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Gene Ontology Browser
Term Detail
GO term:cell cycle checkpoint
Synonym: G1/S checkpoint
Synonym: G1/S transition checkpoint
Synonym: G2/M checkpoint
Synonym: G2/M transition checkpoint
GO id:GO:0000075
Alternate id: GO:0031576, GO:0071779
Definition:A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
CommentsThis term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-aactin filament reorganization involved in cell cycle
                                                is-aactomyosin contractile ring assembly actin filament organization +
                                                is-aattachment of spindle microtubules to kinetochore +
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (162 genes, 222 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-acell cycle DNA replication +
                                                is-acell cycle DNA replication DNA ligation +
                                                is-acell cycle DNA replication DNA unwinding +
                                                is-acell cycle DNA replication initiation +
                                                is-acell cycle DNA replication maintenance of fidelity +
                                                is-acell cycle DNA replication termination +
                                                is-acell cycle phase transition +
                                                is-acell cycle switching +
                                                is-acentriole elongation +
                                                is-acentriole replication +
                                                is-acentromere separation +
                                                is-acentrosome cycle +
                                                is-acentrosome duplication +
                                                is-acentrosome separation +
                                                is-achromosome attachment to the nuclear envelope +
                                                is-achromosome movement towards spindle pole +
                                                is-achromosome separation +
                                                is-acohesin localization to chromatin +
                                                is-acytokinesis +
                                                is-acytokinetic process +
                                                is-aDNA replication preinitiation complex assembly +
                                                is-aDNA strand elongation involved in cell cycle DNA replication +
                                                is-aestablishment of sister chromatid cohesion +
                                                is-aG0 to G1 transition +
                                                is-aG1 to G0 transition +
                                                is-ainterphase microtubule nucleation by interphase microtubule organizing center
                                                is-amaintenance of protein location in spindle pole body
                                                is-amaintenance of sister chromatid cohesion +
                                                is-ameiotic cell cycle process +
                                                is-amicrotubule anchoring at spindle pole body +
                                                is-amitotic cell cycle process +
                                                is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                                negatively-regulatesnegative regulation of cell cycle process +
                                                is-anuclear chromosome segregation +
                                                positively-regulatespositive regulation of cell cycle process +
                                                is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                                is-aprotein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly +
                                                is-are-entry into mitotic cell cycle +
                                                regulatesregulation of cell cycle process +
                                                is-aregulation of syncytial blastoderm mitotic cell cycle +
                                                is-asecondary cell wall biogenesis involved in seed trichome differentiation
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asister chromatid cohesion +
                                                is-aspindle elongation +
                                                is-aspindle localization +
                                                is-aspindle midzone assembly +
                                                is-aspindle organization +
                                                is-aspindle pole body organization +
                                                is-aspindle pole body separation +
                                                is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                                is-atelomere maintenance via semi-conservative replication +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-aactin filament reorganization involved in cell cycle
                                        is-aactomyosin contractile ring assembly actin filament organization +
                                        is-aattachment of spindle microtubules to kinetochore +
                                        is-acell cycle arrest +
                                        is-acell cycle checkpoint [GO:0000075] (162 genes, 222 annotations)
                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                is-aDNA integrity checkpoint +
                                                is-ameiotic cell cycle checkpoint +
                                                is-amitotic cell cycle checkpoint +
                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                regulatesregulation of cell cycle checkpoint +
                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                is-aspindle checkpoint +
                                        is-acell cycle DNA replication +
                                        is-acell cycle DNA replication DNA ligation +
                                        is-acell cycle DNA replication DNA unwinding +
                                        is-acell cycle DNA replication initiation +
                                        is-acell cycle DNA replication maintenance of fidelity +
                                        is-acell cycle DNA replication termination +
                                        is-acell cycle phase transition +
                                        is-acell cycle switching +
                                        is-acentriole elongation +
                                        is-acentriole replication +
                                        is-acentromere separation +
                                        is-acentrosome cycle +
                                        is-acentrosome duplication +
                                        is-acentrosome separation +
                                        is-achromosome attachment to the nuclear envelope +
                                        is-achromosome movement towards spindle pole +
                                        is-achromosome separation +
                                        is-acohesin localization to chromatin +
                                        is-acytokinesis +
                                        is-acytokinetic process +
                                        is-aDNA replication preinitiation complex assembly +
                                        is-aDNA strand elongation involved in cell cycle DNA replication +
                                        is-aestablishment of sister chromatid cohesion +
                                        is-aG0 to G1 transition +
                                        is-aG1 to G0 transition +
                                        is-ainterphase microtubule nucleation by interphase microtubule organizing center
                                        is-amaintenance of protein location in spindle pole body
                                        is-amaintenance of sister chromatid cohesion +
                                        is-ameiotic cell cycle process +
                                        is-amicrotubule anchoring at spindle pole body +
                                        is-amitotic cell cycle process +
                                        is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                        negatively-regulatesnegative regulation of cell cycle process +
                                        is-anuclear chromosome segregation +
                                        positively-regulatespositive regulation of cell cycle process +
                                        is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                        is-aprotein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly +
                                        is-are-entry into mitotic cell cycle +
                                        regulatesregulation of cell cycle process +
                                        is-aregulation of syncytial blastoderm mitotic cell cycle +
                                        is-asecondary cell wall biogenesis involved in seed trichome differentiation
                                        is-asignal transduction involved in cell cycle checkpoint +
                                        is-asister chromatid cohesion +
                                        is-aspindle elongation +
                                        is-aspindle localization +
                                        is-aspindle midzone assembly +
                                        is-aspindle organization +
                                        is-aspindle pole body organization +
                                        is-aspindle pole body separation +
                                        is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                        is-atelomere maintenance via semi-conservative replication +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-aactin filament reorganization involved in cell cycle
                                                is-aactomyosin contractile ring assembly actin filament organization +
                                                is-aattachment of spindle microtubules to kinetochore +
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (162 genes, 222 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-acell cycle DNA replication +
                                                is-acell cycle DNA replication DNA ligation +
                                                is-acell cycle DNA replication DNA unwinding +
                                                is-acell cycle DNA replication initiation +
                                                is-acell cycle DNA replication maintenance of fidelity +
                                                is-acell cycle DNA replication termination +
                                                is-acell cycle phase transition +
                                                is-acell cycle switching +
                                                is-acentriole elongation +
                                                is-acentriole replication +
                                                is-acentromere separation +
                                                is-acentrosome cycle +
                                                is-acentrosome duplication +
                                                is-acentrosome separation +
                                                is-achromosome attachment to the nuclear envelope +
                                                is-achromosome movement towards spindle pole +
                                                is-achromosome separation +
                                                is-acohesin localization to chromatin +
                                                is-acytokinesis +
                                                is-acytokinetic process +
                                                is-aDNA replication preinitiation complex assembly +
                                                is-aDNA strand elongation involved in cell cycle DNA replication +
                                                is-aestablishment of sister chromatid cohesion +
                                                is-aG0 to G1 transition +
                                                is-aG1 to G0 transition +
                                                is-ainterphase microtubule nucleation by interphase microtubule organizing center
                                                is-amaintenance of protein location in spindle pole body
                                                is-amaintenance of sister chromatid cohesion +
                                                is-ameiotic cell cycle process +
                                                is-amicrotubule anchoring at spindle pole body +
                                                is-amitotic cell cycle process +
                                                is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                                negatively-regulatesnegative regulation of cell cycle process +
                                                is-anuclear chromosome segregation +
                                                positively-regulatespositive regulation of cell cycle process +
                                                is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                                is-aprotein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly +
                                                is-are-entry into mitotic cell cycle +
                                                regulatesregulation of cell cycle process +
                                                is-aregulation of syncytial blastoderm mitotic cell cycle +
                                                is-asecondary cell wall biogenesis involved in seed trichome differentiation
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asister chromatid cohesion +
                                                is-aspindle elongation +
                                                is-aspindle localization +
                                                is-aspindle midzone assembly +
                                                is-aspindle organization +
                                                is-aspindle pole body organization +
                                                is-aspindle pole body separation +
                                                is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                                is-atelomere maintenance via semi-conservative replication +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-aactin filament reorganization involved in cell cycle
                                        is-aactomyosin contractile ring assembly actin filament organization +
                                        is-aattachment of spindle microtubules to kinetochore +
                                        is-acell cycle arrest +
                                        is-acell cycle checkpoint [GO:0000075] (162 genes, 222 annotations)
                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                is-aDNA integrity checkpoint +
                                                is-ameiotic cell cycle checkpoint +
                                                is-amitotic cell cycle checkpoint +
                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                regulatesregulation of cell cycle checkpoint +
                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                is-aspindle checkpoint +
                                        is-acell cycle DNA replication +
                                        is-acell cycle DNA replication DNA ligation +
                                        is-acell cycle DNA replication DNA unwinding +
                                        is-acell cycle DNA replication initiation +
                                        is-acell cycle DNA replication maintenance of fidelity +
                                        is-acell cycle DNA replication termination +
                                        is-acell cycle phase transition +
                                        is-acell cycle switching +
                                        is-acentriole elongation +
                                        is-acentriole replication +
                                        is-acentromere separation +
                                        is-acentrosome cycle +
                                        is-acentrosome duplication +
                                        is-acentrosome separation +
                                        is-achromosome attachment to the nuclear envelope +
                                        is-achromosome movement towards spindle pole +
                                        is-achromosome separation +
                                        is-acohesin localization to chromatin +
                                        is-acytokinesis +
                                        is-acytokinetic process +
                                        is-aDNA replication preinitiation complex assembly +
                                        is-aDNA strand elongation involved in cell cycle DNA replication +
                                        is-aestablishment of sister chromatid cohesion +
                                        is-aG0 to G1 transition +
                                        is-aG1 to G0 transition +
                                        is-ainterphase microtubule nucleation by interphase microtubule organizing center
                                        is-amaintenance of protein location in spindle pole body
                                        is-amaintenance of sister chromatid cohesion +
                                        is-ameiotic cell cycle process +
                                        is-amicrotubule anchoring at spindle pole body +
                                        is-amitotic cell cycle process +
                                        is-amyosin filament organization involved in cytokinetic actomyosin contractile ring assembly
                                        negatively-regulatesnegative regulation of cell cycle process +
                                        is-anuclear chromosome segregation +
                                        positively-regulatespositive regulation of cell cycle process +
                                        is-apre-replicative complex assembly involved in cell cycle DNA replication +
                                        is-aprotein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly +
                                        is-are-entry into mitotic cell cycle +
                                        regulatesregulation of cell cycle process +
                                        is-aregulation of syncytial blastoderm mitotic cell cycle +
                                        is-asecondary cell wall biogenesis involved in seed trichome differentiation
                                        is-asignal transduction involved in cell cycle checkpoint +
                                        is-asister chromatid cohesion +
                                        is-aspindle elongation +
                                        is-aspindle localization +
                                        is-aspindle midzone assembly +
                                        is-aspindle organization +
                                        is-aspindle pole body organization +
                                        is-aspindle pole body separation +
                                        is-asynthesis of RNA primer involved in cell cycle DNA replication +
                                        is-atelomere maintenance via semi-conservative replication +


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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory