About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:nitric-oxide synthase activity
Synonym: endothelium-derived relaxation factor-forming enzyme activity
Synonym: endothelium-derived relaxing factor synthase activity
Synonym: L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
Synonym: NADPH-diaphorase activity
Synonym: nitric oxide synthase activity
Synonym: nitric oxide synthetase activity
Synonym: nitric-oxide synthetase activity
Synonym: NO synthase activity
GO id:GO:0004517
Definition:Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-amonooxygenase activity
                                        is-aoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
                                                is-a(+)-abscisic acid 8'-hydroxylase activity
                                                is-a(+)-menthofuran synthase activity
                                                is-a(-)-menthol monooxygenase activity
                                                is-a(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity
                                                is-a1-hydroxy-2-naphthoate hydroxylase activity
                                                is-a1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
                                                is-a1-methylnaphthalene hydroxylase activity
                                                is-a2,4-dichlorophenol 6-monooxygenase activity
                                                is-a2,6-dihydroxypyridine 3-monooxygenase activity
                                                is-a2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
                                                is-a2-hydroxy-phenylacetate hydroxylase activity
                                                is-a2-hydroxybiphenyl 3-monooxygenase activity
                                                is-a2-hydroxycyclohexanone 2-monooxygenase activity
                                                is-a2-hydroxyisoflavanone synthase activity
                                                is-a2-hydroxyquinoline 8-monooxygenase activity
                                                is-a2-methylnaphthalene hydroxylase activity
                                                is-a2-nitrophenol 2-monooxygenase activity
                                                is-a2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
                                                is-a2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
                                                is-a24-hydroxycholesterol 7alpha-hydroxylase activity
                                                is-a25-hydroxycholesterol 7alpha-hydroxylase activity
                                                is-a27-hydroxycholesterol 7-alpha-monooxygenase activity
                                                is-a3,5-xylenol methylhydroxylase activity
                                                is-a3,9-dihydroxypterocarpan 6a-monooxygenase activity
                                                is-a3-(3-hydroxyphenyl)propionate hydroxylase activity
                                                is-a3-HSA hydroxylase activity
                                                is-a3-hydroxybenzoate 4-monooxygenase activity
                                                is-a3-hydroxybenzoate 6-monooxygenase activity
                                                is-a3-hydroxyindolin-2-one monooxygenase activity
                                                is-a3-hydroxyphenylacetate 6-hydroxylase activity
                                                is-a3-ketosteroid 9-alpha-monooxygenase activity
                                                is-a3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
                                                is-a4'-methoxyisoflavone 2'-hydroxylase activity
                                                is-a4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity
                                                is-a4-aminobenzoate 1-monooxygenase activity
                                                is-a4-chlorobenzaldehyde oxidase activity
                                                is-a4-hydroxyacetophenone monooxygenase activity
                                                is-a4-hydroxybenzoate 1-hydroxylase activity
                                                is-a4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
                                                is-a4-hydroxybenzoate 3-monooxygenase activity
                                                is-a4-hydroxyphenylacetaldehyde oxime monooxygenase activity
                                                is-a4-hydroxyphenylacetate 1-monooxygenase activity
                                                is-a4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity
                                                is-a4-hydroxypyridine-3-hydroxylase activity
                                                is-a4-hydroxyquinoline 3-monooxygenase activity
                                                is-a4-nitrophenol 2-monooxygenase activity
                                                is-a4-nitrophenol 4-monooxygenase activity
                                                is-a5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
                                                is-a5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
                                                is-a6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
                                                is-a6-hydroxynicotinate 3-monooxygenase activity
                                                is-a6-oxocineole dehydrogenase activity
                                                is-a7-deoxyloganin 7-hydroxylase activity
                                                is-a7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
                                                is-a9beta-pimara-7,15-diene oxidase activity
                                                is-aabieta-7,13-dien-18-ol hydroxylase activity
                                                is-aabieta-7,13-diene hydroxylase activity
                                                is-aalbendazole monooxygenase activity
                                                is-aalkene monooxygenase activity
                                                is-aalpha-pinene monooxygenase [NADH] activity
                                                is-aanhydrotetracycline monooxygenase activity
                                                is-aantheraxanthin epoxidase activity
                                                is-aanthranilate 3-monooxygenase (deaminating) activity
                                                is-aanthraniloyl-CoA monooxygenase activity
                                                is-abenzoate 4-monooxygenase activity
                                                is-abenzoyl-CoA 3-monooxygenase activity
                                                is-abisphenol A hydroxylase A activity
                                                is-abranched-chain dodecylbenzene sulfonate monooxygenase activity
                                                is-aC-4 methylsterol oxidase activity
                                                is-acalcidiol 1-monooxygenase activity
                                                is-acarbon disulfide oxygenase activity
                                                is-achlorophenol 4-monooxygenase activity
                                                is-acholest-4-en-3-one 26-monooxygenase activity
                                                is-acholestanetriol 26-monooxygenase activity
                                                is-acholesterol 24-hydroxylase activity
                                                is-acholesterol 7-alpha-monooxygenase activity
                                                is-acyclohexanone monooxygenase activity
                                                is-acyclopentanone monooxygenase activity
                                                is-adeoxysarpagine hydroxylase activity
                                                is-adibenzothiophene monooxygenase activity
                                                is-adihydrochelirubine 12-monooxygenase activity
                                                is-adihydrosanguinarine 10-monooxygenase activity
                                                is-adimethyl sulfide monooxygenase activity
                                                is-aent-7-alpha-hydroxykaurenoate oxidase activity
                                                is-aent-cassa-12,15-diene 11-hydroxylase activity
                                                is-aent-isokaurene C2-hydroxylase activity
                                                is-aent-kaur-16-en-19-al oxidase activity
                                                is-aent-kaur-16-en-19-ol oxidase activity
                                                is-aent-kaurene oxidase activity
                                                is-aent-kaurenoate oxidase activity
                                                is-aflavonoid 3',5'-hydroxylase activity
                                                is-aflavonoid 3'-monooxygenase activity
                                                is-agibberellin 12-aldehyde oxidase activity
                                                is-aglyceollin synthase activity
                                                is-ahydroxyphenylacetonitrile 2-monooxygenase activity
                                                is-aimidazoleacetate 4-monooxygenase activity
                                                is-aindole-2-monooxygenase activity
                                                is-aindolin-2-one monooxygenase activity
                                                is-aisobutylamine N-hydroxylase activity
                                                is-aisoflavone 2'-hydroxylase activity
                                                is-aisoflavone 3'-hydroxylase activity
                                                is-aketosteroid monooxygenase activity
                                                is-akynurenine 3-monooxygenase activity
                                                is-aL-lysine 6-monooxygenase (NADPH) activity
                                                is-aL-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
                                                is-aL-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
                                                is-aleukotriene-B4 20-monooxygenase activity
                                                is-aleukotriene-E4 20-monooxygenase activity
                                                is-alicodione synthase activity
                                                is-alimonene monooxygenase activity +
                                                is-alithocholate 6beta-hydroxylase activity
                                                is-amagnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
                                                is-amelilotate 3-monooxygenase activity
                                                is-amethane monooxygenase activity
                                                is-amethanesulfonate monooxygenase activity
                                                is-amethyltetrahydroprotoberberine 14-monooxygenase activity
                                                is-aN,N-dimethylaniline monooxygenase activity
                                                is-aN-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
                                                is-aN-methylcoclaurine 3'-monooxygenase activity
                                                is-anitric-oxide synthase activity [GO:0004517] (3 genes, 6 annotations)
                                                is-aorcinol 2-monooxygenase activity
                                                is-apentachlorophenol monooxygenase activity
                                                is-aphenanthrene 1,2-monooxygenase activity
                                                is-aphenanthrene 3,4-monooxygenase activity
                                                is-aphenanthrene 9,10-monooxygenase activity
                                                is-aphenol 2-monooxygenase activity
                                                is-aphenylacetate hydroxylase activity
                                                is-aphenylacetone monooxygenase activity
                                                is-aphenylacetyl-CoA 1,2-epoxidase activity
                                                is-aphosphatidylcholine 12-monooxygenase activity
                                                is-aprecorrin-3B synthase activity
                                                is-aprotopine 6-monooxygenase activity
                                                is-aquestin monooxygenase activity
                                                is-aquinine 3-monooxygenase activity
                                                is-asalicylate 1-monooxygenase activity
                                                is-asalicylate 5-hydroxylase activity
                                                is-asenecionine N-oxygenase activity
                                                is-asqualene monooxygenase activity
                                                is-asterol 14-demethylase activity
                                                is-astyrene monooxygenase activity
                                                is-atabersonine 16-hydroxylase activity
                                                is-ataurochenodeoxycholate 6alpha-hydroxylase activity
                                                is-ataxane 10-beta-hydroxylase activity
                                                is-ataxane 13-alpha-hydroxylase activity
                                                is-ataxifolin 8-monooxygenase activity
                                                is-ataxoid 14-beta-hydroxylase activity
                                                is-ataxoid 7beta-hydroxylase activity
                                                is-atetrahydrofuran hydroxylase activity
                                                is-atocopherol omega-hydroxylase activity +
                                                is-atocotrienol omega-hydroxylase activity
                                                is-atoluene 2-monooxygenase activity
                                                is-atoluene 3-monooxygenase activity
                                                is-atoluene 4-monooxygenase activity
                                                is-atoluene-4-sulfonate monooxygenase activity
                                                is-atoluene-sulfonate methyl-monooxygenase activity
                                                is-atrans-cinnamate 2-monooxygenase activity
                                                is-atrans-cinnamate 4-monooxygenase activity
                                                is-atri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity +
                                                is-atri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity +
                                                is-atrimethylamine monooxygenase activity
                                                is-atyrosine N-monooxygenase activity
                                                is-avanillate monooxygenase activity
                                                is-avinorine hydroxylase activity
                                                is-axylene monooxygenase activity
                                                is-azeaxanthin epoxidase [overall] activity
                                                is-azeaxanthin epoxidase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
                                        is-aoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
                                                is-a(+)-abscisic acid 8'-hydroxylase activity
                                                is-a(+)-menthofuran synthase activity
                                                is-a(-)-menthol monooxygenase activity
                                                is-a(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity
                                                is-a1-hydroxy-2-naphthoate hydroxylase activity
                                                is-a1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
                                                is-a1-methylnaphthalene hydroxylase activity
                                                is-a2,4-dichlorophenol 6-monooxygenase activity
                                                is-a2,6-dihydroxypyridine 3-monooxygenase activity
                                                is-a2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
                                                is-a2-hydroxy-phenylacetate hydroxylase activity
                                                is-a2-hydroxybiphenyl 3-monooxygenase activity
                                                is-a2-hydroxycyclohexanone 2-monooxygenase activity
                                                is-a2-hydroxyisoflavanone synthase activity
                                                is-a2-hydroxyquinoline 8-monooxygenase activity
                                                is-a2-methylnaphthalene hydroxylase activity
                                                is-a2-nitrophenol 2-monooxygenase activity
                                                is-a2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
                                                is-a2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
                                                is-a24-hydroxycholesterol 7alpha-hydroxylase activity
                                                is-a25-hydroxycholesterol 7alpha-hydroxylase activity
                                                is-a27-hydroxycholesterol 7-alpha-monooxygenase activity
                                                is-a3,5-xylenol methylhydroxylase activity
                                                is-a3,9-dihydroxypterocarpan 6a-monooxygenase activity
                                                is-a3-(3-hydroxyphenyl)propionate hydroxylase activity
                                                is-a3-HSA hydroxylase activity
                                                is-a3-hydroxybenzoate 4-monooxygenase activity
                                                is-a3-hydroxybenzoate 6-monooxygenase activity
                                                is-a3-hydroxyindolin-2-one monooxygenase activity
                                                is-a3-hydroxyphenylacetate 6-hydroxylase activity
                                                is-a3-ketosteroid 9-alpha-monooxygenase activity
                                                is-a3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
                                                is-a4'-methoxyisoflavone 2'-hydroxylase activity
                                                is-a4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity
                                                is-a4-aminobenzoate 1-monooxygenase activity
                                                is-a4-chlorobenzaldehyde oxidase activity
                                                is-a4-hydroxyacetophenone monooxygenase activity
                                                is-a4-hydroxybenzoate 1-hydroxylase activity
                                                is-a4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
                                                is-a4-hydroxybenzoate 3-monooxygenase activity
                                                is-a4-hydroxyphenylacetaldehyde oxime monooxygenase activity
                                                is-a4-hydroxyphenylacetate 1-monooxygenase activity
                                                is-a4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity
                                                is-a4-hydroxypyridine-3-hydroxylase activity
                                                is-a4-hydroxyquinoline 3-monooxygenase activity
                                                is-a4-nitrophenol 2-monooxygenase activity
                                                is-a4-nitrophenol 4-monooxygenase activity
                                                is-a5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
                                                is-a5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
                                                is-a6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
                                                is-a6-hydroxynicotinate 3-monooxygenase activity
                                                is-a6-oxocineole dehydrogenase activity
                                                is-a7-deoxyloganin 7-hydroxylase activity
                                                is-a7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
                                                is-a9beta-pimara-7,15-diene oxidase activity
                                                is-aabieta-7,13-dien-18-ol hydroxylase activity
                                                is-aabieta-7,13-diene hydroxylase activity
                                                is-aalbendazole monooxygenase activity
                                                is-aalkene monooxygenase activity
                                                is-aalpha-pinene monooxygenase [NADH] activity
                                                is-aanhydrotetracycline monooxygenase activity
                                                is-aantheraxanthin epoxidase activity
                                                is-aanthranilate 3-monooxygenase (deaminating) activity
                                                is-aanthraniloyl-CoA monooxygenase activity
                                                is-abenzoate 4-monooxygenase activity
                                                is-abenzoyl-CoA 3-monooxygenase activity
                                                is-abisphenol A hydroxylase A activity
                                                is-abranched-chain dodecylbenzene sulfonate monooxygenase activity
                                                is-aC-4 methylsterol oxidase activity
                                                is-acalcidiol 1-monooxygenase activity
                                                is-acarbon disulfide oxygenase activity
                                                is-achlorophenol 4-monooxygenase activity
                                                is-acholest-4-en-3-one 26-monooxygenase activity
                                                is-acholestanetriol 26-monooxygenase activity
                                                is-acholesterol 24-hydroxylase activity
                                                is-acholesterol 7-alpha-monooxygenase activity
                                                is-acyclohexanone monooxygenase activity
                                                is-acyclopentanone monooxygenase activity
                                                is-adeoxysarpagine hydroxylase activity
                                                is-adibenzothiophene monooxygenase activity
                                                is-adihydrochelirubine 12-monooxygenase activity
                                                is-adihydrosanguinarine 10-monooxygenase activity
                                                is-adimethyl sulfide monooxygenase activity
                                                is-aent-7-alpha-hydroxykaurenoate oxidase activity
                                                is-aent-cassa-12,15-diene 11-hydroxylase activity
                                                is-aent-isokaurene C2-hydroxylase activity
                                                is-aent-kaur-16-en-19-al oxidase activity
                                                is-aent-kaur-16-en-19-ol oxidase activity
                                                is-aent-kaurene oxidase activity
                                                is-aent-kaurenoate oxidase activity
                                                is-aflavonoid 3',5'-hydroxylase activity
                                                is-aflavonoid 3'-monooxygenase activity
                                                is-agibberellin 12-aldehyde oxidase activity
                                                is-aglyceollin synthase activity
                                                is-ahydroxyphenylacetonitrile 2-monooxygenase activity
                                                is-aimidazoleacetate 4-monooxygenase activity
                                                is-aindole-2-monooxygenase activity
                                                is-aindolin-2-one monooxygenase activity
                                                is-aisobutylamine N-hydroxylase activity
                                                is-aisoflavone 2'-hydroxylase activity
                                                is-aisoflavone 3'-hydroxylase activity
                                                is-aketosteroid monooxygenase activity
                                                is-akynurenine 3-monooxygenase activity
                                                is-aL-lysine 6-monooxygenase (NADPH) activity
                                                is-aL-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
                                                is-aL-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
                                                is-aleukotriene-B4 20-monooxygenase activity
                                                is-aleukotriene-E4 20-monooxygenase activity
                                                is-alicodione synthase activity
                                                is-alimonene monooxygenase activity +
                                                is-alithocholate 6beta-hydroxylase activity
                                                is-amagnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
                                                is-amelilotate 3-monooxygenase activity
                                                is-amethane monooxygenase activity
                                                is-amethanesulfonate monooxygenase activity
                                                is-amethyltetrahydroprotoberberine 14-monooxygenase activity
                                                is-aN,N-dimethylaniline monooxygenase activity
                                                is-aN-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
                                                is-aN-methylcoclaurine 3'-monooxygenase activity
                                                is-anitric-oxide synthase activity [GO:0004517] (3 genes, 6 annotations)
                                                is-aorcinol 2-monooxygenase activity
                                                is-apentachlorophenol monooxygenase activity
                                                is-aphenanthrene 1,2-monooxygenase activity
                                                is-aphenanthrene 3,4-monooxygenase activity
                                                is-aphenanthrene 9,10-monooxygenase activity
                                                is-aphenol 2-monooxygenase activity
                                                is-aphenylacetate hydroxylase activity
                                                is-aphenylacetone monooxygenase activity
                                                is-aphenylacetyl-CoA 1,2-epoxidase activity
                                                is-aphosphatidylcholine 12-monooxygenase activity
                                                is-aprecorrin-3B synthase activity
                                                is-aprotopine 6-monooxygenase activity
                                                is-aquestin monooxygenase activity
                                                is-aquinine 3-monooxygenase activity
                                                is-asalicylate 1-monooxygenase activity
                                                is-asalicylate 5-hydroxylase activity
                                                is-asenecionine N-oxygenase activity
                                                is-asqualene monooxygenase activity
                                                is-asterol 14-demethylase activity
                                                is-astyrene monooxygenase activity
                                                is-atabersonine 16-hydroxylase activity
                                                is-ataurochenodeoxycholate 6alpha-hydroxylase activity
                                                is-ataxane 10-beta-hydroxylase activity
                                                is-ataxane 13-alpha-hydroxylase activity
                                                is-ataxifolin 8-monooxygenase activity
                                                is-ataxoid 14-beta-hydroxylase activity
                                                is-ataxoid 7beta-hydroxylase activity
                                                is-atetrahydrofuran hydroxylase activity
                                                is-atocopherol omega-hydroxylase activity +
                                                is-atocotrienol omega-hydroxylase activity
                                                is-atoluene 2-monooxygenase activity
                                                is-atoluene 3-monooxygenase activity
                                                is-atoluene 4-monooxygenase activity
                                                is-atoluene-4-sulfonate monooxygenase activity
                                                is-atoluene-sulfonate methyl-monooxygenase activity
                                                is-atrans-cinnamate 2-monooxygenase activity
                                                is-atrans-cinnamate 4-monooxygenase activity
                                                is-atri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity +
                                                is-atri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity +
                                                is-atrimethylamine monooxygenase activity
                                                is-atyrosine N-monooxygenase activity
                                                is-avanillate monooxygenase activity
                                                is-avinorine hydroxylase activity
                                                is-axylene monooxygenase activity
                                                is-azeaxanthin epoxidase [overall] activity
                                                is-azeaxanthin epoxidase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory