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Gene Ontology Browser
Term Detail
GO term:ubiquitin thiolesterase activity
Synonym: ubiquitin carboxy-terminal esterase activity
Synonym: ubiquitin carboxy-terminal hydrolase activity
Synonym: ubiquitin C-terminal hydrolase activity
Synonym: ubiquitin-C-terminal-thioester hydrolase activity
Synonym: ubiquitin thioesterase activity
Synonym: ubiquitinyl hydrolase 1 activity
GO id:GO:0004221
Definition:Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
CommentsNote that this term is distinguished from 'ubiquitin-specific protease activity ; GO:0004843' in that it specifically refers to hydrolysis of thiolester bonds, but encompasses the removal of any substrate attached to ubiquitin via a thiolester bond.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-athiolester hydrolase activity
                                                is-a2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
                                                is-a2-oxoglutaryl-CoA thioesterase activity
                                                is-a3-isopropylbut-3-enoyl-CoA thioesterase activity
                                                is-a[citrate-(pro-3S)-lyase] thiolesterase activity
                                                is-aacyl-[acyl-carrier-protein] hydrolase activity +
                                                is-aCoA hydrolase activity +
                                                is-aglutathione thiolesterase activity
                                                is-ahydroxyacylglutathione hydrolase activity
                                                is-apalmitoyl-(protein) hydrolase activity
                                                is-aS-formylglutathione hydrolase activity
                                                is-aS-succinylglutathione hydrolase activity
                                                is-aubiquitin thiolesterase activity [GO:0004221] (62 genes, 65 annotations)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory