About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:RNA-DNA hybrid ribonuclease activity
Synonym: calf thymus ribonuclease H activity
Synonym: endoribonuclease0 H activity
Synonym: endoribonuclease H
Synonym: endoribonuclease H (calf thymus)
Synonym: hybridase activity
Synonym: hybridase (ribonuclease H)
Synonym: hybrid nuclease activity
Synonym: hybrid ribonuclease activity
Synonym: ribonuclease H1 activity
Synonym: ribonuclease H2 activity
Synonym: ribonuclease H3 activity
Synonym: ribonuclease H activity
Synonym: RNA*DNA hybrid ribonucleotidohydrolase activity
Synonym: RNase H1 activity
Synonym: RNase H2 activity
Synonym: RNase H3 activity
Synonym: RNase H activity
GO id:GO:0004523
Definition:Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
CommentsNote that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-anuclease activity
                                                is-aendonuclease activity
                                                        is-aendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
                                                                is-aendoribonuclease activity, producing 5'-phosphomonoesters
                                                                        is-a3'-tRNA processing endoribonuclease activity
                                                                        is-aapurinic/apyrimidinic endoribonuclease activity
                                                                        is-aendoribonuclease activity, cleaving siRNA-paired mRNA
                                                                        is-aphosphodiesterase decapping endonuclease activity
                                                                        is-aribonuclease [poly-(U)-specific] activity
                                                                        is-aribonuclease III activity +
                                                                        is-aribonuclease IV activity
                                                                        is-aribonuclease IX activity
                                                                        is-aribonuclease M5 activity
                                                                        is-aribonuclease P activity
                                                                        is-aribonuclease P4 activity
                                                                        is-aRNA lariat debranching enzyme activity
                                                                        is-aRNA-DNA hybrid ribonuclease activity [GO:0004523] (4 genes, 5 annotations)


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-anuclease activity
                                                is-aendonuclease activity
                                                        is-aendoribonuclease activity
                                                                is-aendoribonuclease activity, producing 5'-phosphomonoesters
                                                                        is-a3'-tRNA processing endoribonuclease activity
                                                                        is-aapurinic/apyrimidinic endoribonuclease activity
                                                                        is-aendoribonuclease activity, cleaving siRNA-paired mRNA
                                                                        is-aphosphodiesterase decapping endonuclease activity
                                                                        is-aribonuclease [poly-(U)-specific] activity
                                                                        is-aribonuclease III activity +
                                                                        is-aribonuclease IV activity
                                                                        is-aribonuclease IX activity
                                                                        is-aribonuclease M5 activity
                                                                        is-aribonuclease P activity
                                                                        is-aribonuclease P4 activity
                                                                        is-aRNA lariat debranching enzyme activity
                                                                        is-aRNA-DNA hybrid ribonuclease activity [GO:0004523] (4 genes, 5 annotations)


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-anuclease activity
                                                is-aribonuclease activity
                                                        is-aendoribonuclease activity
                                                                is-aendoribonuclease activity, producing 5'-phosphomonoesters
                                                                        is-a3'-tRNA processing endoribonuclease activity
                                                                        is-aapurinic/apyrimidinic endoribonuclease activity
                                                                        is-aendoribonuclease activity, cleaving siRNA-paired mRNA
                                                                        is-aphosphodiesterase decapping endonuclease activity
                                                                        is-aribonuclease [poly-(U)-specific] activity
                                                                        is-aribonuclease III activity +
                                                                        is-aribonuclease IV activity
                                                                        is-aribonuclease IX activity
                                                                        is-aribonuclease M5 activity
                                                                        is-aribonuclease P activity
                                                                        is-aribonuclease P4 activity
                                                                        is-aRNA lariat debranching enzyme activity
                                                                        is-aRNA-DNA hybrid ribonuclease activity [GO:0004523] (4 genes, 5 annotations)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory