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Term Detail
GO term:adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO id:GO:0002460
Definition:An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                is-aadaptive immune response
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [GO:0002460] (214 genes, 330 annotations)
                                                is-aB cell mediated immunity +
                                                is-agerminal center formation +
                                                negatively-regulatesnegative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +
                                                positively-regulatespositive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +
                                                regulatesregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +
                                                is-aT cell mediated immunity +
                                                is-aT-helper 1 type immune response +
                                                is-aT-helper 17 type immune response +
                                                is-atolerance induction dependent upon immune response +
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
                                        negatively-regulatesnegative regulation of adaptive immune response +
                                        positively-regulatespositive regulation of adaptive immune response +
                                        regulatesregulation of adaptive immune response +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                is-aadaptive immune response
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [GO:0002460] (214 genes, 330 annotations)
                                                is-aB cell mediated immunity +
                                                is-agerminal center formation +
                                                negatively-regulatesnegative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +
                                                positively-regulatespositive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +
                                                regulatesregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +
                                                is-aT cell mediated immunity +
                                                is-aT-helper 1 type immune response +
                                                is-aT-helper 17 type immune response +
                                                is-atolerance induction dependent upon immune response +
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
                                        negatively-regulatesnegative regulation of adaptive immune response +
                                        positively-regulatespositive regulation of adaptive immune response +
                                        regulatesregulation of adaptive immune response +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory