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Gene Ontology Browser
Term Detail
GO term:ubiquitin thiolesterase activity
Synonym: ubiquitin carboxy-terminal esterase activity
Synonym: ubiquitin carboxy-terminal hydrolase activity
Synonym: ubiquitin C-terminal hydrolase activity
Synonym: ubiquitin-C-terminal-thioester hydrolase activity
Synonym: ubiquitin thioesterase activity
Synonym: ubiquitinyl hydrolase 1 activity
GO id:GO:0004221
Definition:Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
CommentsUse GO:0004221 with caution because it is unclear if this activity exists. Consider instead annotating to 'ubiquitinyl hydrolase activity ; GO:0036459'. Note that this term is distinguished from 'ubiquitin-specific protease activity ; GO:0004843' in that it specifically refers to the removal of any substrate attached to ubiquitin via a thiolester bond.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-athiolester hydrolase activity
                                                is-a2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
                                                is-a2-oxoglutaryl-CoA thioesterase activity
                                                is-a3-isopropylbut-3-enoyl-CoA thioesterase activity
                                                is-a[citrate-(pro-3S)-lyase] thiolesterase activity
                                                is-aacyl-[acyl-carrier-protein] hydrolase activity +
                                                is-aCoA hydrolase activity +
                                                is-aglutathione thiolesterase activity
                                                is-ahydroxyacylglutathione hydrolase activity
                                                is-apalmitoyl-(protein) hydrolase activity
                                                is-aS-formylglutathione hydrolase activity
                                                is-aS-succinylglutathione hydrolase activity
                                                is-aubiquitin thiolesterase activity [GO:0004221] (30 genes, 35 annotations)


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-aubiquitinyl hydrolase activity
                                        is-aubiquitin thiolesterase activity [GO:0004221] (30 genes, 35 annotations)
                                        is-aubiquitin-specific protease activity +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory