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Term Detail
GO term:RNA polymerase II transcription coactivator activity
Synonym: RNA polymerase II transcription co-activator activity
GO id:GO:0001105
Definition:Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
CommentsNote that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-aprotein binding transcription factor activity
                        is-atranscription factor binding transcription factor activity
                                is-aRNA polymerase II transcription factor binding transcription factor activity
                                        is-aRNA polymerase II transcription cofactor activity
                                                is-aRNA polymerase II transcription coactivator activity [GO:0001105] (26 genes, 30 annotations)
                                                        is-aRNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
                                                is-aRNA polymerase II transcription corepressor activity


Gene_Ontology
        is-amolecular_function
                is-aprotein binding transcription factor activity
                        is-atranscription factor binding transcription factor activity
                                is-aRNA polymerase II transcription factor binding transcription factor activity
                                        is-aRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
                                                is-aRNA polymerase II transcription coactivator activity [GO:0001105] (26 genes, 30 annotations)
                                                        is-aRNA polymerase II transcription coactivator activity involved in preinitiation complex assembly


Gene_Ontology
        is-amolecular_function
                is-aprotein binding transcription factor activity
                        is-atranscription factor binding transcription factor activity
                                is-atranscription cofactor activity
                                        is-aRNA polymerase II transcription cofactor activity
                                                is-aRNA polymerase II transcription coactivator activity [GO:0001105] (26 genes, 30 annotations)
                                                        is-aRNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
                                                is-aRNA polymerase II transcription corepressor activity


Gene_Ontology
        is-amolecular_function
                is-aprotein binding transcription factor activity
                        is-atranscription factor binding transcription factor activity
                                is-atranscription cofactor activity
                                        is-atranscription coactivator activity
                                                is-acAMP response element binding protein binding
                                                is-aligand-dependent nuclear receptor transcription coactivator activity +
                                                is-aRNA polymerase II transcription coactivator activity [GO:0001105] (26 genes, 30 annotations)
                                                        is-aRNA polymerase II transcription coactivator activity involved in preinitiation complex assembly


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory