrophage colony-stimulating factor receptor activityplacental growth factor-activated receptor activityplatelet-derived growth factor-activated receptor activity +protein tyrosine kinase collagen receptor activitystem cell factor receptor activityvascular endothelial growth factor-activated receptor activity +molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupskinase activityprotein kinase activitytransmembrane receptor protein kinase activitytransmembrane receptor protein tyrosine kinase activityboss receptor activitybrain-derived neurotrophic factor-activated receptor activityephrin receptor activity +epidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)gurken-activated receptor activityfibroblast growth factor-activated receptor activityhepatocyte growth factor-activated receptor activityinsulin-activated receptor activityinsulin-like growth factor-activated receptor activitymacrophage colony-stimulating factor receptor activityplacental growth factor-activated receptor activityplatelet-derived growth factor-activated receptor activity +protein tyrosine kinase collagen receptor activitystem cell factor receptor activityvascular endothelial growth factor-activated receptor activity +molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupsphosphotransferase activity, alcohol group as acceptorprotein kinase activityprotein tyrosine kinase activitytransmembrane receptor protein tyrosine kinase activityboss receptor activitybrain-derived neurotrophic factor-activated receptor activityephrin receptor activity +epidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)gurken-activated receptor activityfibroblast growth factor-activated receptor activityhepatocyte growth factor-activated receptor activityinsulin-activated receptor activityinsulin-like growth factor-activated receptor activitymacrophage colony-stimulating factor receptor activityplacental growth factor-activated receptor activityplatelet-derived growth factor-activated receptor activity +protein tyrosine kinase collagen receptor activitystem cell factor receptor activityvascular endothelial growth factor-activated receptor activity +molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupsphosphotransferase activity, alcohol group as acceptorprotein kinase activitytransmembrane receptor protein kinase activitytransmembrane receptor protein tyrosine kinase activityboss receptor activitybrain-derived neurotrophic factor-activated receptor activityephrin receptor activity +epidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)gurken-activated receptor activityfibroblast growth factor-activated receptor activityhepatocyte growth factor-activated receptor activityinsulin-activated receptor activityinsulin-like growth factor-activated receptor activitymacrophage colony-stimulating factor receptor activityplacental growth factor-activated receptor activityplatelet-derived growth factor-activated receptor activity +protein tyrosine kinase collagen receptor activitystem cell factor receptor activityvascular endothelial growth factor-activated receptor activity +molecular_functionmolecular transducer activitysignal transducer activitysignaling receptor activitytransmembrane signaling receptor activitytransmembrane receptor protein kinase activitytransmembrane receptor protein tyrosine kinase activityboss receptor activitybrain-derived neurotrophic factor-activated receptor activityephrin receptor activity +epidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)gurken-activated receptor activityfibroblast growth factor-activated receptor activityhepatocyte growth factor-activated receptor activityinsulin-activated receptor activityinsulin-like growth factor-activated receptor activitymacrophage colony-stimulating factor receptor activityplacental growth factor-activated receptor activityplatelet-derived growth factor-activated receptor activity +protein tyrosine kinase collagen receptor activitystem cell factor receptor activityvascular endothelial growth factor-activated receptor activity +molecular_functionreceptor activitysignaling receptor activitytransmembrane signaling receptor activitytransmembrane receptor protein kinase activitytransmembrane receptor protein tyrosine kinase activityboss receptor activitybrain-derived neurotrophic factor-activated receptor activityephrin receptor activity +epidermal growth factor-activated receptor activity [GO:0005006] (3 genes, 4 annotations)gurken-activated receptor activityfibroblast growth factor-activated receptor activityhepatocyte growth factor-activated receptor activityinsulin-activated receptor activityinsulin-like growth factor-activated receptor activitymacrophage colony-stimulating factor receptor activityplacental growth factor-activated receptor activityplatelet-derived growth factor-activated receptor activity +protein tyrosine kinase collagen receptor activitystem cell factor receptor activityvascular endothelial growth factor-activated receptor activity +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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