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Gene Ontology Browser
Term Detail
GO term:cell cycle checkpoint
Synonym: G1/S checkpoint
Synonym: G1/S transition checkpoint
Synonym: G2/M checkpoint
Synonym: G2/M transition checkpoint
GO id:GO:0000075
Alternate id: GO:0031576, GO:0071779
Definition:A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
CommentsThis term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
Number of paths to term: 15

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of cellular process
                                                is-anegative regulation of cell cycle
                                                        is-acell cycle arrest +
                                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                                is-aDNA integrity checkpoint +
                                                                is-ameiotic cell cycle checkpoint +
                                                                is-amitotic cell cycle checkpoint +
                                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                                regulatesregulation of cell cycle checkpoint +
                                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                                is-aspindle checkpoint +
                                                        is-anegative regulation by symbiont of host cell cycle
                                                        is-anegative regulation of cell cycle process +
                                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                        is-anegative regulation of meiotic cell cycle +
                                                        is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-anegative regulation of cellular process
                                                is-anegative regulation of cell cycle
                                                        is-acell cycle arrest +
                                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                                is-aDNA integrity checkpoint +
                                                                is-ameiotic cell cycle checkpoint +
                                                                is-amitotic cell cycle checkpoint +
                                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                                regulatesregulation of cell cycle checkpoint +
                                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                                is-aspindle checkpoint +
                                                        is-anegative regulation by symbiont of host cell cycle
                                                        is-anegative regulation of cell cycle process +
                                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                        is-anegative regulation of meiotic cell cycle +
                                                        is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-aregulation of cell cycle
                                                is-anegative regulation of cell cycle
                                                        is-acell cycle arrest +
                                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                                is-aDNA integrity checkpoint +
                                                                is-ameiotic cell cycle checkpoint +
                                                                is-amitotic cell cycle checkpoint +
                                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                                regulatesregulation of cell cycle checkpoint +
                                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                                is-aspindle checkpoint +
                                                        is-anegative regulation by symbiont of host cell cycle
                                                        is-anegative regulation of cell cycle process +
                                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                        is-anegative regulation of meiotic cell cycle +
                                                        is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-aautophagy +
                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                is-aDNA integrity checkpoint +
                                is-ameiotic cell cycle checkpoint +
                                is-amitotic cell cycle checkpoint +
                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                positively-regulatespositive regulation of cell cycle checkpoint +
                                regulatesregulation of cell cycle checkpoint +
                                part-ofsignal transduction involved in cell cycle checkpoint +
                                is-aspindle checkpoint +
                        is-acell cycle process +
                        is-acell separation after cytokinesis +
                        is-acell wall organization or biogenesis +
                        is-acellular component organization +
                        is-acellular detoxification +
                        is-acellular metabolic process +
                        is-acellular response to stimulus +
                        is-acytolysis +
                        is-aintercellular transport +
                        is-amulti-organism cellular process +
                        negatively-regulatesnegative regulation of cellular process +
                        is-aphenotypic switching +
                        positively-regulatespositive regulation of cellular process +
                        is-aprotein folding +
                        is-aprotein unfolding
                        regulatesregulation of cellular process +
                        is-asignal transduction +
                        is-asingle-organism cellular process +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        negatively-regulatesnegative regulation of cellular process
                                is-anegative regulation of cell cycle
                                        is-acell cycle arrest +
                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                is-aDNA integrity checkpoint +
                                                is-ameiotic cell cycle checkpoint +
                                                is-amitotic cell cycle checkpoint +
                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                regulatesregulation of cell cycle checkpoint +
                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                is-aspindle checkpoint +
                                        is-anegative regulation by symbiont of host cell cycle
                                        is-anegative regulation of cell cycle process +
                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                        is-anegative regulation of meiotic cell cycle +
                                        is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-anegative regulation of cellular process
                                        is-anegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-aregulation of cell cycle
                                        is-anegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        negatively-regulatesnegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        regulatesregulation of cell cycle
                                                is-anegative regulation of cell cycle
                                                        is-acell cycle arrest +
                                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                                is-aDNA integrity checkpoint +
                                                                is-ameiotic cell cycle checkpoint +
                                                                is-amitotic cell cycle checkpoint +
                                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                                regulatesregulation of cell cycle checkpoint +
                                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                                is-aspindle checkpoint +
                                                        is-anegative regulation by symbiont of host cell cycle
                                                        is-anegative regulation of cell cycle process +
                                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                        is-anegative regulation of meiotic cell cycle +
                                                        is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                negatively-regulatesnegative regulation of biological process
                        is-anegative regulation of cellular process
                                is-anegative regulation of cell cycle
                                        is-acell cycle arrest +
                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                is-aDNA integrity checkpoint +
                                                is-ameiotic cell cycle checkpoint +
                                                is-amitotic cell cycle checkpoint +
                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                regulatesregulation of cell cycle checkpoint +
                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                is-aspindle checkpoint +
                                        is-anegative regulation by symbiont of host cell cycle
                                        is-anegative regulation of cell cycle process +
                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                        is-anegative regulation of meiotic cell cycle +
                                        is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-anegative regulation of biological process
                                is-anegative regulation of cellular process
                                        is-anegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-anegative regulation of cellular process
                                        is-anegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-aregulation of cell cycle
                                        is-anegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        negatively-regulatesnegative regulation of cell cycle
                                                is-acell cycle arrest +
                                                is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                        part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                        is-aDNA integrity checkpoint +
                                                        is-ameiotic cell cycle checkpoint +
                                                        is-amitotic cell cycle checkpoint +
                                                        negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                        positively-regulatespositive regulation of cell cycle checkpoint +
                                                        regulatesregulation of cell cycle checkpoint +
                                                        part-ofsignal transduction involved in cell cycle checkpoint +
                                                        is-aspindle checkpoint +
                                                is-anegative regulation by symbiont of host cell cycle
                                                is-anegative regulation of cell cycle process +
                                                is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                is-anegative regulation of meiotic cell cycle +
                                                is-anegative regulation of mitotic cell cycle +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        regulatesregulation of cell cycle
                                                is-anegative regulation of cell cycle
                                                        is-acell cycle arrest +
                                                        is-acell cycle checkpoint [GO:0000075] (174 genes, 250 annotations)
                                                                part-ofdetection of stimulus involved in cell cycle checkpoint +
                                                                is-aDNA integrity checkpoint +
                                                                is-ameiotic cell cycle checkpoint +
                                                                is-amitotic cell cycle checkpoint +
                                                                negatively-regulatesnegative regulation of cell cycle checkpoint +
                                                                positively-regulatespositive regulation of cell cycle checkpoint +
                                                                regulatesregulation of cell cycle checkpoint +
                                                                part-ofsignal transduction involved in cell cycle checkpoint +
                                                                is-aspindle checkpoint +
                                                        is-anegative regulation by symbiont of host cell cycle
                                                        is-anegative regulation of cell cycle process +
                                                        is-anegative regulation of cyclin-dependent protein serine/threonine kinase activity +
                                                        is-anegative regulation of meiotic cell cycle +
                                                        is-anegative regulation of mitotic cell cycle +


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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory