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Gene Ontology Browser
Term Detail
GO term:phosphorelay signal transduction system
Synonym: histidyl-aspartyl phosphorelay
Synonym: phosphorelay signal transduction system
GO id:GO:0000160
Definition:A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                is-aethylene-activated signaling pathway +
                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                is-aosmosensory signaling via phosphorelay pathway
                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                regulatesregulation of phosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                is-aethylene-activated signaling pathway +
                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                is-aosmosensory signaling via phosphorelay pathway
                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                regulatesregulation of phosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                is-aethylene-activated signaling pathway +
                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                is-aosmosensory signaling via phosphorelay pathway
                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                regulatesregulation of phosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                is-aethylene-activated signaling pathway +
                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                is-aosmosensory signaling via phosphorelay pathway
                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                regulatesregulation of phosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                is-aethylene-activated signaling pathway +
                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                is-aosmosensory signaling via phosphorelay pathway
                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                regulatesregulation of phosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                is-aethylene-activated signaling pathway +
                                                negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                is-aosmosensory signaling via phosphorelay pathway
                                                positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                regulatesregulation of phosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphosphorelay signal transduction system [GO:0000160] (7 genes, 7 annotations)
                                                        is-aethylene-activated signaling pathway +
                                                        negatively-regulatesnegative regulation of phosphorelay signal transduction system +
                                                        is-aosmosensory signaling via phosphorelay pathway
                                                        positively-regulatespositive regulation of phosphorelay signal transduction system +
                                                        regulatesregulation of phosphorelay signal transduction system +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory