Ghrh<tm1.1(cre)Mgmj> - Nervous System Recombinase Activity Detail MGI Mouse

Ghrh^{tm1.1(cre)Mgmj} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Ghrh^{tm1.1(cre)Mgmj}
growth hormone releasing hormone; targeted mutation 1.1, Martin G Myers, Jr

Driver: Ghrh
Type: Targeted (Recombinase)

Synonym:

Ghrh^Cre

Molecular description:

A targeting construct was designed to replace the stop codon of the growth hormone releasing hormone (Ghrh) gene with a viral P2A oligopeptide, from porcine teschovirus-1, fused to a Cre recombinase gene. A frt-flanked neomycin resistance (neo) cassette inserted downstream. The construct was electroporated into R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred with B6.129S4-Gt(ROSA)26Sor/J mice to remove the neo cassette.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Ghrh^{tm1.1(cre)Mgmj} activity also observed in:
head

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Images

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J:264547 Fig. 1B

J:264547 Fig. S1

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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