About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:phosphorelay signal transduction system
Synonym: histidyl-aspartyl phosphorelay
Synonym: phosphorelay signal transduction system
GO id:GO:0000160
Definition:A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                                is-aethylene-activated signaling pathway +
                                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                                is-aosmosensory signaling via phosphorelay pathway
                                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                                regulatesregulation of phosphorelay signal transduction system +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        is-aprotein kinase D signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                                is-aethylene-activated signaling pathway +
                                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                                is-aosmosensory signaling via phosphorelay pathway
                                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                                regulatesregulation of phosphorelay signal transduction system +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        is-aprotein kinase D signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                                is-aethylene-activated signaling pathway +
                                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                                is-aosmosensory signaling via phosphorelay pathway
                                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                                regulatesregulation of phosphorelay signal transduction system +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        is-aprotein kinase D signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory