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Term Detail
GO term:homogentisate 1,2-dioxygenase activity
Synonym: homogentisate dioxygenase activity
Synonym: homogentisate oxidase activity
Synonym: homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
Synonym: homogentisate oxygenase activity
Synonym: homogentisic acid oxidase activity
Synonym: homogentisic acid oxygenase activity
Synonym: homogentisicase activity
Synonym: homogentisic oxygenase activity
GO id:GO:0004411
Definition:Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-adioxygenase activity
                                        is-aoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
                                                is-a1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
                                                is-a1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
                                                is-a1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
                                                is-a1-hydroxy-2-naphthoate 1,2-dioxygenase activity
                                                is-a2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
                                                is-a2,2',3-trihydroxybiphenyl dioxygenase activity
                                                is-a2,3-dihydroxy DDT 1,2-dioxygenase activity
                                                is-a2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
                                                is-a2,3-dihydroxy-p-cumate dioxygenase activity
                                                is-a2,3-dihydroxybenzoate 2,3-dioxygenase activity
                                                is-a2,3-dihydroxybenzoate 3,4-dioxygenase activity
                                                is-a2,3-dihydroxybiphenyl 1,2-dioxygenase activity
                                                is-a2,3-dihydroxydiphenyl ether dioxygenase activity
                                                is-a2,3-dihydroxyindole 2,3-dioxygenase activity
                                                is-a2,4'-dihydroxyacetophenone dioxygenase activity
                                                is-a2,5-dihydroxypyridine 5,6-dioxygenase activity
                                                is-a2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
                                                is-a2-aminophenol 1,6-dioxygenase activity
                                                is-a2-mercaptobenzothiazole dioxygenase activity
                                                is-a3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
                                                is-a3,4-dihydroxyphenanthrene dioxygenase activity
                                                is-a3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
                                                is-a3,5-dichlorocatechol 1,2-dioxygenase activity
                                                is-a3-carboxyethylcatechol 2,3-dioxygenase activity
                                                is-a3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
                                                is-a3-hydroxy-2-naphthoate 2,3-dioxygenase activity
                                                is-a3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
                                                is-a3-hydroxyanthranilate 3,4-dioxygenase activity
                                                is-a4,5-dihydroxybenzo(a)pyrene dioxygenase activity
                                                is-a4,5-dihydroxypyrene dioxygenase activity
                                                is-a4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
                                                is-a4-hydroxycatechol 1,2-dioxygenase activity
                                                is-a4-hydroxymandelate synthase activity
                                                is-a4-hydroxyphenylpyruvate dioxygenase activity
                                                is-a5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
                                                is-a5-aminosalicylate dioxygenase activity
                                                is-a7,8-dihydroxy benzo(a)pyrene dioxygenase activity
                                                is-a7,8-dihydroxykynurenate 8,8a-dioxygenase activity
                                                is-a9,10-dihydroxybenzo(a)pyrene dioxygenase activity
                                                is-aacetylacetone-cleaving enzyme activity
                                                is-aacireductone dioxygenase (Ni2+-requiring) activity
                                                is-aacireductone dioxygenase [iron(II)-requiring] activity
                                                is-aarachidonate 12-lipoxygenase activity
                                                is-aarachidonate 15-lipoxygenase activity
                                                is-aarachidonate 5-lipoxygenase activity
                                                is-aarachidonate 8(R)-lipoxygenase activity
                                                is-aarachidonate 8(S)-lipoxygenase activity
                                                is-abenzo(a)pyrene 11,12-dioxygenase activity
                                                is-abenzo(a)pyrene 4,5-dioxygenase activity
                                                is-abenzo(a)pyrene 7,8-dioxygenase activity
                                                is-abenzo(a)pyrene 9,10-dioxygenase activity
                                                is-abeta-carotene 15,15'-monooxygenase activity
                                                is-abiphenyl-2,3-diol 1,2-dioxygenase activity
                                                is-acaffeate 3,4-dioxygenase activity
                                                is-acarbazole 1,9a-dioxygenase activity
                                                is-acarotenoid dioxygenase activity +
                                                is-acatechol dioxygenase activity +
                                                is-achloridazon-catechol dioxygenase activity
                                                is-achlorite O2-lyase activity
                                                is-achlorocatechol 1,2-dioxygenase activity
                                                is-acysteamine dioxygenase activity
                                                is-acysteine dioxygenase activity
                                                is-adihydroxydibenzothiophene dioxygenase activity
                                                is-adihydroxyfluorene dioxygenase activity +
                                                is-adiphenyl ether 1,2-dioxygenase activity
                                                is-agallate dioxygenase activity
                                                is-agentisate 1,2-dioxygenase activity
                                                is-ahomogentisate 1,2-dioxygenase activity [GO:0004411] (1 genes, 1 annotations)
                                                is-ahydroquinone 1,2-dioxygenase activity
                                                is-ahydroxyquinol 1,2-dioxygenase activity
                                                is-aindole 2,3-dioxygenase activity
                                                is-aindoleamine 2,3-dioxygenase activity
                                                is-alignostilbene alpha beta-dioxygenase activity
                                                is-alinoleate 11-lipoxygenase activity
                                                is-alinoleate 13S-lipoxygenase activity
                                                is-alinoleate 8R-lipoxygenase activity
                                                is-alinoleate 9S-lipoxygenase activity
                                                is-alinoleate diol synthase activity
                                                is-ap-cumate 2,3-dioxygenase activity
                                                is-apeptide-tryptophan 2,3-dioxygenase activity
                                                is-aphenanthrene dioxygenase activity
                                                is-aphenanthrene-4-carboxylate dioxygenase activity
                                                is-aprotocatechuate 3,4-dioxygenase activity
                                                is-aprotocatechuate 3,4-dioxygenase type II activity
                                                is-aprotocatechuate 4,5-dioxygenase activity
                                                is-apyrene dioxygenase activity
                                                is-apyridine-3,4-diol dioxygenase activity
                                                is-apyrogallol 1,2-oxygenase activity
                                                is-aquercetin 2,3-dioxygenase activity
                                                is-astizolobate synthase activity
                                                is-astizolobinate synthase activity
                                                is-astyrene dioxygenase activity
                                                is-asulfur dioxygenase activity
                                                is-asulfur oxygenase/reductase activity
                                                is-atetrachlorobenzene dioxygenase activity
                                                is-atryptophan 2,3-dioxygenase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
                                        is-aoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
                                                is-a1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
                                                is-a1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
                                                is-a1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
                                                is-a1-hydroxy-2-naphthoate 1,2-dioxygenase activity
                                                is-a2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
                                                is-a2,2',3-trihydroxybiphenyl dioxygenase activity
                                                is-a2,3-dihydroxy DDT 1,2-dioxygenase activity
                                                is-a2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
                                                is-a2,3-dihydroxy-p-cumate dioxygenase activity
                                                is-a2,3-dihydroxybenzoate 2,3-dioxygenase activity
                                                is-a2,3-dihydroxybenzoate 3,4-dioxygenase activity
                                                is-a2,3-dihydroxybiphenyl 1,2-dioxygenase activity
                                                is-a2,3-dihydroxydiphenyl ether dioxygenase activity
                                                is-a2,3-dihydroxyindole 2,3-dioxygenase activity
                                                is-a2,4'-dihydroxyacetophenone dioxygenase activity
                                                is-a2,5-dihydroxypyridine 5,6-dioxygenase activity
                                                is-a2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
                                                is-a2-aminophenol 1,6-dioxygenase activity
                                                is-a2-mercaptobenzothiazole dioxygenase activity
                                                is-a3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
                                                is-a3,4-dihydroxyphenanthrene dioxygenase activity
                                                is-a3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
                                                is-a3,5-dichlorocatechol 1,2-dioxygenase activity
                                                is-a3-carboxyethylcatechol 2,3-dioxygenase activity
                                                is-a3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
                                                is-a3-hydroxy-2-naphthoate 2,3-dioxygenase activity
                                                is-a3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
                                                is-a3-hydroxyanthranilate 3,4-dioxygenase activity
                                                is-a4,5-dihydroxybenzo(a)pyrene dioxygenase activity
                                                is-a4,5-dihydroxypyrene dioxygenase activity
                                                is-a4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
                                                is-a4-hydroxycatechol 1,2-dioxygenase activity
                                                is-a4-hydroxymandelate synthase activity
                                                is-a4-hydroxyphenylpyruvate dioxygenase activity
                                                is-a5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
                                                is-a5-aminosalicylate dioxygenase activity
                                                is-a7,8-dihydroxy benzo(a)pyrene dioxygenase activity
                                                is-a7,8-dihydroxykynurenate 8,8a-dioxygenase activity
                                                is-a9,10-dihydroxybenzo(a)pyrene dioxygenase activity
                                                is-aacetylacetone-cleaving enzyme activity
                                                is-aacireductone dioxygenase (Ni2+-requiring) activity
                                                is-aacireductone dioxygenase [iron(II)-requiring] activity
                                                is-aarachidonate 12-lipoxygenase activity
                                                is-aarachidonate 15-lipoxygenase activity
                                                is-aarachidonate 5-lipoxygenase activity
                                                is-aarachidonate 8(R)-lipoxygenase activity
                                                is-aarachidonate 8(S)-lipoxygenase activity
                                                is-abenzo(a)pyrene 11,12-dioxygenase activity
                                                is-abenzo(a)pyrene 4,5-dioxygenase activity
                                                is-abenzo(a)pyrene 7,8-dioxygenase activity
                                                is-abenzo(a)pyrene 9,10-dioxygenase activity
                                                is-abeta-carotene 15,15'-monooxygenase activity
                                                is-abiphenyl-2,3-diol 1,2-dioxygenase activity
                                                is-acaffeate 3,4-dioxygenase activity
                                                is-acarbazole 1,9a-dioxygenase activity
                                                is-acarotenoid dioxygenase activity +
                                                is-acatechol dioxygenase activity +
                                                is-achloridazon-catechol dioxygenase activity
                                                is-achlorite O2-lyase activity
                                                is-achlorocatechol 1,2-dioxygenase activity
                                                is-acysteamine dioxygenase activity
                                                is-acysteine dioxygenase activity
                                                is-adihydroxydibenzothiophene dioxygenase activity
                                                is-adihydroxyfluorene dioxygenase activity +
                                                is-adiphenyl ether 1,2-dioxygenase activity
                                                is-agallate dioxygenase activity
                                                is-agentisate 1,2-dioxygenase activity
                                                is-ahomogentisate 1,2-dioxygenase activity [GO:0004411] (1 genes, 1 annotations)
                                                is-ahydroquinone 1,2-dioxygenase activity
                                                is-ahydroxyquinol 1,2-dioxygenase activity
                                                is-aindole 2,3-dioxygenase activity
                                                is-aindoleamine 2,3-dioxygenase activity
                                                is-alignostilbene alpha beta-dioxygenase activity
                                                is-alinoleate 11-lipoxygenase activity
                                                is-alinoleate 13S-lipoxygenase activity
                                                is-alinoleate 8R-lipoxygenase activity
                                                is-alinoleate 9S-lipoxygenase activity
                                                is-alinoleate diol synthase activity
                                                is-ap-cumate 2,3-dioxygenase activity
                                                is-apeptide-tryptophan 2,3-dioxygenase activity
                                                is-aphenanthrene dioxygenase activity
                                                is-aphenanthrene-4-carboxylate dioxygenase activity
                                                is-aprotocatechuate 3,4-dioxygenase activity
                                                is-aprotocatechuate 3,4-dioxygenase type II activity
                                                is-aprotocatechuate 4,5-dioxygenase activity
                                                is-apyrene dioxygenase activity
                                                is-apyridine-3,4-diol dioxygenase activity
                                                is-apyrogallol 1,2-oxygenase activity
                                                is-aquercetin 2,3-dioxygenase activity
                                                is-astizolobate synthase activity
                                                is-astizolobinate synthase activity
                                                is-astyrene dioxygenase activity
                                                is-asulfur dioxygenase activity
                                                is-asulfur oxygenase/reductase activity
                                                is-atetrachlorobenzene dioxygenase activity
                                                is-atryptophan 2,3-dioxygenase activity


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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory