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Gene Ontology Browser
Term Detail
GO term:phosphorelay sensor kinase activity
Synonym: two-component sensor activity
Synonym: two-component sensor molecule
Synonym: two-component system sensor activity
GO id:GO:0000155
Definition:Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-aprotein histidine kinase activity
                                                                is-aphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)
                                                                is-aprotein histidine pros-kinase activity
                                                                is-aprotein histidine tele-kinase activity
                                                                is-atransmembrane receptor histidine kinase activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-aprotein histidine kinase activity
                                                                is-aphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)
                                                                is-aprotein histidine pros-kinase activity
                                                                is-aprotein histidine tele-kinase activity
                                                                is-atransmembrane receptor histidine kinase activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, nitrogenous group as acceptor
                                                is-aprotein histidine kinase activity
                                                        is-aphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)
                                                        is-aprotein histidine pros-kinase activity
                                                        is-aprotein histidine tele-kinase activity
                                                        is-atransmembrane receptor histidine kinase activity +


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-asignaling receptor activity
                                        is-aadvanced glycation end-product receptor activity
                                        is-aaryl hydrocarbon receptor activity
                                        is-aauxin receptor activity
                                        is-abile acid receptor activity +
                                        is-acalcitriol receptor activity
                                        is-acoreceptor activity +
                                        is-adiuretic hormone receptor activity
                                        is-aethylene receptor activity +
                                        is-ahigh molecular weight B cell growth factor receptor activity
                                        is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                        is-ajuvenile hormone receptor activity
                                        is-aleucokinin receptor activity
                                        is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                        is-aneurotransmitter receptor activity +
                                        is-aneurotrophin receptor activity +
                                        is-apeptide receptor activity +
                                        is-aphorbol ester receptor activity +
                                        is-aphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)
                                        is-aphotoreceptor activity +
                                        is-aretinoic acid receptor activity +
                                        is-asignaling pattern recognition receptor activity +
                                        is-asteroid hormone receptor activity +
                                        is-athrombospondin receptor activity
                                        is-athyroid hormone receptor activity
                                        is-atransmembrane signaling receptor activity +
                                        is-aurokinase plasminogen activator receptor activity


Gene_Ontology
        is-amolecular_function
                is-areceptor activity
                        is-asignaling receptor activity
                                is-aadvanced glycation end-product receptor activity
                                is-aaryl hydrocarbon receptor activity
                                is-aauxin receptor activity
                                is-abile acid receptor activity +
                                is-acalcitriol receptor activity
                                is-acoreceptor activity +
                                is-adiuretic hormone receptor activity
                                is-aethylene receptor activity +
                                is-ahigh molecular weight B cell growth factor receptor activity
                                is-ainositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
                                is-ajuvenile hormone receptor activity
                                is-aleucokinin receptor activity
                                is-aligand-activated RNA polymerase II transcription factor binding transcription factor activity +
                                is-aneurotransmitter receptor activity +
                                is-aneurotrophin receptor activity +
                                is-apeptide receptor activity +
                                is-aphorbol ester receptor activity +
                                is-aphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)
                                is-aphotoreceptor activity +
                                is-aretinoic acid receptor activity +
                                is-asignaling pattern recognition receptor activity +
                                is-asteroid hormone receptor activity +
                                is-athrombospondin receptor activity
                                is-athyroid hormone receptor activity
                                is-atransmembrane signaling receptor activity +
                                is-aurokinase plasminogen activator receptor activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory