| GO term: | pre-B cell differentiation |
| Synonym: | pre-B cell development |
| Synonym: | pre-B lymphocyte differentiation |
| GO id: | GO:0002329 |
| Definition: | The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments. |
| Comments | Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. |
| Number of paths to term: | 21 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationB cell activationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationB cell activationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationB cell activationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationimmature B cell differentiationpre-B cell differentiation [GO:0002329] (12 genes, 13 annotations)pre-B cell allelic exclusionpre-B cell receptor expressiontransitional stage B cell differentiation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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