| GO term: | RNA polymerase II transcription coactivator activity |
| Synonym: | RNA polymerase II transcription co-activator activity |
| GO id: | GO:0001105 |
| Definition: | Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. |
| Comments | Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor. |
| Number of paths to term: | 4 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functionprotein binding transcription factor activitytranscription factor binding transcription factor activityRNA polymerase II transcription factor binding transcription factor activityRNA polymerase II transcription cofactor activityRNA polymerase II transcription coactivator activity [GO:0001105] (24 genes, 28 annotations)RNA polymerase II transcription coactivator activity involved in preinitiation complex assemblyRNA polymerase II transcription corepressor activitymolecular_functionprotein binding transcription factor activitytranscription factor binding transcription factor activityRNA polymerase II transcription factor binding transcription factor activityRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionRNA polymerase II transcription coactivator activity [GO:0001105] (24 genes, 28 annotations)RNA polymerase II transcription coactivator activity involved in preinitiation complex assemblymolecular_functionprotein binding transcription factor activitytranscription factor binding transcription factor activitytranscription cofactor activityRNA polymerase II transcription cofactor activityRNA polymerase II transcription coactivator activity [GO:0001105] (24 genes, 28 annotations)RNA polymerase II transcription coactivator activity involved in preinitiation complex assemblyRNA polymerase II transcription corepressor activitymolecular_functionprotein binding transcription factor activitytranscription factor binding transcription factor activitytranscription cofactor activitytranscription coactivator activitycAMP response element binding protein bindingligand-dependent nuclear receptor transcription coactivator activity +RNA polymerase II transcription coactivator activity [GO:0001105] (24 genes, 28 annotations)RNA polymerase II transcription coactivator activity involved in preinitiation complex assemblyMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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