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Gene Ontology Browser
Term Detail
GO term:Factor XII activation
Synonym: Hageman factor activation
GO id:GO:0002542
Definition:Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Number of paths to term: 70

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-apositive regulation of biological process
                                        is-apositive regulation of metabolic process
                                                is-apositive regulation of macromolecule metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-apositive regulation of metabolic process
                                                is-apositive regulation of macromolecule metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-apositive regulation of macromolecule metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-aregulation of gene expression
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-aregulation of protein metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-aregulation of protein metabolic process
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of primary metabolic process
                                                is-aregulation of protein metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of primary metabolic process
                                                is-aregulation of protein metabolic process
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of response to external stimulus
                                                is-aregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of response to stimulus
                                        is-aregulation of response to stress
                                                is-aregulation of defense response
                                                        is-aregulation of inflammatory response
                                                                is-aregulation of acute inflammatory response
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-anegative regulation of acute inflammatory response +
                                                                        is-anegative regulation of B cell deletion +
                                                                        is-anegative regulation of natural killer cell tolerance induction
                                                                        is-apositive regulation of acute inflammatory response +
                                                                        is-apositive regulation of B cell deletion +
                                                                        is-apositive regulation of natural killer cell tolerance induction
                                                                        is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                        is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                        is-aregulation of complement activation +
                                                                        is-aregulation of fever generation +
                                                                        is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                part-ofprotein maturation
                                                        is-aprotein processing
                                                                is-aactivation of plasma proteins involved in acute inflammatory response
                                                                        positively-regulatesFactor XII activation [GO:0002542] (1 genes, 1 annotations)


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                part-ofprotein maturation
                                                        is-aprotein processing
                                                                positively-regulatespositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                part-ofprotein maturation
                                                        is-aprotein processing
                                                                regulatesregulation of protein processing
                                                                        is-apositive regulation of protein processing
                                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                                is-apositive regulation of complement activation +
                                                                                is-apositive regulation of peptide hormone processing
                                                                                is-apositive regulation of plasminogen activation
                                                                                is-apositive regulation of proteolysis +
                                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                regulatesregulation of gene expression
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        positively-regulatespositive regulation of macromolecule metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                positively-regulatespositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein activation cascade
                                                        is-akinin cascade
                                                                is-aplasma kallikrein-kinin cascade
                                                                        part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                                        positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                                        regulatesregulation of plasma kallikrein-kinin cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein maturation
                                                        is-aprotein processing
                                                                is-aactivation of plasma proteins involved in acute inflammatory response
                                                                        positively-regulatesFactor XII activation [GO:0002542] (1 genes, 1 annotations)


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein maturation
                                                        is-aprotein processing
                                                                positively-regulatespositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein maturation
                                                        is-aprotein processing
                                                                regulatesregulation of protein processing
                                                                        is-apositive regulation of protein processing
                                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                                is-apositive regulation of complement activation +
                                                                                is-apositive regulation of peptide hormone processing
                                                                                is-apositive regulation of plasminogen activation
                                                                                is-apositive regulation of proteolysis +
                                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                regulatesregulation of protein metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                regulatesregulation of protein metabolic process
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-apositive regulation of macromolecule metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-aregulation of gene expression
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-aregulation of protein metabolic process
                                                        is-apositive regulation of protein metabolic process
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-aregulation of protein metabolic process
                                                        is-aregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        positively-regulatespositive regulation of metabolic process
                                is-apositive regulation of macromolecule metabolic process
                                        is-apositive regulation of protein metabolic process
                                                is-apositive regulation of protein processing
                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        is-apositive regulation of complement activation +
                                                        is-apositive regulation of peptide hormone processing
                                                        is-apositive regulation of plasminogen activation
                                                        is-apositive regulation of proteolysis +
                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        positively-regulatespositive regulation of protein metabolic process
                                                is-apositive regulation of protein processing
                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        is-apositive regulation of complement activation +
                                                        is-apositive regulation of peptide hormone processing
                                                        is-apositive regulation of plasminogen activation
                                                        is-apositive regulation of proteolysis +
                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein activation cascade
                                                is-akinin cascade
                                                        is-aplasma kallikrein-kinin cascade
                                                                part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                                positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                                regulatesregulation of plasma kallikrein-kinin cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein maturation
                                                is-aprotein processing
                                                        is-aactivation of plasma proteins involved in acute inflammatory response
                                                                positively-regulatesFactor XII activation [GO:0002542] (1 genes, 1 annotations)


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein maturation
                                                is-aprotein processing
                                                        positively-regulatespositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein maturation
                                                is-aprotein processing
                                                        regulatesregulation of protein processing
                                                                is-apositive regulation of protein processing
                                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        is-apositive regulation of complement activation +
                                                                        is-apositive regulation of peptide hormone processing
                                                                        is-apositive regulation of plasminogen activation
                                                                        is-apositive regulation of proteolysis +
                                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        regulatesregulation of protein metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        regulatesregulation of protein metabolic process
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                regulatesregulation of primary metabolic process
                                        is-aregulation of protein metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                regulatesregulation of primary metabolic process
                                        is-aregulation of protein metabolic process
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-apositive regulation of metabolic process
                                        is-apositive regulation of macromolecule metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-apositive regulation of macromolecule metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of gene expression
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of protein metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of protein metabolic process
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of primary metabolic process
                                        is-aregulation of protein metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of primary metabolic process
                                        is-aregulation of protein metabolic process
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-aprotein activation cascade
                                        is-akinin cascade
                                                is-aplasma kallikrein-kinin cascade
                                                        part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                        positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                        regulatesregulation of plasma kallikrein-kinin cascade +


Gene_Ontology
        is-abiological_process
                positively-regulatespositive regulation of biological process
                        is-apositive regulation of metabolic process
                                is-apositive regulation of macromolecule metabolic process
                                        is-apositive regulation of protein metabolic process
                                                is-apositive regulation of protein processing
                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        is-apositive regulation of complement activation +
                                                        is-apositive regulation of peptide hormone processing
                                                        is-apositive regulation of plasminogen activation
                                                        is-apositive regulation of proteolysis +
                                                        is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-apositive regulation of biological process
                                is-apositive regulation of metabolic process
                                        is-apositive regulation of macromolecule metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-apositive regulation of metabolic process
                                        is-apositive regulation of macromolecule metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-apositive regulation of macromolecule metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of gene expression
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of protein metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-aregulation of protein metabolic process
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of primary metabolic process
                                        is-aregulation of protein metabolic process
                                                is-apositive regulation of protein metabolic process
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of primary metabolic process
                                        is-aregulation of protein metabolic process
                                                is-aregulation of protein processing
                                                        is-apositive regulation of protein processing
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-apositive regulation of complement activation +
                                                                is-apositive regulation of peptide hormone processing
                                                                is-apositive regulation of plasminogen activation
                                                                is-apositive regulation of proteolysis +
                                                                is-apositive regulation of sterol regulatory element binding protein cleavage


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of response to stimulus
                                is-aregulation of response to external stimulus
                                        is-aregulation of inflammatory response
                                                is-aregulation of acute inflammatory response
                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        is-anegative regulation of acute inflammatory response +
                                                        is-anegative regulation of B cell deletion +
                                                        is-anegative regulation of natural killer cell tolerance induction
                                                        is-apositive regulation of acute inflammatory response +
                                                        is-apositive regulation of B cell deletion +
                                                        is-apositive regulation of natural killer cell tolerance induction
                                                        is-aregulation of acute inflammatory response to antigenic stimulus +
                                                        is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                        is-aregulation of complement activation +
                                                        is-aregulation of fever generation +
                                                        is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of response to stimulus
                                is-aregulation of response to stress
                                        is-aregulation of defense response
                                                is-aregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aprotein activation cascade
                                is-akinin cascade
                                        is-aplasma kallikrein-kinin cascade
                                                part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                regulatesregulation of plasma kallikrein-kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        regulatesregulation of response to stimulus
                                is-aregulation of response to external stimulus
                                        is-aregulation of inflammatory response
                                                is-aregulation of acute inflammatory response
                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        is-anegative regulation of acute inflammatory response +
                                                        is-anegative regulation of B cell deletion +
                                                        is-anegative regulation of natural killer cell tolerance induction
                                                        is-apositive regulation of acute inflammatory response +
                                                        is-apositive regulation of B cell deletion +
                                                        is-apositive regulation of natural killer cell tolerance induction
                                                        is-aregulation of acute inflammatory response to antigenic stimulus +
                                                        is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                        is-aregulation of complement activation +
                                                        is-aregulation of fever generation +
                                                        is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        regulatesregulation of response to stimulus
                                is-aregulation of response to stress
                                        is-aregulation of defense response
                                                is-aregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to external stimulus
                                regulatesregulation of response to external stimulus
                                        is-aregulation of inflammatory response
                                                is-aregulation of acute inflammatory response
                                                        is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        is-anegative regulation of acute inflammatory response +
                                                        is-anegative regulation of B cell deletion +
                                                        is-anegative regulation of natural killer cell tolerance induction
                                                        is-apositive regulation of acute inflammatory response +
                                                        is-apositive regulation of B cell deletion +
                                                        is-apositive regulation of natural killer cell tolerance induction
                                                        is-aregulation of acute inflammatory response to antigenic stimulus +
                                                        is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                        is-aregulation of complement activation +
                                                        is-aregulation of fever generation +
                                                        is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-adefense response
                                        is-ainflammatory response
                                                is-aacute inflammatory response
                                                        part-ofactivation of plasma proteins involved in acute inflammatory response
                                                                positively-regulatesFactor XII activation [GO:0002542] (1 genes, 1 annotations)


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-adefense response
                                        is-ainflammatory response
                                                is-aacute inflammatory response
                                                        is-akinin cascade
                                                                is-aplasma kallikrein-kinin cascade
                                                                        part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                                        positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                                        regulatesregulation of plasma kallikrein-kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-adefense response
                                        is-ainflammatory response
                                                is-aacute inflammatory response
                                                        regulatesregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-adefense response
                                        is-ainflammatory response
                                                regulatesregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-adefense response
                                        regulatesregulation of defense response
                                                is-aregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                regulatesregulation of response to stress
                                        is-aregulation of defense response
                                                is-aregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to wounding
                                        is-ainflammatory response
                                                is-aacute inflammatory response
                                                        part-ofactivation of plasma proteins involved in acute inflammatory response
                                                                positively-regulatesFactor XII activation [GO:0002542] (1 genes, 1 annotations)


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to wounding
                                        is-ainflammatory response
                                                is-aacute inflammatory response
                                                        is-akinin cascade
                                                                is-aplasma kallikrein-kinin cascade
                                                                        part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                        negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                                        positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                                        regulatesregulation of plasma kallikrein-kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to wounding
                                        is-ainflammatory response
                                                is-aacute inflammatory response
                                                        regulatesregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to wounding
                                        is-ainflammatory response
                                                regulatesregulation of inflammatory response
                                                        is-aregulation of acute inflammatory response
                                                                is-aFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                                is-anegative regulation of acute inflammatory response +
                                                                is-anegative regulation of B cell deletion +
                                                                is-anegative regulation of natural killer cell tolerance induction
                                                                is-apositive regulation of acute inflammatory response +
                                                                is-apositive regulation of B cell deletion +
                                                                is-apositive regulation of natural killer cell tolerance induction
                                                                is-aregulation of acute inflammatory response to antigenic stimulus +
                                                                is-aregulation of acute inflammatory response to non-antigenic stimulus +
                                                                is-aregulation of complement activation +
                                                                is-aregulation of fever generation +
                                                                is-aregulation of kinin cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-aprotein activation cascade
                                        is-akinin cascade
                                                is-aplasma kallikrein-kinin cascade
                                                        part-ofFactor XII activation [GO:0002542] (1 genes, 1 annotations)
                                                        negatively-regulatesnegative regulation of plasma kallikrein-kinin cascade
                                                        positively-regulatespositive regulation of plasma kallikrein-kinin cascade
                                                        regulatesregulation of plasma kallikrein-kinin cascade +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory