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Cd209btm1.1(cre,HBEGF)Bcgen - Hemolymphoid System
Recombinase Activity Detail
Allele Information
Allele:
Cd209btm1.1(cre,HBEGF)Bcgen
CD209b antigen; targeted mutation 1.1, Biocytogen LLC 		Driver: Cd209b
Type: Targeted (Inserted expressed sequence, Recombinase)
Synonym: Cd209btm1.1(cre,DTR)Bcgen, SIGN-R1-Cre/DTR
Molecular description: A cDNA construct encoding an Frt-flanked neomycin resistance cassette followed by a stop cassette was introduced before a start codon, followed by cDNA encoding Cre recombinase, and the human DTR (HBEGF) was generated. The Cre recombinase and DTR coding sequences were separated by self-cleaving 2A viral sequences to allow stoichiometric translation of both individual proteins. This construct was inserted at the ATG start codon of cd209b, effectively replacing the expression of SIGN-R1. The neomycin resistance gene and stop cassette was removed by crossing to FLPO mice.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Hemolymphoid System Other recombinase alleles with activity in Hemolymphoid System tissues:
Images
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J:288614 Fig. S5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory