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Fgf10tm2.1(cre/ERT2)Sbel - Head
Recombinase Activity Detail
Allele Information
Allele:
Fgf10tm2.1(cre/ERT2)Sbel
fibroblast growth factor 10; targeted mutation 2.1, Saverio Bellusci
Driver: Fgf10
Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: Fgf10Cre-ERT2, Fgf10Ki-v2, Fgf10tm2(eYFP-Cre/ERT2)Sbel
Molecular description: An EGFP gene and inducible cre/ERT2 fusion were inserted into the 3' UTR immediately downstream of the stop codon of the exon 3. The self-cleavage LF2A and T2A sequences will lead to 3 distinct proteins. Flp-mediated recombination removed the selection cassette. The homozygous embryos suffered from lung and limb agenesis and the analysis of Fgf10 expression by qPCR indicated a drastic reduction in Fgf10 expression. It is a loss-of-function allele.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Fgf10tm2.1(cre/ERT2)Sbel activity also observed in:
alimentary system, limbs, respiratory system, sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Images
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J:308431 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory