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Gene Ontology Browser
Term Detail
GO term:pre-B cell differentiation
Synonym: pre-B cell development
Synonym: pre-B lymphocyte differentiation
GO id:GO:0002329
Definition:The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
CommentsNote that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Number of paths to term: 24

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-aB cell activation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aorgan development
                                        is-ahematopoietic or lymphoid organ development
                                                is-ahemopoiesis
                                                        part-ofleukocyte differentiation
                                                                is-alymphocyte differentiation
                                                                        is-aB cell differentiation
                                                                                is-aimmature B cell differentiation
                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                part-ofpre-B cell receptor expression
                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        is-aimmune system development
                                                part-ofhematopoietic or lymphoid organ development
                                                        is-ahemopoiesis
                                                                part-ofleukocyte differentiation
                                                                        is-alymphocyte differentiation
                                                                                is-aB cell differentiation
                                                                                        is-aimmature B cell differentiation
                                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                        part-ofpre-B cell allelic exclusion
                                                                                                        part-ofpre-B cell receptor expression
                                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-oforgan development
                                                is-ahematopoietic or lymphoid organ development
                                                        is-ahemopoiesis
                                                                part-ofleukocyte differentiation
                                                                        is-alymphocyte differentiation
                                                                                is-aB cell differentiation
                                                                                        is-aimmature B cell differentiation
                                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                        part-ofpre-B cell allelic exclusion
                                                                                                        part-ofpre-B cell receptor expression
                                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-ahematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune system development
                                part-ofhematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aleukocyte activation
                                is-alymphocyte activation
                                        is-aB cell activation
                                                is-aB cell differentiation
                                                        is-aimmature B cell differentiation
                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                        part-ofpre-B cell allelic exclusion
                                                                        part-ofpre-B cell receptor expression
                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aleukocyte activation
                                is-alymphocyte activation
                                        is-alymphocyte differentiation
                                                is-aB cell differentiation
                                                        is-aimmature B cell differentiation
                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                        part-ofpre-B cell allelic exclusion
                                                                        part-ofpre-B cell receptor expression
                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-aB cell activation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aleukocyte activation
                                                is-alymphocyte activation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-ahematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-alymphocyte differentiation
                                                                is-aB cell differentiation
                                                                        is-aimmature B cell differentiation
                                                                                is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                        part-ofpre-B cell allelic exclusion
                                                                                        part-ofpre-B cell receptor expression
                                                                                is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-alymphocyte differentiation
                                                                                        is-aB cell differentiation
                                                                                                is-aimmature B cell differentiation
                                                                                                        is-apre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)
                                                                                                                part-ofpre-B cell allelic exclusion
                                                                                                                part-ofpre-B cell receptor expression
                                                                                                        is-atransitional stage B cell differentiation +


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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory