MGI 5.13 - Gene Ontology Browser

Gene Ontology Browser
Term Detail

GO term:	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
Synonym:	GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
Synonym:	GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
Synonym:	GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
Synonym:	glycolipid 2-alpha-mannosyltransferase activity
Synonym:	guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
Synonym:	oligosaccharide-lipid mannosyltransferase activity
GO id:	GO:0004377
Definition:	Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Number of paths to term:	2

denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship

Gene_Ontology

molecular_function

catalytic activity

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring hexosyl groups

mannosyltransferase activity

alpha-1,2-mannosyltransferase activity

dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0004377] (1 genes, 1 annotations)