| GO term: | phosphorelay sensor kinase activity |
| Synonym: | two-component sensor activity |
| Synonym: | two-component sensor molecule |
| Synonym: | two-component system sensor activity |
| GO id: | GO:0000155 |
| Definition: | Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. |
| Number of paths to term: | 5 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupskinase activityprotein kinase activityprotein histidine kinase activityphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)protein histidine pros-kinase activityprotein histidine tele-kinase activitytransmembrane receptor histidine kinase activity +molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupsphosphotransferase activity, alcohol group as acceptorprotein kinase activityprotein histidine kinase activityphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)protein histidine pros-kinase activityprotein histidine tele-kinase activitytransmembrane receptor histidine kinase activity +molecular_functioncatalytic activitytransferase activitytransferase activity, transferring phosphorus-containing groupsphosphotransferase activity, nitrogenous group as acceptorprotein histidine kinase activityphosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)protein histidine pros-kinase activityprotein histidine tele-kinase activitytransmembrane receptor histidine kinase activity +molecular_functionmolecular transducer activitysignal transducer activitysignaling receptor activityadvanced glycation end-product receptor activityaryl hydrocarbon receptor activitycoreceptor activity +corticotropin-releasing hormone receptor activitydiuretic hormone receptor activityhigh molecular weight B cell growth factor receptor activityinositol 1,4,5-trisphosphate-sensitive calcium-release channel activityleucokinin receptor activityligand-activated RNA polymerase II transcription factor binding transcription factor activity +ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity +neurotransmitter receptor activity +neurotrophin receptor activity +pattern recognition receptor activity +peptide receptor activity +phorbol ester receptor activity +phosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)photoreceptor activity +steroid hormone receptor activity +thrombospondin receptor activitytransmembrane signaling receptor activity +U-plasminogen activator receptor activitymolecular_functionreceptor activitysignaling receptor activityadvanced glycation end-product receptor activityaryl hydrocarbon receptor activitycoreceptor activity +corticotropin-releasing hormone receptor activitydiuretic hormone receptor activityhigh molecular weight B cell growth factor receptor activityinositol 1,4,5-trisphosphate-sensitive calcium-release channel activityleucokinin receptor activityligand-activated RNA polymerase II transcription factor binding transcription factor activity +ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity +neurotransmitter receptor activity +neurotrophin receptor activity +pattern recognition receptor activity +peptide receptor activity +phorbol ester receptor activity +phosphorelay sensor kinase activity [GO:0000155] (5 genes, 5 annotations)photoreceptor activity +steroid hormone receptor activity +thrombospondin receptor activitytransmembrane signaling receptor activity +U-plasminogen activator receptor activityMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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